Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of fragile X syndrome

BACKGROUND: Fragile X syndrome (FXS), the most prevalent inherited intellectual disability and one of the most common monogenic forms of autism, is caused by a loss of fragile X messenger ribonucleoprotein 1 (FMR1). We have previously shown that FMR1 represses the levels and activities of ubiquitin...

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Detalles Bibliográficos
Autores principales: Javadi, Sahar, Li, Yue, Sheng, Jie, Zhao, Lucy, Fu, Yao, Wang, Daifeng, Zhao, Xinyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103116/
https://www.ncbi.nlm.nih.gov/pubmed/35549943
http://dx.doi.org/10.1186/s12916-022-02370-9

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