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At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success

We investigated the role of rhIL-35, at low concentrations compatible with those produced by human trophoblast cells (less than 1 ng/mL), on human T helper (Th) cell functions and the presence of decidual IL-35-producing Th cells in human pregnancy. We found that human trophoblast cells produced IL-...

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Detalles Bibliográficos
Autores principales: Lombardelli, Letizia, Logiodice, Federica, Kullolli, Ornela, Haller, Herman, Agostinis, Chiara, Bulla, Roberta, Rukavina, Daniel, Piccinni, Marie-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103079/
https://www.ncbi.nlm.nih.gov/pubmed/35563316
http://dx.doi.org/10.3390/ijms23094926