Cargando…
Are Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Useful as Markers in Diagnostic Management of Children with Newly Diagnosed Ulcerative Colitis?
Matrix Metaloproteinase-9 (MMP-9) and Tissue Inhibitor of Metaloproteinase-1 (TIMP-1), enzymes involved in tissue remodelling, have been previously reported to be overexpressed in the colonic mucosa of patients with Ulcerative colitis (UC). The aim of this study was to determine the relation of MMP-...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103541/ https://www.ncbi.nlm.nih.gov/pubmed/35566780 http://dx.doi.org/10.3390/jcm11092655 |
_version_ | 1784707580565651456 |
---|---|
author | Czajkowska, Aleksandra Guzinska-Ustymowicz, Katarzyna Pryczynicz, Anna Lebensztejn, Dariusz Daniluk, Urszula |
author_facet | Czajkowska, Aleksandra Guzinska-Ustymowicz, Katarzyna Pryczynicz, Anna Lebensztejn, Dariusz Daniluk, Urszula |
author_sort | Czajkowska, Aleksandra |
collection | PubMed |
description | Matrix Metaloproteinase-9 (MMP-9) and Tissue Inhibitor of Metaloproteinase-1 (TIMP-1), enzymes involved in tissue remodelling, have been previously reported to be overexpressed in the colonic mucosa of patients with Ulcerative colitis (UC). The aim of this study was to determine the relation of MMP-9 and TIMP-1 with UC phenotypes, the disease activity index and routinely tested inflammatory markers in newly diagnosed paediatric patients. The study group comprised 35 children diagnosed with UC and 20 control groups. Serum and faecal concentrations of MMP-9 and TIMP-1 were estimated using enzyme-like immunosorbent assay kits and correlated to the disease activity index (Paediatric Ulcerative Colitis Activity Index, PUCAI), UC phenotype (Paris Classification), inflammatory markers and endoscopic score (Mayo score). Children with UC presented with significantly higher serum and faecal concentrations of studied markers compared to the control group. Both serums, MMP-9 and TIMP-1, were higher in children with more extended and severe lesions in the colon. Furthermore, serum MMP-9 correlated with the Mayo score, Paris classification and C-reactive protein (CRP) levels. Serum TIMP-1 showed correlation with PUCAI, Paris Classification, CRP levels and the erythrocyte sedimentation rate. Serum and faecal levels of MMP-9 and TIMP-1 are useful in discriminating UC patients and non-invasive assessments of disease phenotypes. It seemed that simultaneous measurement of these proteins in combination with other common markers of inflammation could be applied in clinical practice. |
format | Online Article Text |
id | pubmed-9103541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91035412022-05-14 Are Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Useful as Markers in Diagnostic Management of Children with Newly Diagnosed Ulcerative Colitis? Czajkowska, Aleksandra Guzinska-Ustymowicz, Katarzyna Pryczynicz, Anna Lebensztejn, Dariusz Daniluk, Urszula J Clin Med Article Matrix Metaloproteinase-9 (MMP-9) and Tissue Inhibitor of Metaloproteinase-1 (TIMP-1), enzymes involved in tissue remodelling, have been previously reported to be overexpressed in the colonic mucosa of patients with Ulcerative colitis (UC). The aim of this study was to determine the relation of MMP-9 and TIMP-1 with UC phenotypes, the disease activity index and routinely tested inflammatory markers in newly diagnosed paediatric patients. The study group comprised 35 children diagnosed with UC and 20 control groups. Serum and faecal concentrations of MMP-9 and TIMP-1 were estimated using enzyme-like immunosorbent assay kits and correlated to the disease activity index (Paediatric Ulcerative Colitis Activity Index, PUCAI), UC phenotype (Paris Classification), inflammatory markers and endoscopic score (Mayo score). Children with UC presented with significantly higher serum and faecal concentrations of studied markers compared to the control group. Both serums, MMP-9 and TIMP-1, were higher in children with more extended and severe lesions in the colon. Furthermore, serum MMP-9 correlated with the Mayo score, Paris classification and C-reactive protein (CRP) levels. Serum TIMP-1 showed correlation with PUCAI, Paris Classification, CRP levels and the erythrocyte sedimentation rate. Serum and faecal levels of MMP-9 and TIMP-1 are useful in discriminating UC patients and non-invasive assessments of disease phenotypes. It seemed that simultaneous measurement of these proteins in combination with other common markers of inflammation could be applied in clinical practice. MDPI 2022-05-09 /pmc/articles/PMC9103541/ /pubmed/35566780 http://dx.doi.org/10.3390/jcm11092655 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Czajkowska, Aleksandra Guzinska-Ustymowicz, Katarzyna Pryczynicz, Anna Lebensztejn, Dariusz Daniluk, Urszula Are Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Useful as Markers in Diagnostic Management of Children with Newly Diagnosed Ulcerative Colitis? |
title | Are Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Useful as Markers in Diagnostic Management of Children with Newly Diagnosed Ulcerative Colitis? |
title_full | Are Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Useful as Markers in Diagnostic Management of Children with Newly Diagnosed Ulcerative Colitis? |
title_fullStr | Are Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Useful as Markers in Diagnostic Management of Children with Newly Diagnosed Ulcerative Colitis? |
title_full_unstemmed | Are Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Useful as Markers in Diagnostic Management of Children with Newly Diagnosed Ulcerative Colitis? |
title_short | Are Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Useful as Markers in Diagnostic Management of Children with Newly Diagnosed Ulcerative Colitis? |
title_sort | are matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 useful as markers in diagnostic management of children with newly diagnosed ulcerative colitis? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103541/ https://www.ncbi.nlm.nih.gov/pubmed/35566780 http://dx.doi.org/10.3390/jcm11092655 |
work_keys_str_mv | AT czajkowskaaleksandra arematrixmetalloproteinase9andtissueinhibitorofmetalloproteinase1usefulasmarkersindiagnosticmanagementofchildrenwithnewlydiagnosedulcerativecolitis AT guzinskaustymowiczkatarzyna arematrixmetalloproteinase9andtissueinhibitorofmetalloproteinase1usefulasmarkersindiagnosticmanagementofchildrenwithnewlydiagnosedulcerativecolitis AT pryczyniczanna arematrixmetalloproteinase9andtissueinhibitorofmetalloproteinase1usefulasmarkersindiagnosticmanagementofchildrenwithnewlydiagnosedulcerativecolitis AT lebensztejndariusz arematrixmetalloproteinase9andtissueinhibitorofmetalloproteinase1usefulasmarkersindiagnosticmanagementofchildrenwithnewlydiagnosedulcerativecolitis AT danilukurszula arematrixmetalloproteinase9andtissueinhibitorofmetalloproteinase1usefulasmarkersindiagnosticmanagementofchildrenwithnewlydiagnosedulcerativecolitis |