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Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation

Renal inflammation is an initial pathological process during progressive renal injury regardless of the initial cause. Macrophage migration inhibitory factor (MIF) is a truly proinflammatory stress mediator that is highly expressed in a variety of both inflammatory cells and intrinsic kidney cells....

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Detalles Bibliográficos
Autores principales: Kong, Yao-Zhong, Chen, Qiyan, Lan, Hui-Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102975/
https://www.ncbi.nlm.nih.gov/pubmed/35563296
http://dx.doi.org/10.3390/ijms23094908
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author Kong, Yao-Zhong
Chen, Qiyan
Lan, Hui-Yao
author_facet Kong, Yao-Zhong
Chen, Qiyan
Lan, Hui-Yao
author_sort Kong, Yao-Zhong
collection PubMed
description Renal inflammation is an initial pathological process during progressive renal injury regardless of the initial cause. Macrophage migration inhibitory factor (MIF) is a truly proinflammatory stress mediator that is highly expressed in a variety of both inflammatory cells and intrinsic kidney cells. MIF is released from the diseased kidney immediately upon stimulation to trigger renal inflammation by activating macrophages and T cells, and promoting the production of proinflammatory cytokines, chemokines, and stress molecules via signaling pathways involving the CD74/CD44 and chemokine receptors CXCR2, CXCR4, and CXCR7 signaling. In addition, MIF can function as a stress molecule to counter-regulate the immunosuppressive effect of glucocorticoid in renal inflammation. Given the critical position of MIF in the upstream inflammatory cascade, this review focuses on the regulatory role and molecular mechanisms of MIF in kidney diseases. The therapeutic potential of targeting MIF signaling to treat kidney diseases is also discussed.
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spelling pubmed-91029752022-05-14 Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation Kong, Yao-Zhong Chen, Qiyan Lan, Hui-Yao Int J Mol Sci Review Renal inflammation is an initial pathological process during progressive renal injury regardless of the initial cause. Macrophage migration inhibitory factor (MIF) is a truly proinflammatory stress mediator that is highly expressed in a variety of both inflammatory cells and intrinsic kidney cells. MIF is released from the diseased kidney immediately upon stimulation to trigger renal inflammation by activating macrophages and T cells, and promoting the production of proinflammatory cytokines, chemokines, and stress molecules via signaling pathways involving the CD74/CD44 and chemokine receptors CXCR2, CXCR4, and CXCR7 signaling. In addition, MIF can function as a stress molecule to counter-regulate the immunosuppressive effect of glucocorticoid in renal inflammation. Given the critical position of MIF in the upstream inflammatory cascade, this review focuses on the regulatory role and molecular mechanisms of MIF in kidney diseases. The therapeutic potential of targeting MIF signaling to treat kidney diseases is also discussed. MDPI 2022-04-28 /pmc/articles/PMC9102975/ /pubmed/35563296 http://dx.doi.org/10.3390/ijms23094908 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kong, Yao-Zhong
Chen, Qiyan
Lan, Hui-Yao
Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation
title Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation
title_full Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation
title_fullStr Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation
title_full_unstemmed Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation
title_short Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation
title_sort macrophage migration inhibitory factor (mif) as a stress molecule in renal inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102975/
https://www.ncbi.nlm.nih.gov/pubmed/35563296
http://dx.doi.org/10.3390/ijms23094908
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