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Cytokines: Can Cancer Get the Message?

SIMPLE SUMMARY: Cytokines are important molecular players in cancer development, progression, and potential targets for treatment. Despite being small and overlooked, research has revealed that cytokines influence cancer biology in multiple ways. Cytokines are often found to contribute to immune fun...

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Detalles Bibliográficos
Autores principales: Morris, Rachel M., Mortimer, Toni O., O’Neill, Kim L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103018/
https://www.ncbi.nlm.nih.gov/pubmed/35565306
http://dx.doi.org/10.3390/cancers14092178
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author Morris, Rachel M.
Mortimer, Toni O.
O’Neill, Kim L.
author_facet Morris, Rachel M.
Mortimer, Toni O.
O’Neill, Kim L.
author_sort Morris, Rachel M.
collection PubMed
description SIMPLE SUMMARY: Cytokines are important molecular players in cancer development, progression, and potential targets for treatment. Despite being small and overlooked, research has revealed that cytokines influence cancer biology in multiple ways. Cytokines are often found to contribute to immune function, cell damage, inflammation, angiogenesis, metastasis, and several other cellular processes important to tumor survival. Cytokines have also proven to have powerful effects on complex tumor microenvironment molecular biology and microbiology. Due to their heavy involvement in critical cancer-related processes, cytokines have also become attractive therapeutic targets for cancer treatment. In this review, we describe the relationship between several cytokines and crucial cancer-promoting processes and their therapeutic potential. ABSTRACT: Cytokines are small molecular messengers that have profound effects on cancer development. Increasing evidence shows that cytokines are heavily involved in regulating both pro- and antitumor activities, such as immune activation and suppression, inflammation, cell damage, angiogenesis, cancer stem-cell-like cell maintenance, invasion, and metastasis. Cytokines are often required to drive these cancer-related processes and, therefore, represent an important research area for understanding cancer development and the potential identification of novel therapeutic targets. Interestingly, some cytokines are reported to be related to both pro- and anti-tumorigenicity, indicating that cytokines may play several complex roles relating to cancer pathogenesis. In this review, we discuss some major cancer-related processes and their relationship with several cytokines.
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spelling pubmed-91030182022-05-14 Cytokines: Can Cancer Get the Message? Morris, Rachel M. Mortimer, Toni O. O’Neill, Kim L. Cancers (Basel) Review SIMPLE SUMMARY: Cytokines are important molecular players in cancer development, progression, and potential targets for treatment. Despite being small and overlooked, research has revealed that cytokines influence cancer biology in multiple ways. Cytokines are often found to contribute to immune function, cell damage, inflammation, angiogenesis, metastasis, and several other cellular processes important to tumor survival. Cytokines have also proven to have powerful effects on complex tumor microenvironment molecular biology and microbiology. Due to their heavy involvement in critical cancer-related processes, cytokines have also become attractive therapeutic targets for cancer treatment. In this review, we describe the relationship between several cytokines and crucial cancer-promoting processes and their therapeutic potential. ABSTRACT: Cytokines are small molecular messengers that have profound effects on cancer development. Increasing evidence shows that cytokines are heavily involved in regulating both pro- and antitumor activities, such as immune activation and suppression, inflammation, cell damage, angiogenesis, cancer stem-cell-like cell maintenance, invasion, and metastasis. Cytokines are often required to drive these cancer-related processes and, therefore, represent an important research area for understanding cancer development and the potential identification of novel therapeutic targets. Interestingly, some cytokines are reported to be related to both pro- and anti-tumorigenicity, indicating that cytokines may play several complex roles relating to cancer pathogenesis. In this review, we discuss some major cancer-related processes and their relationship with several cytokines. MDPI 2022-04-27 /pmc/articles/PMC9103018/ /pubmed/35565306 http://dx.doi.org/10.3390/cancers14092178 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Morris, Rachel M.
Mortimer, Toni O.
O’Neill, Kim L.
Cytokines: Can Cancer Get the Message?
title Cytokines: Can Cancer Get the Message?
title_full Cytokines: Can Cancer Get the Message?
title_fullStr Cytokines: Can Cancer Get the Message?
title_full_unstemmed Cytokines: Can Cancer Get the Message?
title_short Cytokines: Can Cancer Get the Message?
title_sort cytokines: can cancer get the message?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103018/
https://www.ncbi.nlm.nih.gov/pubmed/35565306
http://dx.doi.org/10.3390/cancers14092178
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