Factors Regulating or Regulated by Myogenic Regulatory Factors in Skeletal Muscle Stem Cells

MyoD, Myf5, myogenin, and MRF4 (also known as Myf6 or herculin) are myogenic regulatory factors (MRFs). MRFs are regarded as master transcription factors that are upregulated during myogenesis and influence stem cells to differentiate into myogenic lineage cells. In this review, we summarize MRFs, t...

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Detalles Bibliográficos
Autores principales: Shirakawa, Tomohiko, Toyono, Takashi, Inoue, Asako, Matsubara, Takuma, Kawamoto, Tatsuo, Kokabu, Shoichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104119/
https://www.ncbi.nlm.nih.gov/pubmed/35563799
http://dx.doi.org/10.3390/cells11091493
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author Shirakawa, Tomohiko
Toyono, Takashi
Inoue, Asako
Matsubara, Takuma
Kawamoto, Tatsuo
Kokabu, Shoichiro
author_facet Shirakawa, Tomohiko
Toyono, Takashi
Inoue, Asako
Matsubara, Takuma
Kawamoto, Tatsuo
Kokabu, Shoichiro
author_sort Shirakawa, Tomohiko
collection PubMed
description MyoD, Myf5, myogenin, and MRF4 (also known as Myf6 or herculin) are myogenic regulatory factors (MRFs). MRFs are regarded as master transcription factors that are upregulated during myogenesis and influence stem cells to differentiate into myogenic lineage cells. In this review, we summarize MRFs, their regulatory factors, such as TLE3, NF-κB, and MRF target genes, including non-myogenic genes such as taste receptors. Understanding the function of MRFs and the physiology or pathology of satellite cells will contribute to the development of cell therapy and drug discovery for muscle-related diseases.
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spelling pubmed-91041192022-05-14 Factors Regulating or Regulated by Myogenic Regulatory Factors in Skeletal Muscle Stem Cells Shirakawa, Tomohiko Toyono, Takashi Inoue, Asako Matsubara, Takuma Kawamoto, Tatsuo Kokabu, Shoichiro Cells Review MyoD, Myf5, myogenin, and MRF4 (also known as Myf6 or herculin) are myogenic regulatory factors (MRFs). MRFs are regarded as master transcription factors that are upregulated during myogenesis and influence stem cells to differentiate into myogenic lineage cells. In this review, we summarize MRFs, their regulatory factors, such as TLE3, NF-κB, and MRF target genes, including non-myogenic genes such as taste receptors. Understanding the function of MRFs and the physiology or pathology of satellite cells will contribute to the development of cell therapy and drug discovery for muscle-related diseases. MDPI 2022-04-29 /pmc/articles/PMC9104119/ /pubmed/35563799 http://dx.doi.org/10.3390/cells11091493 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shirakawa, Tomohiko
Toyono, Takashi
Inoue, Asako
Matsubara, Takuma
Kawamoto, Tatsuo
Kokabu, Shoichiro
Factors Regulating or Regulated by Myogenic Regulatory Factors in Skeletal Muscle Stem Cells
title Factors Regulating or Regulated by Myogenic Regulatory Factors in Skeletal Muscle Stem Cells
title_full Factors Regulating or Regulated by Myogenic Regulatory Factors in Skeletal Muscle Stem Cells
title_fullStr Factors Regulating or Regulated by Myogenic Regulatory Factors in Skeletal Muscle Stem Cells
title_full_unstemmed Factors Regulating or Regulated by Myogenic Regulatory Factors in Skeletal Muscle Stem Cells
title_short Factors Regulating or Regulated by Myogenic Regulatory Factors in Skeletal Muscle Stem Cells
title_sort factors regulating or regulated by myogenic regulatory factors in skeletal muscle stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104119/
https://www.ncbi.nlm.nih.gov/pubmed/35563799
http://dx.doi.org/10.3390/cells11091493
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