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Association between the Right Ventricular Longitudinal Shortening Fraction and Mortality in Acute Respiratory Distress Syndrome Related to COVID-19 Infection: A Prospective Study

Introduction: Right ventricular systolic dysfunction (RVsD) increases acute respiratory distress syndrome mortality in COVID-19 infection (CARDS). The RV longitudinal shortening fraction (RV-LSF) is an angle-independent and automatically calculated speckle-tracking parameter. We explored the associa...

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Autores principales: Beyls, Christophe, Daumin, Camille, Hermida, Alexis, Booz, Thomas, Ghesquieres, Tristan, Crombet, Maxime, Martin, Nicolas, Huette, Pierre, Jounieaux, Vincent, Dupont, Hervé, Abou-Arab, Osama, Mahjoub, Yazine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103975/
https://www.ncbi.nlm.nih.gov/pubmed/35566751
http://dx.doi.org/10.3390/jcm11092625
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author Beyls, Christophe
Daumin, Camille
Hermida, Alexis
Booz, Thomas
Ghesquieres, Tristan
Crombet, Maxime
Martin, Nicolas
Huette, Pierre
Jounieaux, Vincent
Dupont, Hervé
Abou-Arab, Osama
Mahjoub, Yazine
author_facet Beyls, Christophe
Daumin, Camille
Hermida, Alexis
Booz, Thomas
Ghesquieres, Tristan
Crombet, Maxime
Martin, Nicolas
Huette, Pierre
Jounieaux, Vincent
Dupont, Hervé
Abou-Arab, Osama
Mahjoub, Yazine
author_sort Beyls, Christophe
collection PubMed
description Introduction: Right ventricular systolic dysfunction (RVsD) increases acute respiratory distress syndrome mortality in COVID-19 infection (CARDS). The RV longitudinal shortening fraction (RV-LSF) is an angle-independent and automatically calculated speckle-tracking parameter. We explored the association between RV-LSF and 30-day mortality in CARDS patients. Methods: Moderate-to-severe CARDS patients hospitalized at Amiens University Hospital with transesophageal echocardiography performed within 48 h of intensive care unit admission were included. RVsD was defined by an RV-LSF of <20%. The patients were divided into two groups according to the presence of RVsD. Using multivariate Cox regression, clinical and echocardiographic risk factors predicting 30-day mortality were evaluated. Results: Between 28 February 2020 and 1 December 2021, 86 patients were included. A total of 43% (n = 37/86) of the patients showed RVsD and 22% (n = 19/86) of the patients died. RV-LSF was observed in 26 (23.1–29.7)% of the no-RVsD function group and 16.5 (13.7–19.4)% (p < 0.001) of the RVsD group. Cardiogenic shock (n = 7/37 vs. 2/49, p = 0.03) and acute cor pulmonale (n = 18/37 vs. 10/49, p = 0.009) were more frequent in the RVsD group. The 30-day mortality was higher in the RVsD group (15/37 vs. 4/49, p = 0.001). In a multivariable Cox model, RV-LSF was an independent mortality factor (HR 4.45, 95%CI (1.43–13.8), p = 0.01). Conclusion: in a cohort of moderate-to-severe CARDS patients under mechanical ventilation, RVsD defined by the RV-LSF was associated with higher 30-day mortalities.
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spelling pubmed-91039752022-05-14 Association between the Right Ventricular Longitudinal Shortening Fraction and Mortality in Acute Respiratory Distress Syndrome Related to COVID-19 Infection: A Prospective Study Beyls, Christophe Daumin, Camille Hermida, Alexis Booz, Thomas Ghesquieres, Tristan Crombet, Maxime Martin, Nicolas Huette, Pierre Jounieaux, Vincent Dupont, Hervé Abou-Arab, Osama Mahjoub, Yazine J Clin Med Article Introduction: Right ventricular systolic dysfunction (RVsD) increases acute respiratory distress syndrome mortality in COVID-19 infection (CARDS). The RV longitudinal shortening fraction (RV-LSF) is an angle-independent and automatically calculated speckle-tracking parameter. We explored the association between RV-LSF and 30-day mortality in CARDS patients. Methods: Moderate-to-severe CARDS patients hospitalized at Amiens University Hospital with transesophageal echocardiography performed within 48 h of intensive care unit admission were included. RVsD was defined by an RV-LSF of <20%. The patients were divided into two groups according to the presence of RVsD. Using multivariate Cox regression, clinical and echocardiographic risk factors predicting 30-day mortality were evaluated. Results: Between 28 February 2020 and 1 December 2021, 86 patients were included. A total of 43% (n = 37/86) of the patients showed RVsD and 22% (n = 19/86) of the patients died. RV-LSF was observed in 26 (23.1–29.7)% of the no-RVsD function group and 16.5 (13.7–19.4)% (p < 0.001) of the RVsD group. Cardiogenic shock (n = 7/37 vs. 2/49, p = 0.03) and acute cor pulmonale (n = 18/37 vs. 10/49, p = 0.009) were more frequent in the RVsD group. The 30-day mortality was higher in the RVsD group (15/37 vs. 4/49, p = 0.001). In a multivariable Cox model, RV-LSF was an independent mortality factor (HR 4.45, 95%CI (1.43–13.8), p = 0.01). Conclusion: in a cohort of moderate-to-severe CARDS patients under mechanical ventilation, RVsD defined by the RV-LSF was associated with higher 30-day mortalities. MDPI 2022-05-06 /pmc/articles/PMC9103975/ /pubmed/35566751 http://dx.doi.org/10.3390/jcm11092625 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Beyls, Christophe
Daumin, Camille
Hermida, Alexis
Booz, Thomas
Ghesquieres, Tristan
Crombet, Maxime
Martin, Nicolas
Huette, Pierre
Jounieaux, Vincent
Dupont, Hervé
Abou-Arab, Osama
Mahjoub, Yazine
Association between the Right Ventricular Longitudinal Shortening Fraction and Mortality in Acute Respiratory Distress Syndrome Related to COVID-19 Infection: A Prospective Study
title Association between the Right Ventricular Longitudinal Shortening Fraction and Mortality in Acute Respiratory Distress Syndrome Related to COVID-19 Infection: A Prospective Study
title_full Association between the Right Ventricular Longitudinal Shortening Fraction and Mortality in Acute Respiratory Distress Syndrome Related to COVID-19 Infection: A Prospective Study
title_fullStr Association between the Right Ventricular Longitudinal Shortening Fraction and Mortality in Acute Respiratory Distress Syndrome Related to COVID-19 Infection: A Prospective Study
title_full_unstemmed Association between the Right Ventricular Longitudinal Shortening Fraction and Mortality in Acute Respiratory Distress Syndrome Related to COVID-19 Infection: A Prospective Study
title_short Association between the Right Ventricular Longitudinal Shortening Fraction and Mortality in Acute Respiratory Distress Syndrome Related to COVID-19 Infection: A Prospective Study
title_sort association between the right ventricular longitudinal shortening fraction and mortality in acute respiratory distress syndrome related to covid-19 infection: a prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103975/
https://www.ncbi.nlm.nih.gov/pubmed/35566751
http://dx.doi.org/10.3390/jcm11092625
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