Cargando…

Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation

The role of IL-22 in adult patients undergoing allogeneic stem cell transplantation (SCT) is of major interest since animal studies showed a protective and regenerative effect of IL-22 in graft versus host disease (GvHD). However, no clinical data exist on the tissue expression. Here we demonstrate...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghimire, Sakhila, Ederer, Katharina U., Meedt, Elisabeth, Weber, Daniela, Matos, Carina, Hiergeist, Andreas, Zeman, Florian, Wolff, Daniel, Edinger, Matthias, Poeck, Hendrik, Herr, Wolfgang, Gessner, André, Holler, Ernst, Bülow, Sigrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103485/
https://www.ncbi.nlm.nih.gov/pubmed/35572572
http://dx.doi.org/10.3389/fimmu.2022.857400
_version_ 1784707567714304000
author Ghimire, Sakhila
Ederer, Katharina U.
Meedt, Elisabeth
Weber, Daniela
Matos, Carina
Hiergeist, Andreas
Zeman, Florian
Wolff, Daniel
Edinger, Matthias
Poeck, Hendrik
Herr, Wolfgang
Gessner, André
Holler, Ernst
Bülow, Sigrid
author_facet Ghimire, Sakhila
Ederer, Katharina U.
Meedt, Elisabeth
Weber, Daniela
Matos, Carina
Hiergeist, Andreas
Zeman, Florian
Wolff, Daniel
Edinger, Matthias
Poeck, Hendrik
Herr, Wolfgang
Gessner, André
Holler, Ernst
Bülow, Sigrid
author_sort Ghimire, Sakhila
collection PubMed
description The role of IL-22 in adult patients undergoing allogeneic stem cell transplantation (SCT) is of major interest since animal studies showed a protective and regenerative effect of IL-22 in graft versus host disease (GvHD). However, no clinical data exist on the tissue expression. Here we demonstrate that patients not suffering from transplant-related mortality (TRM) show significantly upregulated IL22 expression during histological and clinical GI-GvHD (p = 0.048 and p = 0.022, respectively). In contrast, in GvHD patients suffering from TRM, IL22 was significantly lower (p = 0.007). Accordingly, lower IL22 was associated with a higher probability of TRM in survival analysis (p = 0.005). In a multivariable competing risk Cox regression analysis, low IL22 was identified as an independent risk factor for TRM (p = 0.007, hazard ratio 2.72, 95% CI 1.32 to 5.61). The expression of IL22 seemed to be microbiota dependent as broad-spectrum antibiotics significantly diminished IL22 expression (p = 0.019). Furthermore, IL22 expression significantly correlated with G-protein coupled receptor (GPR)43 (r = 0.263, p = 0.015) and GPR41 expression (r = 0.284, p = 0.009). In conclusion, our findings reveal an essential role of IL22 for the prognosis of patients undergoing allogeneic SCT.
format Online
Article
Text
id pubmed-9103485
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91034852022-05-14 Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation Ghimire, Sakhila Ederer, Katharina U. Meedt, Elisabeth Weber, Daniela Matos, Carina Hiergeist, Andreas Zeman, Florian Wolff, Daniel Edinger, Matthias Poeck, Hendrik Herr, Wolfgang Gessner, André Holler, Ernst Bülow, Sigrid Front Immunol Immunology The role of IL-22 in adult patients undergoing allogeneic stem cell transplantation (SCT) is of major interest since animal studies showed a protective and regenerative effect of IL-22 in graft versus host disease (GvHD). However, no clinical data exist on the tissue expression. Here we demonstrate that patients not suffering from transplant-related mortality (TRM) show significantly upregulated IL22 expression during histological and clinical GI-GvHD (p = 0.048 and p = 0.022, respectively). In contrast, in GvHD patients suffering from TRM, IL22 was significantly lower (p = 0.007). Accordingly, lower IL22 was associated with a higher probability of TRM in survival analysis (p = 0.005). In a multivariable competing risk Cox regression analysis, low IL22 was identified as an independent risk factor for TRM (p = 0.007, hazard ratio 2.72, 95% CI 1.32 to 5.61). The expression of IL22 seemed to be microbiota dependent as broad-spectrum antibiotics significantly diminished IL22 expression (p = 0.019). Furthermore, IL22 expression significantly correlated with G-protein coupled receptor (GPR)43 (r = 0.263, p = 0.015) and GPR41 expression (r = 0.284, p = 0.009). In conclusion, our findings reveal an essential role of IL22 for the prognosis of patients undergoing allogeneic SCT. Frontiers Media S.A. 2022-04-29 /pmc/articles/PMC9103485/ /pubmed/35572572 http://dx.doi.org/10.3389/fimmu.2022.857400 Text en Copyright © 2022 Ghimire, Ederer, Meedt, Weber, Matos, Hiergeist, Zeman, Wolff, Edinger, Poeck, Herr, Gessner, Holler and Bülow https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ghimire, Sakhila
Ederer, Katharina U.
Meedt, Elisabeth
Weber, Daniela
Matos, Carina
Hiergeist, Andreas
Zeman, Florian
Wolff, Daniel
Edinger, Matthias
Poeck, Hendrik
Herr, Wolfgang
Gessner, André
Holler, Ernst
Bülow, Sigrid
Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation
title Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation
title_full Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation
title_fullStr Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation
title_full_unstemmed Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation
title_short Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation
title_sort low intestinal il22 associates with increased transplant-related mortality after allogeneic stem cell transplantation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103485/
https://www.ncbi.nlm.nih.gov/pubmed/35572572
http://dx.doi.org/10.3389/fimmu.2022.857400
work_keys_str_mv AT ghimiresakhila lowintestinalil22associateswithincreasedtransplantrelatedmortalityafterallogeneicstemcelltransplantation
AT edererkatharinau lowintestinalil22associateswithincreasedtransplantrelatedmortalityafterallogeneicstemcelltransplantation
AT meedtelisabeth lowintestinalil22associateswithincreasedtransplantrelatedmortalityafterallogeneicstemcelltransplantation
AT weberdaniela lowintestinalil22associateswithincreasedtransplantrelatedmortalityafterallogeneicstemcelltransplantation
AT matoscarina lowintestinalil22associateswithincreasedtransplantrelatedmortalityafterallogeneicstemcelltransplantation
AT hiergeistandreas lowintestinalil22associateswithincreasedtransplantrelatedmortalityafterallogeneicstemcelltransplantation
AT zemanflorian lowintestinalil22associateswithincreasedtransplantrelatedmortalityafterallogeneicstemcelltransplantation
AT wolffdaniel lowintestinalil22associateswithincreasedtransplantrelatedmortalityafterallogeneicstemcelltransplantation
AT edingermatthias lowintestinalil22associateswithincreasedtransplantrelatedmortalityafterallogeneicstemcelltransplantation
AT poeckhendrik lowintestinalil22associateswithincreasedtransplantrelatedmortalityafterallogeneicstemcelltransplantation
AT herrwolfgang lowintestinalil22associateswithincreasedtransplantrelatedmortalityafterallogeneicstemcelltransplantation
AT gessnerandre lowintestinalil22associateswithincreasedtransplantrelatedmortalityafterallogeneicstemcelltransplantation
AT hollerernst lowintestinalil22associateswithincreasedtransplantrelatedmortalityafterallogeneicstemcelltransplantation
AT bulowsigrid lowintestinalil22associateswithincreasedtransplantrelatedmortalityafterallogeneicstemcelltransplantation