Cargando…

RhoA Signaling in Neurodegenerative Diseases

Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction pathways that influence a diverse range of cellular functions. RhoA and many of its downstream effector proteins are highly expressed in the nervous system, implying an imp...

Descripción completa

Detalles Bibliográficos
Autores principales: Schmidt, Sissel Ida, Blaabjerg, Morten, Freude, Kristine, Meyer, Morten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103838/
https://www.ncbi.nlm.nih.gov/pubmed/35563826
http://dx.doi.org/10.3390/cells11091520
_version_ 1784707648020545536
author Schmidt, Sissel Ida
Blaabjerg, Morten
Freude, Kristine
Meyer, Morten
author_facet Schmidt, Sissel Ida
Blaabjerg, Morten
Freude, Kristine
Meyer, Morten
author_sort Schmidt, Sissel Ida
collection PubMed
description Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction pathways that influence a diverse range of cellular functions. RhoA and many of its downstream effector proteins are highly expressed in the nervous system, implying an important role for RhoA signaling in neurons and glial cells. Indeed, emerging evidence points toward a role of aberrant RhoA signaling in neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. In this review, we summarize the current knowledge of RhoA regulation and downstream cellular functions with an emphasis on the role of RhoA signaling in neurodegenerative diseases and the therapeutic potential of RhoA inhibition in neurodegeneration.
format Online
Article
Text
id pubmed-9103838
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91038382022-05-14 RhoA Signaling in Neurodegenerative Diseases Schmidt, Sissel Ida Blaabjerg, Morten Freude, Kristine Meyer, Morten Cells Review Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction pathways that influence a diverse range of cellular functions. RhoA and many of its downstream effector proteins are highly expressed in the nervous system, implying an important role for RhoA signaling in neurons and glial cells. Indeed, emerging evidence points toward a role of aberrant RhoA signaling in neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. In this review, we summarize the current knowledge of RhoA regulation and downstream cellular functions with an emphasis on the role of RhoA signaling in neurodegenerative diseases and the therapeutic potential of RhoA inhibition in neurodegeneration. MDPI 2022-05-01 /pmc/articles/PMC9103838/ /pubmed/35563826 http://dx.doi.org/10.3390/cells11091520 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schmidt, Sissel Ida
Blaabjerg, Morten
Freude, Kristine
Meyer, Morten
RhoA Signaling in Neurodegenerative Diseases
title RhoA Signaling in Neurodegenerative Diseases
title_full RhoA Signaling in Neurodegenerative Diseases
title_fullStr RhoA Signaling in Neurodegenerative Diseases
title_full_unstemmed RhoA Signaling in Neurodegenerative Diseases
title_short RhoA Signaling in Neurodegenerative Diseases
title_sort rhoa signaling in neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103838/
https://www.ncbi.nlm.nih.gov/pubmed/35563826
http://dx.doi.org/10.3390/cells11091520
work_keys_str_mv AT schmidtsisselida rhoasignalinginneurodegenerativediseases
AT blaabjergmorten rhoasignalinginneurodegenerativediseases
AT freudekristine rhoasignalinginneurodegenerativediseases
AT meyermorten rhoasignalinginneurodegenerativediseases