Cargando…

Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field

The atherosclerotic vascular disease is a cardiovascular continuum in which the main role is attributed to atherosclerosis, from its appearance to its associated complications. The increasing prevalence of cardiovascular risk factors, population ageing, and burden on both the economy and the healthc...

Descripción completa

Detalles Bibliográficos
Autores principales: Adam, Cristina Andreea, Șalaru, Delia Lidia, Prisacariu, Cristina, Marcu, Dragoș Traian Marius, Sascău, Radu Andy, Stătescu, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103799/
https://www.ncbi.nlm.nih.gov/pubmed/35563387
http://dx.doi.org/10.3390/ijms23094998
_version_ 1784707638546661376
author Adam, Cristina Andreea
Șalaru, Delia Lidia
Prisacariu, Cristina
Marcu, Dragoș Traian Marius
Sascău, Radu Andy
Stătescu, Cristian
author_facet Adam, Cristina Andreea
Șalaru, Delia Lidia
Prisacariu, Cristina
Marcu, Dragoș Traian Marius
Sascău, Radu Andy
Stătescu, Cristian
author_sort Adam, Cristina Andreea
collection PubMed
description The atherosclerotic vascular disease is a cardiovascular continuum in which the main role is attributed to atherosclerosis, from its appearance to its associated complications. The increasing prevalence of cardiovascular risk factors, population ageing, and burden on both the economy and the healthcare system have led to the development of new diagnostic and therapeutic strategies in the field. The better understanding or discovery of new pathophysiological mechanisms and molecules modulating various signaling pathways involved in atherosclerosis have led to the development of potential new biomarkers, with key role in early, subclinical diagnosis. The evolution of technological processes in medicine has shifted the attention of researchers from the profiling of classical risk factors to the identification of new biomarkers such as midregional pro-adrenomedullin, midkine, stromelysin-2, pentraxin 3, inflammasomes, or endothelial cell-derived extracellular vesicles. These molecules are seen as future therapeutic targets associated with decreased morbidity and mortality through early diagnosis of atherosclerotic lesions and future research directions.
format Online
Article
Text
id pubmed-9103799
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91037992022-05-14 Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field Adam, Cristina Andreea Șalaru, Delia Lidia Prisacariu, Cristina Marcu, Dragoș Traian Marius Sascău, Radu Andy Stătescu, Cristian Int J Mol Sci Review The atherosclerotic vascular disease is a cardiovascular continuum in which the main role is attributed to atherosclerosis, from its appearance to its associated complications. The increasing prevalence of cardiovascular risk factors, population ageing, and burden on both the economy and the healthcare system have led to the development of new diagnostic and therapeutic strategies in the field. The better understanding or discovery of new pathophysiological mechanisms and molecules modulating various signaling pathways involved in atherosclerosis have led to the development of potential new biomarkers, with key role in early, subclinical diagnosis. The evolution of technological processes in medicine has shifted the attention of researchers from the profiling of classical risk factors to the identification of new biomarkers such as midregional pro-adrenomedullin, midkine, stromelysin-2, pentraxin 3, inflammasomes, or endothelial cell-derived extracellular vesicles. These molecules are seen as future therapeutic targets associated with decreased morbidity and mortality through early diagnosis of atherosclerotic lesions and future research directions. MDPI 2022-04-30 /pmc/articles/PMC9103799/ /pubmed/35563387 http://dx.doi.org/10.3390/ijms23094998 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Adam, Cristina Andreea
Șalaru, Delia Lidia
Prisacariu, Cristina
Marcu, Dragoș Traian Marius
Sascău, Radu Andy
Stătescu, Cristian
Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field
title Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field
title_full Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field
title_fullStr Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field
title_full_unstemmed Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field
title_short Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field
title_sort novel biomarkers of atherosclerotic vascular disease—latest insights in the research field
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103799/
https://www.ncbi.nlm.nih.gov/pubmed/35563387
http://dx.doi.org/10.3390/ijms23094998
work_keys_str_mv AT adamcristinaandreea novelbiomarkersofatheroscleroticvasculardiseaselatestinsightsintheresearchfield
AT salarudelialidia novelbiomarkersofatheroscleroticvasculardiseaselatestinsightsintheresearchfield
AT prisacariucristina novelbiomarkersofatheroscleroticvasculardiseaselatestinsightsintheresearchfield
AT marcudragostraianmarius novelbiomarkersofatheroscleroticvasculardiseaselatestinsightsintheresearchfield
AT sascauraduandy novelbiomarkersofatheroscleroticvasculardiseaselatestinsightsintheresearchfield
AT statescucristian novelbiomarkersofatheroscleroticvasculardiseaselatestinsightsintheresearchfield