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Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk
Since Otto Warburg’s first report on the increased uptake of glucose and lactate release by cancer cells, dysregulated metabolism has been acknowledged as a hallmark of cancer that promotes proliferation and metastasis. Over the last century, studies have shown that cancer metabolism is complex, and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103817/ https://www.ncbi.nlm.nih.gov/pubmed/35565690 http://dx.doi.org/10.3390/nu14091722 |
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author | Gu, Inah Gregory, Emory Atwood, Casey Lee, Sun-Ok Song, Young Hye |
author_facet | Gu, Inah Gregory, Emory Atwood, Casey Lee, Sun-Ok Song, Young Hye |
author_sort | Gu, Inah |
collection | PubMed |
description | Since Otto Warburg’s first report on the increased uptake of glucose and lactate release by cancer cells, dysregulated metabolism has been acknowledged as a hallmark of cancer that promotes proliferation and metastasis. Over the last century, studies have shown that cancer metabolism is complex, and by-products of glucose and glutamine catabolism induce a cascade of both pro- and antitumorigenic processes. Some vitamins, which have traditionally been praised for preventing and inhibiting the proliferation of cancer cells, have also been proven to cause cancer progression in a dose-dependent manner. Importantly, recent findings have shown that the nervous system is a key player in tumor growth and metastasis via perineural invasion and tumor innervation. However, the link between cancer–nerve crosstalk and tumor metabolism remains unclear. Here, we discuss the roles of relatively underappreciated metabolites in cancer–nerve crosstalk, including lactate, vitamins, and amino acids, and propose the investigation of nutrients in cancer–nerve crosstalk based on their tumorigenicity and neuroregulatory capabilities. Continued research into the metabolic regulation of cancer–nerve crosstalk will provide a more comprehensive understanding of tumor mechanisms and may lead to the identification of potential targets for future cancer therapies. |
format | Online Article Text |
id | pubmed-9103817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91038172022-05-14 Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk Gu, Inah Gregory, Emory Atwood, Casey Lee, Sun-Ok Song, Young Hye Nutrients Review Since Otto Warburg’s first report on the increased uptake of glucose and lactate release by cancer cells, dysregulated metabolism has been acknowledged as a hallmark of cancer that promotes proliferation and metastasis. Over the last century, studies have shown that cancer metabolism is complex, and by-products of glucose and glutamine catabolism induce a cascade of both pro- and antitumorigenic processes. Some vitamins, which have traditionally been praised for preventing and inhibiting the proliferation of cancer cells, have also been proven to cause cancer progression in a dose-dependent manner. Importantly, recent findings have shown that the nervous system is a key player in tumor growth and metastasis via perineural invasion and tumor innervation. However, the link between cancer–nerve crosstalk and tumor metabolism remains unclear. Here, we discuss the roles of relatively underappreciated metabolites in cancer–nerve crosstalk, including lactate, vitamins, and amino acids, and propose the investigation of nutrients in cancer–nerve crosstalk based on their tumorigenicity and neuroregulatory capabilities. Continued research into the metabolic regulation of cancer–nerve crosstalk will provide a more comprehensive understanding of tumor mechanisms and may lead to the identification of potential targets for future cancer therapies. MDPI 2022-04-21 /pmc/articles/PMC9103817/ /pubmed/35565690 http://dx.doi.org/10.3390/nu14091722 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gu, Inah Gregory, Emory Atwood, Casey Lee, Sun-Ok Song, Young Hye Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk |
title | Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk |
title_full | Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk |
title_fullStr | Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk |
title_full_unstemmed | Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk |
title_short | Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk |
title_sort | exploring the role of metabolites in cancer and the associated nerve crosstalk |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103817/ https://www.ncbi.nlm.nih.gov/pubmed/35565690 http://dx.doi.org/10.3390/nu14091722 |
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