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Clinical characteristics of COVID-19 in young patients differ from middle-aged and elderly patients

INTRODUCTION: Coronavirus disease-2019 (COVID-19) has spread worldwide. The study aimed to understand the clinical characteristics of young COVID-19 patients. MATERIAL AND METHODS: Ninety patients with severe COVID-19 infection in western Chongqing were collected from 21 January to 14 March 2020. Th...

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Autores principales: Wan, Keqiang, Su, Chang, Kong, Lingxi, Liao, Juan, Tian, Wenguang, Luo, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103402/
https://www.ncbi.nlm.nih.gov/pubmed/35591815
http://dx.doi.org/10.5114/aoms/133090
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author Wan, Keqiang
Su, Chang
Kong, Lingxi
Liao, Juan
Tian, Wenguang
Luo, Hua
author_facet Wan, Keqiang
Su, Chang
Kong, Lingxi
Liao, Juan
Tian, Wenguang
Luo, Hua
author_sort Wan, Keqiang
collection PubMed
description INTRODUCTION: Coronavirus disease-2019 (COVID-19) has spread worldwide. The study aimed to understand the clinical characteristics of young COVID-19 patients. MATERIAL AND METHODS: Ninety patients with severe COVID-19 infection in western Chongqing were collected from 21 January to 14 March 2020. They were divided into 4 groups based on age: youth (< 39 years), middle-aged (39–48 years), middle-elderly aged (49–60 years), and elderly (> 60 years). The clinical symptoms, laboratory findings, imaging findings, and treatment effects were compared among the groups. RESULTS: There were 22, 27, 19, and 22 cases in the youth, middle-aged, middle-elderly, and elderly groups, respectively. There were no significant differences with respect to gender or smoking status among the four groups. The clinical indicators of severe disease in the youth group were significantly different from the other three groups, and included the lymphocyte count (p < 0.001), C-reactive protein level (p = 0.03), interleukin-6 level (p = 0.01), chest computed tomography (CT) findings (p < 0.001), number of mild cases (p = 0.02), education level (p < 0.001), and CD4 + T lymphocyte level (p = 0.02) at the time of admission, and the pneumonia severity index (PSI) at the time of discharge (p < 0.001). The complications (p < 0.001) among the youth group were also significantly different from the other groups. CONCLUSIONS: Young patients have milder clinical manifestations, which may be related to higher education level, higher awareness and higher acceptance of the prevention and control of the COVID-19 epidemic, as well as their good immune function.
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spelling pubmed-91034022022-05-18 Clinical characteristics of COVID-19 in young patients differ from middle-aged and elderly patients Wan, Keqiang Su, Chang Kong, Lingxi Liao, Juan Tian, Wenguang Luo, Hua Arch Med Sci Clinical Research INTRODUCTION: Coronavirus disease-2019 (COVID-19) has spread worldwide. The study aimed to understand the clinical characteristics of young COVID-19 patients. MATERIAL AND METHODS: Ninety patients with severe COVID-19 infection in western Chongqing were collected from 21 January to 14 March 2020. They were divided into 4 groups based on age: youth (< 39 years), middle-aged (39–48 years), middle-elderly aged (49–60 years), and elderly (> 60 years). The clinical symptoms, laboratory findings, imaging findings, and treatment effects were compared among the groups. RESULTS: There were 22, 27, 19, and 22 cases in the youth, middle-aged, middle-elderly, and elderly groups, respectively. There were no significant differences with respect to gender or smoking status among the four groups. The clinical indicators of severe disease in the youth group were significantly different from the other three groups, and included the lymphocyte count (p < 0.001), C-reactive protein level (p = 0.03), interleukin-6 level (p = 0.01), chest computed tomography (CT) findings (p < 0.001), number of mild cases (p = 0.02), education level (p < 0.001), and CD4 + T lymphocyte level (p = 0.02) at the time of admission, and the pneumonia severity index (PSI) at the time of discharge (p < 0.001). The complications (p < 0.001) among the youth group were also significantly different from the other groups. CONCLUSIONS: Young patients have milder clinical manifestations, which may be related to higher education level, higher awareness and higher acceptance of the prevention and control of the COVID-19 epidemic, as well as their good immune function. Termedia Publishing House 2021-03-21 /pmc/articles/PMC9103402/ /pubmed/35591815 http://dx.doi.org/10.5114/aoms/133090 Text en Copyright: © 2022 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Wan, Keqiang
Su, Chang
Kong, Lingxi
Liao, Juan
Tian, Wenguang
Luo, Hua
Clinical characteristics of COVID-19 in young patients differ from middle-aged and elderly patients
title Clinical characteristics of COVID-19 in young patients differ from middle-aged and elderly patients
title_full Clinical characteristics of COVID-19 in young patients differ from middle-aged and elderly patients
title_fullStr Clinical characteristics of COVID-19 in young patients differ from middle-aged and elderly patients
title_full_unstemmed Clinical characteristics of COVID-19 in young patients differ from middle-aged and elderly patients
title_short Clinical characteristics of COVID-19 in young patients differ from middle-aged and elderly patients
title_sort clinical characteristics of covid-19 in young patients differ from middle-aged and elderly patients
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103402/
https://www.ncbi.nlm.nih.gov/pubmed/35591815
http://dx.doi.org/10.5114/aoms/133090
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