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Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey
Background: The European Society for Clinical Nutrition and Metabolism database for chronic intestinal failure (CIF) was analyzed to investigate factors associated with nutritional status and the intravenous supplementation (IVS) dependency in children. Methods: Data collected: demographics, CIF mec...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103944/ https://www.ncbi.nlm.nih.gov/pubmed/35565856 http://dx.doi.org/10.3390/nu14091889 |
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author | Lezo, Antonella Diamanti, Antonella Marinier, Evelyne M. Tabbers, Merit Guz-Mark, Anat Gandullia, Paolo Spagnuolo, Maria I. Protheroe, Sue Peretti, Noel Merras-Salmio, Laura Hulst, Jessie M. Kolaček, Sanja Ee, Looi C. Lawrence, Joanna Hind, Jonathan D’Antiga, Lorenzo Verlato, Giovanna Pukite, Ieva Di Leo, Grazia Vanuytsel, Tim Doitchinova-Simeonova, Maryana K. Ellegard, Lars Masconale, Luisa Maíz-Jiménez, María Cooper, Sheldon C. Brillanti, Giorgia Nardi, Elena Sasdelli, Anna S. Lal, Simon Pironi, Loris |
author_facet | Lezo, Antonella Diamanti, Antonella Marinier, Evelyne M. Tabbers, Merit Guz-Mark, Anat Gandullia, Paolo Spagnuolo, Maria I. Protheroe, Sue Peretti, Noel Merras-Salmio, Laura Hulst, Jessie M. Kolaček, Sanja Ee, Looi C. Lawrence, Joanna Hind, Jonathan D’Antiga, Lorenzo Verlato, Giovanna Pukite, Ieva Di Leo, Grazia Vanuytsel, Tim Doitchinova-Simeonova, Maryana K. Ellegard, Lars Masconale, Luisa Maíz-Jiménez, María Cooper, Sheldon C. Brillanti, Giorgia Nardi, Elena Sasdelli, Anna S. Lal, Simon Pironi, Loris |
author_sort | Lezo, Antonella |
collection | PubMed |
description | Background: The European Society for Clinical Nutrition and Metabolism database for chronic intestinal failure (CIF) was analyzed to investigate factors associated with nutritional status and the intravenous supplementation (IVS) dependency in children. Methods: Data collected: demographics, CIF mechanism, home parenteral nutrition program, z-scores of weight-for-age (WFA), length or height-for-age (LFA/HFA), and body mass index-for-age (BMI-FA). IVS dependency was calculated as the ratio of daily total IVS energy over estimated resting energy expenditure (%IVSE/REE). Results: Five hundred and fifty-eight patients were included, 57.2% of whom were male. CIF mechanisms at age 1–4 and 14–18 years, respectively: SBS 63.3%, 37.9%; dysmotility or mucosal disease: 36.7%, 62.1%. One-third had WFA and/or LFA/HFA z-scores < −2. One-third had %IVSE/REE > 125%. Multivariate analysis showed that mechanism of CIF was associated with WFA and/or LFA/HFA z-scores (negatively with mucosal disease) and %IVSE/REE (higher for dysmotility and lower in SBS with colon in continuity), while z-scores were negatively associated with %IVSE/REE. Conclusions: The main mechanism of CIF at young age was short bowel syndrome (SBS), whereas most patients facing adulthood had intestinal dysmotility or mucosal disease. One-third were underweight or stunted and had high IVS dependency. Considering that IVS dependency was associated with both CIF mechanisms and nutritional status, IVS dependency is suggested as a potential marker for CIF severity in children. |
format | Online Article Text |
id | pubmed-9103944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91039442022-05-14 Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey Lezo, Antonella Diamanti, Antonella Marinier, Evelyne M. Tabbers, Merit Guz-Mark, Anat Gandullia, Paolo Spagnuolo, Maria I. Protheroe, Sue Peretti, Noel Merras-Salmio, Laura Hulst, Jessie M. Kolaček, Sanja Ee, Looi C. Lawrence, Joanna Hind, Jonathan D’Antiga, Lorenzo Verlato, Giovanna Pukite, Ieva Di Leo, Grazia Vanuytsel, Tim Doitchinova-Simeonova, Maryana K. Ellegard, Lars Masconale, Luisa Maíz-Jiménez, María Cooper, Sheldon C. Brillanti, Giorgia Nardi, Elena Sasdelli, Anna S. Lal, Simon Pironi, Loris Nutrients Article Background: The European Society for Clinical Nutrition and Metabolism database for chronic intestinal failure (CIF) was analyzed to investigate factors associated with nutritional status and the intravenous supplementation (IVS) dependency in children. Methods: Data collected: demographics, CIF mechanism, home parenteral nutrition program, z-scores of weight-for-age (WFA), length or height-for-age (LFA/HFA), and body mass index-for-age (BMI-FA). IVS dependency was calculated as the ratio of daily total IVS energy over estimated resting energy expenditure (%IVSE/REE). Results: Five hundred and fifty-eight patients were included, 57.2% of whom were male. CIF mechanisms at age 1–4 and 14–18 years, respectively: SBS 63.3%, 37.9%; dysmotility or mucosal disease: 36.7%, 62.1%. One-third had WFA and/or LFA/HFA z-scores < −2. One-third had %IVSE/REE > 125%. Multivariate analysis showed that mechanism of CIF was associated with WFA and/or LFA/HFA z-scores (negatively with mucosal disease) and %IVSE/REE (higher for dysmotility and lower in SBS with colon in continuity), while z-scores were negatively associated with %IVSE/REE. Conclusions: The main mechanism of CIF at young age was short bowel syndrome (SBS), whereas most patients facing adulthood had intestinal dysmotility or mucosal disease. One-third were underweight or stunted and had high IVS dependency. Considering that IVS dependency was associated with both CIF mechanisms and nutritional status, IVS dependency is suggested as a potential marker for CIF severity in children. MDPI 2022-04-30 /pmc/articles/PMC9103944/ /pubmed/35565856 http://dx.doi.org/10.3390/nu14091889 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lezo, Antonella Diamanti, Antonella Marinier, Evelyne M. Tabbers, Merit Guz-Mark, Anat Gandullia, Paolo Spagnuolo, Maria I. Protheroe, Sue Peretti, Noel Merras-Salmio, Laura Hulst, Jessie M. Kolaček, Sanja Ee, Looi C. Lawrence, Joanna Hind, Jonathan D’Antiga, Lorenzo Verlato, Giovanna Pukite, Ieva Di Leo, Grazia Vanuytsel, Tim Doitchinova-Simeonova, Maryana K. Ellegard, Lars Masconale, Luisa Maíz-Jiménez, María Cooper, Sheldon C. Brillanti, Giorgia Nardi, Elena Sasdelli, Anna S. Lal, Simon Pironi, Loris Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey |
title | Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey |
title_full | Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey |
title_fullStr | Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey |
title_full_unstemmed | Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey |
title_short | Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey |
title_sort | chronic intestinal failure in children: an international multicenter cross-sectional survey |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103944/ https://www.ncbi.nlm.nih.gov/pubmed/35565856 http://dx.doi.org/10.3390/nu14091889 |
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