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RhoA Signaling in Neurodegenerative Diseases
Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction pathways that influence a diverse range of cellular functions. RhoA and many of its downstream effector proteins are highly expressed in the nervous system, implying an imp...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103838/ https://www.ncbi.nlm.nih.gov/pubmed/35563826 http://dx.doi.org/10.3390/cells11091520 |
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author | Schmidt, Sissel Ida Blaabjerg, Morten Freude, Kristine Meyer, Morten |
author_facet | Schmidt, Sissel Ida Blaabjerg, Morten Freude, Kristine Meyer, Morten |
author_sort | Schmidt, Sissel Ida |
collection | PubMed |
description | Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction pathways that influence a diverse range of cellular functions. RhoA and many of its downstream effector proteins are highly expressed in the nervous system, implying an important role for RhoA signaling in neurons and glial cells. Indeed, emerging evidence points toward a role of aberrant RhoA signaling in neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. In this review, we summarize the current knowledge of RhoA regulation and downstream cellular functions with an emphasis on the role of RhoA signaling in neurodegenerative diseases and the therapeutic potential of RhoA inhibition in neurodegeneration. |
format | Online Article Text |
id | pubmed-9103838 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91038382022-05-14 RhoA Signaling in Neurodegenerative Diseases Schmidt, Sissel Ida Blaabjerg, Morten Freude, Kristine Meyer, Morten Cells Review Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction pathways that influence a diverse range of cellular functions. RhoA and many of its downstream effector proteins are highly expressed in the nervous system, implying an important role for RhoA signaling in neurons and glial cells. Indeed, emerging evidence points toward a role of aberrant RhoA signaling in neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. In this review, we summarize the current knowledge of RhoA regulation and downstream cellular functions with an emphasis on the role of RhoA signaling in neurodegenerative diseases and the therapeutic potential of RhoA inhibition in neurodegeneration. MDPI 2022-05-01 /pmc/articles/PMC9103838/ /pubmed/35563826 http://dx.doi.org/10.3390/cells11091520 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Schmidt, Sissel Ida Blaabjerg, Morten Freude, Kristine Meyer, Morten RhoA Signaling in Neurodegenerative Diseases |
title | RhoA Signaling in Neurodegenerative Diseases |
title_full | RhoA Signaling in Neurodegenerative Diseases |
title_fullStr | RhoA Signaling in Neurodegenerative Diseases |
title_full_unstemmed | RhoA Signaling in Neurodegenerative Diseases |
title_short | RhoA Signaling in Neurodegenerative Diseases |
title_sort | rhoa signaling in neurodegenerative diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103838/ https://www.ncbi.nlm.nih.gov/pubmed/35563826 http://dx.doi.org/10.3390/cells11091520 |
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