Coronary Artery Ectasia: Review of the Non-Atherosclerotic Molecular and Pathophysiologic Concepts

Coronary artery ectasia (CAE) is frequently encountered in clinical practice, conjointly with atherosclerotic CAD (CAD). Given the overlapping cardiovascular risk factors for patients with concomitant CAE and atherosclerotic CAD, a common underlying pathophysiology is often postulated. However, coro...

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Autores principales: Richards, Gavin H. C., Hong, Kathryn L., Henein, Michael Y., Hanratty, Colm, Boles, Usama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103542/
https://www.ncbi.nlm.nih.gov/pubmed/35563583
http://dx.doi.org/10.3390/ijms23095195
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author Richards, Gavin H. C.
Hong, Kathryn L.
Henein, Michael Y.
Hanratty, Colm
Boles, Usama
author_facet Richards, Gavin H. C.
Hong, Kathryn L.
Henein, Michael Y.
Hanratty, Colm
Boles, Usama
author_sort Richards, Gavin H. C.
collection PubMed
description Coronary artery ectasia (CAE) is frequently encountered in clinical practice, conjointly with atherosclerotic CAD (CAD). Given the overlapping cardiovascular risk factors for patients with concomitant CAE and atherosclerotic CAD, a common underlying pathophysiology is often postulated. However, coronary artery ectasia may arise independently, as isolated (pure) CAE, thereby raising suspicions of an alternative mechanism. Herein, we review the existing evidence for the pathophysiology of CAE in order to help direct management strategies towards enhanced detection and treatment.
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spelling pubmed-91035422022-05-14 Coronary Artery Ectasia: Review of the Non-Atherosclerotic Molecular and Pathophysiologic Concepts Richards, Gavin H. C. Hong, Kathryn L. Henein, Michael Y. Hanratty, Colm Boles, Usama Int J Mol Sci Review Coronary artery ectasia (CAE) is frequently encountered in clinical practice, conjointly with atherosclerotic CAD (CAD). Given the overlapping cardiovascular risk factors for patients with concomitant CAE and atherosclerotic CAD, a common underlying pathophysiology is often postulated. However, coronary artery ectasia may arise independently, as isolated (pure) CAE, thereby raising suspicions of an alternative mechanism. Herein, we review the existing evidence for the pathophysiology of CAE in order to help direct management strategies towards enhanced detection and treatment. MDPI 2022-05-06 /pmc/articles/PMC9103542/ /pubmed/35563583 http://dx.doi.org/10.3390/ijms23095195 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Richards, Gavin H. C.
Hong, Kathryn L.
Henein, Michael Y.
Hanratty, Colm
Boles, Usama
Coronary Artery Ectasia: Review of the Non-Atherosclerotic Molecular and Pathophysiologic Concepts
title Coronary Artery Ectasia: Review of the Non-Atherosclerotic Molecular and Pathophysiologic Concepts
title_full Coronary Artery Ectasia: Review of the Non-Atherosclerotic Molecular and Pathophysiologic Concepts
title_fullStr Coronary Artery Ectasia: Review of the Non-Atherosclerotic Molecular and Pathophysiologic Concepts
title_full_unstemmed Coronary Artery Ectasia: Review of the Non-Atherosclerotic Molecular and Pathophysiologic Concepts
title_short Coronary Artery Ectasia: Review of the Non-Atherosclerotic Molecular and Pathophysiologic Concepts
title_sort coronary artery ectasia: review of the non-atherosclerotic molecular and pathophysiologic concepts
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103542/
https://www.ncbi.nlm.nih.gov/pubmed/35563583
http://dx.doi.org/10.3390/ijms23095195
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