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Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk

Since Otto Warburg’s first report on the increased uptake of glucose and lactate release by cancer cells, dysregulated metabolism has been acknowledged as a hallmark of cancer that promotes proliferation and metastasis. Over the last century, studies have shown that cancer metabolism is complex, and...

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Autores principales: Gu, Inah, Gregory, Emory, Atwood, Casey, Lee, Sun-Ok, Song, Young Hye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103817/
https://www.ncbi.nlm.nih.gov/pubmed/35565690
http://dx.doi.org/10.3390/nu14091722
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author Gu, Inah
Gregory, Emory
Atwood, Casey
Lee, Sun-Ok
Song, Young Hye
author_facet Gu, Inah
Gregory, Emory
Atwood, Casey
Lee, Sun-Ok
Song, Young Hye
author_sort Gu, Inah
collection PubMed
description Since Otto Warburg’s first report on the increased uptake of glucose and lactate release by cancer cells, dysregulated metabolism has been acknowledged as a hallmark of cancer that promotes proliferation and metastasis. Over the last century, studies have shown that cancer metabolism is complex, and by-products of glucose and glutamine catabolism induce a cascade of both pro- and antitumorigenic processes. Some vitamins, which have traditionally been praised for preventing and inhibiting the proliferation of cancer cells, have also been proven to cause cancer progression in a dose-dependent manner. Importantly, recent findings have shown that the nervous system is a key player in tumor growth and metastasis via perineural invasion and tumor innervation. However, the link between cancer–nerve crosstalk and tumor metabolism remains unclear. Here, we discuss the roles of relatively underappreciated metabolites in cancer–nerve crosstalk, including lactate, vitamins, and amino acids, and propose the investigation of nutrients in cancer–nerve crosstalk based on their tumorigenicity and neuroregulatory capabilities. Continued research into the metabolic regulation of cancer–nerve crosstalk will provide a more comprehensive understanding of tumor mechanisms and may lead to the identification of potential targets for future cancer therapies.
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spelling pubmed-91038172022-05-14 Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk Gu, Inah Gregory, Emory Atwood, Casey Lee, Sun-Ok Song, Young Hye Nutrients Review Since Otto Warburg’s first report on the increased uptake of glucose and lactate release by cancer cells, dysregulated metabolism has been acknowledged as a hallmark of cancer that promotes proliferation and metastasis. Over the last century, studies have shown that cancer metabolism is complex, and by-products of glucose and glutamine catabolism induce a cascade of both pro- and antitumorigenic processes. Some vitamins, which have traditionally been praised for preventing and inhibiting the proliferation of cancer cells, have also been proven to cause cancer progression in a dose-dependent manner. Importantly, recent findings have shown that the nervous system is a key player in tumor growth and metastasis via perineural invasion and tumor innervation. However, the link between cancer–nerve crosstalk and tumor metabolism remains unclear. Here, we discuss the roles of relatively underappreciated metabolites in cancer–nerve crosstalk, including lactate, vitamins, and amino acids, and propose the investigation of nutrients in cancer–nerve crosstalk based on their tumorigenicity and neuroregulatory capabilities. Continued research into the metabolic regulation of cancer–nerve crosstalk will provide a more comprehensive understanding of tumor mechanisms and may lead to the identification of potential targets for future cancer therapies. MDPI 2022-04-21 /pmc/articles/PMC9103817/ /pubmed/35565690 http://dx.doi.org/10.3390/nu14091722 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gu, Inah
Gregory, Emory
Atwood, Casey
Lee, Sun-Ok
Song, Young Hye
Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk
title Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk
title_full Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk
title_fullStr Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk
title_full_unstemmed Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk
title_short Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk
title_sort exploring the role of metabolites in cancer and the associated nerve crosstalk
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103817/
https://www.ncbi.nlm.nih.gov/pubmed/35565690
http://dx.doi.org/10.3390/nu14091722
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