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Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field
The atherosclerotic vascular disease is a cardiovascular continuum in which the main role is attributed to atherosclerosis, from its appearance to its associated complications. The increasing prevalence of cardiovascular risk factors, population ageing, and burden on both the economy and the healthc...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103799/ https://www.ncbi.nlm.nih.gov/pubmed/35563387 http://dx.doi.org/10.3390/ijms23094998 |
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author | Adam, Cristina Andreea Șalaru, Delia Lidia Prisacariu, Cristina Marcu, Dragoș Traian Marius Sascău, Radu Andy Stătescu, Cristian |
author_facet | Adam, Cristina Andreea Șalaru, Delia Lidia Prisacariu, Cristina Marcu, Dragoș Traian Marius Sascău, Radu Andy Stătescu, Cristian |
author_sort | Adam, Cristina Andreea |
collection | PubMed |
description | The atherosclerotic vascular disease is a cardiovascular continuum in which the main role is attributed to atherosclerosis, from its appearance to its associated complications. The increasing prevalence of cardiovascular risk factors, population ageing, and burden on both the economy and the healthcare system have led to the development of new diagnostic and therapeutic strategies in the field. The better understanding or discovery of new pathophysiological mechanisms and molecules modulating various signaling pathways involved in atherosclerosis have led to the development of potential new biomarkers, with key role in early, subclinical diagnosis. The evolution of technological processes in medicine has shifted the attention of researchers from the profiling of classical risk factors to the identification of new biomarkers such as midregional pro-adrenomedullin, midkine, stromelysin-2, pentraxin 3, inflammasomes, or endothelial cell-derived extracellular vesicles. These molecules are seen as future therapeutic targets associated with decreased morbidity and mortality through early diagnosis of atherosclerotic lesions and future research directions. |
format | Online Article Text |
id | pubmed-9103799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91037992022-05-14 Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field Adam, Cristina Andreea Șalaru, Delia Lidia Prisacariu, Cristina Marcu, Dragoș Traian Marius Sascău, Radu Andy Stătescu, Cristian Int J Mol Sci Review The atherosclerotic vascular disease is a cardiovascular continuum in which the main role is attributed to atherosclerosis, from its appearance to its associated complications. The increasing prevalence of cardiovascular risk factors, population ageing, and burden on both the economy and the healthcare system have led to the development of new diagnostic and therapeutic strategies in the field. The better understanding or discovery of new pathophysiological mechanisms and molecules modulating various signaling pathways involved in atherosclerosis have led to the development of potential new biomarkers, with key role in early, subclinical diagnosis. The evolution of technological processes in medicine has shifted the attention of researchers from the profiling of classical risk factors to the identification of new biomarkers such as midregional pro-adrenomedullin, midkine, stromelysin-2, pentraxin 3, inflammasomes, or endothelial cell-derived extracellular vesicles. These molecules are seen as future therapeutic targets associated with decreased morbidity and mortality through early diagnosis of atherosclerotic lesions and future research directions. MDPI 2022-04-30 /pmc/articles/PMC9103799/ /pubmed/35563387 http://dx.doi.org/10.3390/ijms23094998 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Adam, Cristina Andreea Șalaru, Delia Lidia Prisacariu, Cristina Marcu, Dragoș Traian Marius Sascău, Radu Andy Stătescu, Cristian Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field |
title | Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field |
title_full | Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field |
title_fullStr | Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field |
title_full_unstemmed | Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field |
title_short | Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field |
title_sort | novel biomarkers of atherosclerotic vascular disease—latest insights in the research field |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103799/ https://www.ncbi.nlm.nih.gov/pubmed/35563387 http://dx.doi.org/10.3390/ijms23094998 |
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