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Arabinoxylan-Carboxymethylcellulose Composite Films for Antibiotic Delivery to Infected Wounds

Modern dressings should provide for local delivery of antibiotics and protect the wound from bacterial infection, dehydration and environmental factors to achieve optimal healing. The local delivery of antibiotics can reduce adverse effects and resistance challenges. In this study, we fabricated fil...

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Autores principales: Alruwaili, Nabil K., Ahmad, Naveed, Alzarea, Abdulaziz I., Alomar, Fadhel A., Alquraini, Ali, Akhtar, Sultan, Shahari, Muhammad Syafiq Bin, Zafar, Ameeduzzafar, Elmowafy, Mohammed, Elkomy, Mohammed H., Dolzhenko, Anton V., Iqbal, Mohammad Saeed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103158/
https://www.ncbi.nlm.nih.gov/pubmed/35566937
http://dx.doi.org/10.3390/polym14091769
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author Alruwaili, Nabil K.
Ahmad, Naveed
Alzarea, Abdulaziz I.
Alomar, Fadhel A.
Alquraini, Ali
Akhtar, Sultan
Shahari, Muhammad Syafiq Bin
Zafar, Ameeduzzafar
Elmowafy, Mohammed
Elkomy, Mohammed H.
Dolzhenko, Anton V.
Iqbal, Mohammad Saeed
author_facet Alruwaili, Nabil K.
Ahmad, Naveed
Alzarea, Abdulaziz I.
Alomar, Fadhel A.
Alquraini, Ali
Akhtar, Sultan
Shahari, Muhammad Syafiq Bin
Zafar, Ameeduzzafar
Elmowafy, Mohammed
Elkomy, Mohammed H.
Dolzhenko, Anton V.
Iqbal, Mohammad Saeed
author_sort Alruwaili, Nabil K.
collection PubMed
description Modern dressings should provide for local delivery of antibiotics and protect the wound from bacterial infection, dehydration and environmental factors to achieve optimal healing. The local delivery of antibiotics can reduce adverse effects and resistance challenges. In this study, we fabricated film dressings composed of arabinoxylan (AX) from Plantago ovata seed husks and carboxymethylcellulose (CMC) by a solvent cast method for the delivery of the antibiotic amikacin (AMK). To determine the suitability of the prepared AX-CMC composite films as wound dressings and drug delivery materials, their physical, chemical, mechanical, morphological, thermal, pharmaceutical, antimicrobial, cytocompatible, and drug delivery properties were investigated. The results demonstrated that the dressings were suitable for delivering the drug at the wound site in a sustained manner and keeping the environment moist for rapid healing. The AMK-loaded AX-CMC films exhibited controlled release of AMK, excellent antibacterial activity, and cytocompatibility. Thus, the AX-CMC composite films appear to be promising bioactive dressing materials for the prevention of wound infections.
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spelling pubmed-91031582022-05-14 Arabinoxylan-Carboxymethylcellulose Composite Films for Antibiotic Delivery to Infected Wounds Alruwaili, Nabil K. Ahmad, Naveed Alzarea, Abdulaziz I. Alomar, Fadhel A. Alquraini, Ali Akhtar, Sultan Shahari, Muhammad Syafiq Bin Zafar, Ameeduzzafar Elmowafy, Mohammed Elkomy, Mohammed H. Dolzhenko, Anton V. Iqbal, Mohammad Saeed Polymers (Basel) Article Modern dressings should provide for local delivery of antibiotics and protect the wound from bacterial infection, dehydration and environmental factors to achieve optimal healing. The local delivery of antibiotics can reduce adverse effects and resistance challenges. In this study, we fabricated film dressings composed of arabinoxylan (AX) from Plantago ovata seed husks and carboxymethylcellulose (CMC) by a solvent cast method for the delivery of the antibiotic amikacin (AMK). To determine the suitability of the prepared AX-CMC composite films as wound dressings and drug delivery materials, their physical, chemical, mechanical, morphological, thermal, pharmaceutical, antimicrobial, cytocompatible, and drug delivery properties were investigated. The results demonstrated that the dressings were suitable for delivering the drug at the wound site in a sustained manner and keeping the environment moist for rapid healing. The AMK-loaded AX-CMC films exhibited controlled release of AMK, excellent antibacterial activity, and cytocompatibility. Thus, the AX-CMC composite films appear to be promising bioactive dressing materials for the prevention of wound infections. MDPI 2022-04-27 /pmc/articles/PMC9103158/ /pubmed/35566937 http://dx.doi.org/10.3390/polym14091769 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alruwaili, Nabil K.
Ahmad, Naveed
Alzarea, Abdulaziz I.
Alomar, Fadhel A.
Alquraini, Ali
Akhtar, Sultan
Shahari, Muhammad Syafiq Bin
Zafar, Ameeduzzafar
Elmowafy, Mohammed
Elkomy, Mohammed H.
Dolzhenko, Anton V.
Iqbal, Mohammad Saeed
Arabinoxylan-Carboxymethylcellulose Composite Films for Antibiotic Delivery to Infected Wounds
title Arabinoxylan-Carboxymethylcellulose Composite Films for Antibiotic Delivery to Infected Wounds
title_full Arabinoxylan-Carboxymethylcellulose Composite Films for Antibiotic Delivery to Infected Wounds
title_fullStr Arabinoxylan-Carboxymethylcellulose Composite Films for Antibiotic Delivery to Infected Wounds
title_full_unstemmed Arabinoxylan-Carboxymethylcellulose Composite Films for Antibiotic Delivery to Infected Wounds
title_short Arabinoxylan-Carboxymethylcellulose Composite Films for Antibiotic Delivery to Infected Wounds
title_sort arabinoxylan-carboxymethylcellulose composite films for antibiotic delivery to infected wounds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103158/
https://www.ncbi.nlm.nih.gov/pubmed/35566937
http://dx.doi.org/10.3390/polym14091769
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