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Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey

Background: The European Society for Clinical Nutrition and Metabolism database for chronic intestinal failure (CIF) was analyzed to investigate factors associated with nutritional status and the intravenous supplementation (IVS) dependency in children. Methods: Data collected: demographics, CIF mec...

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Autores principales: Lezo, Antonella, Diamanti, Antonella, Marinier, Evelyne M., Tabbers, Merit, Guz-Mark, Anat, Gandullia, Paolo, Spagnuolo, Maria I., Protheroe, Sue, Peretti, Noel, Merras-Salmio, Laura, Hulst, Jessie M., Kolaček, Sanja, Ee, Looi C., Lawrence, Joanna, Hind, Jonathan, D’Antiga, Lorenzo, Verlato, Giovanna, Pukite, Ieva, Di Leo, Grazia, Vanuytsel, Tim, Doitchinova-Simeonova, Maryana K., Ellegard, Lars, Masconale, Luisa, Maíz-Jiménez, María, Cooper, Sheldon C., Brillanti, Giorgia, Nardi, Elena, Sasdelli, Anna S., Lal, Simon, Pironi, Loris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103944/
https://www.ncbi.nlm.nih.gov/pubmed/35565856
http://dx.doi.org/10.3390/nu14091889
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author Lezo, Antonella
Diamanti, Antonella
Marinier, Evelyne M.
Tabbers, Merit
Guz-Mark, Anat
Gandullia, Paolo
Spagnuolo, Maria I.
Protheroe, Sue
Peretti, Noel
Merras-Salmio, Laura
Hulst, Jessie M.
Kolaček, Sanja
Ee, Looi C.
Lawrence, Joanna
Hind, Jonathan
D’Antiga, Lorenzo
Verlato, Giovanna
Pukite, Ieva
Di Leo, Grazia
Vanuytsel, Tim
Doitchinova-Simeonova, Maryana K.
Ellegard, Lars
Masconale, Luisa
Maíz-Jiménez, María
Cooper, Sheldon C.
Brillanti, Giorgia
Nardi, Elena
Sasdelli, Anna S.
Lal, Simon
Pironi, Loris
author_facet Lezo, Antonella
Diamanti, Antonella
Marinier, Evelyne M.
Tabbers, Merit
Guz-Mark, Anat
Gandullia, Paolo
Spagnuolo, Maria I.
Protheroe, Sue
Peretti, Noel
Merras-Salmio, Laura
Hulst, Jessie M.
Kolaček, Sanja
Ee, Looi C.
Lawrence, Joanna
Hind, Jonathan
D’Antiga, Lorenzo
Verlato, Giovanna
Pukite, Ieva
Di Leo, Grazia
Vanuytsel, Tim
Doitchinova-Simeonova, Maryana K.
Ellegard, Lars
Masconale, Luisa
Maíz-Jiménez, María
Cooper, Sheldon C.
Brillanti, Giorgia
Nardi, Elena
Sasdelli, Anna S.
Lal, Simon
Pironi, Loris
author_sort Lezo, Antonella
collection PubMed
description Background: The European Society for Clinical Nutrition and Metabolism database for chronic intestinal failure (CIF) was analyzed to investigate factors associated with nutritional status and the intravenous supplementation (IVS) dependency in children. Methods: Data collected: demographics, CIF mechanism, home parenteral nutrition program, z-scores of weight-for-age (WFA), length or height-for-age (LFA/HFA), and body mass index-for-age (BMI-FA). IVS dependency was calculated as the ratio of daily total IVS energy over estimated resting energy expenditure (%IVSE/REE). Results: Five hundred and fifty-eight patients were included, 57.2% of whom were male. CIF mechanisms at age 1–4 and 14–18 years, respectively: SBS 63.3%, 37.9%; dysmotility or mucosal disease: 36.7%, 62.1%. One-third had WFA and/or LFA/HFA z-scores < −2. One-third had %IVSE/REE > 125%. Multivariate analysis showed that mechanism of CIF was associated with WFA and/or LFA/HFA z-scores (negatively with mucosal disease) and %IVSE/REE (higher for dysmotility and lower in SBS with colon in continuity), while z-scores were negatively associated with %IVSE/REE. Conclusions: The main mechanism of CIF at young age was short bowel syndrome (SBS), whereas most patients facing adulthood had intestinal dysmotility or mucosal disease. One-third were underweight or stunted and had high IVS dependency. Considering that IVS dependency was associated with both CIF mechanisms and nutritional status, IVS dependency is suggested as a potential marker for CIF severity in children.
