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Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation
Renal inflammation is an initial pathological process during progressive renal injury regardless of the initial cause. Macrophage migration inhibitory factor (MIF) is a truly proinflammatory stress mediator that is highly expressed in a variety of both inflammatory cells and intrinsic kidney cells....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102975/ https://www.ncbi.nlm.nih.gov/pubmed/35563296 http://dx.doi.org/10.3390/ijms23094908 |
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author | Kong, Yao-Zhong Chen, Qiyan Lan, Hui-Yao |
author_facet | Kong, Yao-Zhong Chen, Qiyan Lan, Hui-Yao |
author_sort | Kong, Yao-Zhong |
collection | PubMed |
description | Renal inflammation is an initial pathological process during progressive renal injury regardless of the initial cause. Macrophage migration inhibitory factor (MIF) is a truly proinflammatory stress mediator that is highly expressed in a variety of both inflammatory cells and intrinsic kidney cells. MIF is released from the diseased kidney immediately upon stimulation to trigger renal inflammation by activating macrophages and T cells, and promoting the production of proinflammatory cytokines, chemokines, and stress molecules via signaling pathways involving the CD74/CD44 and chemokine receptors CXCR2, CXCR4, and CXCR7 signaling. In addition, MIF can function as a stress molecule to counter-regulate the immunosuppressive effect of glucocorticoid in renal inflammation. Given the critical position of MIF in the upstream inflammatory cascade, this review focuses on the regulatory role and molecular mechanisms of MIF in kidney diseases. The therapeutic potential of targeting MIF signaling to treat kidney diseases is also discussed. |
format | Online Article Text |
id | pubmed-9102975 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91029752022-05-14 Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation Kong, Yao-Zhong Chen, Qiyan Lan, Hui-Yao Int J Mol Sci Review Renal inflammation is an initial pathological process during progressive renal injury regardless of the initial cause. Macrophage migration inhibitory factor (MIF) is a truly proinflammatory stress mediator that is highly expressed in a variety of both inflammatory cells and intrinsic kidney cells. MIF is released from the diseased kidney immediately upon stimulation to trigger renal inflammation by activating macrophages and T cells, and promoting the production of proinflammatory cytokines, chemokines, and stress molecules via signaling pathways involving the CD74/CD44 and chemokine receptors CXCR2, CXCR4, and CXCR7 signaling. In addition, MIF can function as a stress molecule to counter-regulate the immunosuppressive effect of glucocorticoid in renal inflammation. Given the critical position of MIF in the upstream inflammatory cascade, this review focuses on the regulatory role and molecular mechanisms of MIF in kidney diseases. The therapeutic potential of targeting MIF signaling to treat kidney diseases is also discussed. MDPI 2022-04-28 /pmc/articles/PMC9102975/ /pubmed/35563296 http://dx.doi.org/10.3390/ijms23094908 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kong, Yao-Zhong Chen, Qiyan Lan, Hui-Yao Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation |
title | Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation |
title_full | Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation |
title_fullStr | Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation |
title_full_unstemmed | Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation |
title_short | Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation |
title_sort | macrophage migration inhibitory factor (mif) as a stress molecule in renal inflammation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102975/ https://www.ncbi.nlm.nih.gov/pubmed/35563296 http://dx.doi.org/10.3390/ijms23094908 |
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