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Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation
The role of IL-22 in adult patients undergoing allogeneic stem cell transplantation (SCT) is of major interest since animal studies showed a protective and regenerative effect of IL-22 in graft versus host disease (GvHD). However, no clinical data exist on the tissue expression. Here we demonstrate...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103485/ https://www.ncbi.nlm.nih.gov/pubmed/35572572 http://dx.doi.org/10.3389/fimmu.2022.857400 |
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author | Ghimire, Sakhila Ederer, Katharina U. Meedt, Elisabeth Weber, Daniela Matos, Carina Hiergeist, Andreas Zeman, Florian Wolff, Daniel Edinger, Matthias Poeck, Hendrik Herr, Wolfgang Gessner, André Holler, Ernst Bülow, Sigrid |
author_facet | Ghimire, Sakhila Ederer, Katharina U. Meedt, Elisabeth Weber, Daniela Matos, Carina Hiergeist, Andreas Zeman, Florian Wolff, Daniel Edinger, Matthias Poeck, Hendrik Herr, Wolfgang Gessner, André Holler, Ernst Bülow, Sigrid |
author_sort | Ghimire, Sakhila |
collection | PubMed |
description | The role of IL-22 in adult patients undergoing allogeneic stem cell transplantation (SCT) is of major interest since animal studies showed a protective and regenerative effect of IL-22 in graft versus host disease (GvHD). However, no clinical data exist on the tissue expression. Here we demonstrate that patients not suffering from transplant-related mortality (TRM) show significantly upregulated IL22 expression during histological and clinical GI-GvHD (p = 0.048 and p = 0.022, respectively). In contrast, in GvHD patients suffering from TRM, IL22 was significantly lower (p = 0.007). Accordingly, lower IL22 was associated with a higher probability of TRM in survival analysis (p = 0.005). In a multivariable competing risk Cox regression analysis, low IL22 was identified as an independent risk factor for TRM (p = 0.007, hazard ratio 2.72, 95% CI 1.32 to 5.61). The expression of IL22 seemed to be microbiota dependent as broad-spectrum antibiotics significantly diminished IL22 expression (p = 0.019). Furthermore, IL22 expression significantly correlated with G-protein coupled receptor (GPR)43 (r = 0.263, p = 0.015) and GPR41 expression (r = 0.284, p = 0.009). In conclusion, our findings reveal an essential role of IL22 for the prognosis of patients undergoing allogeneic SCT. |
format | Online Article Text |
id | pubmed-9103485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91034852022-05-14 Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation Ghimire, Sakhila Ederer, Katharina U. Meedt, Elisabeth Weber, Daniela Matos, Carina Hiergeist, Andreas Zeman, Florian Wolff, Daniel Edinger, Matthias Poeck, Hendrik Herr, Wolfgang Gessner, André Holler, Ernst Bülow, Sigrid Front Immunol Immunology The role of IL-22 in adult patients undergoing allogeneic stem cell transplantation (SCT) is of major interest since animal studies showed a protective and regenerative effect of IL-22 in graft versus host disease (GvHD). However, no clinical data exist on the tissue expression. Here we demonstrate that patients not suffering from transplant-related mortality (TRM) show significantly upregulated IL22 expression during histological and clinical GI-GvHD (p = 0.048 and p = 0.022, respectively). In contrast, in GvHD patients suffering from TRM, IL22 was significantly lower (p = 0.007). Accordingly, lower IL22 was associated with a higher probability of TRM in survival analysis (p = 0.005). In a multivariable competing risk Cox regression analysis, low IL22 was identified as an independent risk factor for TRM (p = 0.007, hazard ratio 2.72, 95% CI 1.32 to 5.61). The expression of IL22 seemed to be microbiota dependent as broad-spectrum antibiotics significantly diminished IL22 expression (p = 0.019). Furthermore, IL22 expression significantly correlated with G-protein coupled receptor (GPR)43 (r = 0.263, p = 0.015) and GPR41 expression (r = 0.284, p = 0.009). In conclusion, our findings reveal an essential role of IL22 for the prognosis of patients undergoing allogeneic SCT. Frontiers Media S.A. 2022-04-29 /pmc/articles/PMC9103485/ /pubmed/35572572 http://dx.doi.org/10.3389/fimmu.2022.857400 Text en Copyright © 2022 Ghimire, Ederer, Meedt, Weber, Matos, Hiergeist, Zeman, Wolff, Edinger, Poeck, Herr, Gessner, Holler and Bülow https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Ghimire, Sakhila Ederer, Katharina U. Meedt, Elisabeth Weber, Daniela Matos, Carina Hiergeist, Andreas Zeman, Florian Wolff, Daniel Edinger, Matthias Poeck, Hendrik Herr, Wolfgang Gessner, André Holler, Ernst Bülow, Sigrid Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation |
title | Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation |
title_full | Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation |
title_fullStr | Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation |
title_full_unstemmed | Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation |
title_short | Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation |
title_sort | low intestinal il22 associates with increased transplant-related mortality after allogeneic stem cell transplantation |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103485/ https://www.ncbi.nlm.nih.gov/pubmed/35572572 http://dx.doi.org/10.3389/fimmu.2022.857400 |
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