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spelling pubmed-91039442022-05-14 Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey Lezo, Antonella Diamanti, Antonella Marinier, Evelyne M. Tabbers, Merit Guz-Mark, Anat Gandullia, Paolo Spagnuolo, Maria I. Protheroe, Sue Peretti, Noel Merras-Salmio, Laura Hulst, Jessie M. Kolaček, Sanja Ee, Looi C. Lawrence, Joanna Hind, Jonathan D’Antiga, Lorenzo Verlato, Giovanna Pukite, Ieva Di Leo, Grazia Vanuytsel, Tim Doitchinova-Simeonova, Maryana K. Ellegard, Lars Masconale, Luisa Maíz-Jiménez, María Cooper, Sheldon C. Brillanti, Giorgia Nardi, Elena Sasdelli, Anna S. Lal, Simon Pironi, Loris Nutrients Article Background: The European Society for Clinical Nutrition and Metabolism database for chronic intestinal failure (CIF) was analyzed to investigate factors associated with nutritional status and the intravenous supplementation (IVS) dependency in children. Methods: Data collected: demographics, CIF mechanism, home parenteral nutrition program, z-scores of weight-for-age (WFA), length or height-for-age (LFA/HFA), and body mass index-for-age (BMI-FA). IVS dependency was calculated as the ratio of daily total IVS energy over estimated resting energy expenditure (%IVSE/REE). Results: Five hundred and fifty-eight patients were included, 57.2% of whom were male. CIF mechanisms at age 1–4 and 14–18 years, respectively: SBS 63.3%, 37.9%; dysmotility or mucosal disease: 36.7%, 62.1%. One-third had WFA and/or LFA/HFA z-scores < −2. One-third had %IVSE/REE > 125%. Multivariate analysis showed that mechanism of CIF was associated with WFA and/or LFA/HFA z-scores (negatively with mucosal disease) and %IVSE/REE (higher for dysmotility and lower in SBS with colon in continuity), while z-scores were negatively associated with %IVSE/REE. Conclusions: The main mechanism of CIF at young age was short bowel syndrome (SBS), whereas most patients facing adulthood had intestinal dysmotility or mucosal disease. One-third were underweight or stunted and had high IVS dependency. Considering that IVS dependency was associated with both CIF mechanisms and nutritional status, IVS dependency is suggested as a potential marker for CIF severity in children. MDPI 2022-04-30 /pmc/articles/PMC9103944/ /pubmed/35565856 http://dx.doi.org/10.3390/nu14091889 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lezo, Antonella
Diamanti, Antonella
Marinier, Evelyne M.
Tabbers, Merit
Guz-Mark, Anat
Gandullia, Paolo
Spagnuolo, Maria I.
Protheroe, Sue
Peretti, Noel
Merras-Salmio, Laura
Hulst, Jessie M.
Kolaček, Sanja
Ee, Looi C.
Lawrence, Joanna
Hind, Jonathan
D’Antiga, Lorenzo
Verlato, Giovanna
Pukite, Ieva
Di Leo, Grazia
Vanuytsel, Tim
Doitchinova-Simeonova, Maryana K.
Ellegard, Lars
Masconale, Luisa
Maíz-Jiménez, María
Cooper, Sheldon C.
Brillanti, Giorgia
Nardi, Elena
Sasdelli, Anna S.
Lal, Simon
Pironi, Loris
Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey
title Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey
title_full Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey
title_fullStr Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey
title_full_unstemmed Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey
title_short Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey
title_sort chronic intestinal failure in children: an international multicenter cross-sectional survey
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103944/
https://www.ncbi.nlm.nih.gov/pubmed/35565856
http://dx.doi.org/10.3390/nu14091889
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