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Epidemiology, Clinical Presentation and Treatment of Non-Hepatic Hyperammonemia in ICU COVID-19 Patients
(1) Background: Although COVID-19 is largely a respiratory disease, it is actually a systemic disease that has a wide range of effects that are not yet fully known. The aim of this study was to determine the incidence, predictors and outcome of non-hepatic hyperammonemia (NHH) in COVID-19 in intensi...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104133/ https://www.ncbi.nlm.nih.gov/pubmed/35566715 http://dx.doi.org/10.3390/jcm11092592 |
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author | Tetaj, Nardi Stazi, Giulia Valeria Marini, Maria Cristina Garotto, Gabriele Busso, Donatella Scarcia, Silvana Caravella, Ilaria Macchione, Manuela De Angelis, Giada Di Lorenzo, Rachele Carucci, Alessandro Capone, Alessandro Antinori, Andrea Palmieri, Fabrizio D’Offizi, Gianpiero Taglietti, Fabrizio Ianniello, Stefania Campioni, Paolo Vaia, Francesco Nicastri, Emanuele Girardi, Enrico Marchioni, Luisa |
author_facet | Tetaj, Nardi Stazi, Giulia Valeria Marini, Maria Cristina Garotto, Gabriele Busso, Donatella Scarcia, Silvana Caravella, Ilaria Macchione, Manuela De Angelis, Giada Di Lorenzo, Rachele Carucci, Alessandro Capone, Alessandro Antinori, Andrea Palmieri, Fabrizio D’Offizi, Gianpiero Taglietti, Fabrizio Ianniello, Stefania Campioni, Paolo Vaia, Francesco Nicastri, Emanuele Girardi, Enrico Marchioni, Luisa |
author_sort | Tetaj, Nardi |
collection | PubMed |
description | (1) Background: Although COVID-19 is largely a respiratory disease, it is actually a systemic disease that has a wide range of effects that are not yet fully known. The aim of this study was to determine the incidence, predictors and outcome of non-hepatic hyperammonemia (NHH) in COVID-19 in intensive care unit (ICU); (2) Methods: This is a 3-month prospective observational study in a third-level COVID-19 hospital. The authors collected demographic, clinical, severity score and outcome data. Logistic regression analyses were performed to identify predictors of NHH; (3) Results: 156 COVID-19 patients were admitted to the ICU. The incidence of NHH was 12.2% (19 patients). The univariate analysis showed that invasive mechanical ventilation had a 6.6-fold higher risk (OR 6.66, 95% CI 0.86–51.6, p = 0.039) for NHH, while in the multiple regression analysis, there was a 7-fold higher risk for NHH—but it was not statistically significant (OR 7.1, 95% CI 0.90–56.4, p = 0.062). Demographics, clinical characteristics and mortality in the ICU at 28 days did not show a significant association with NHH. (4) Conclusions: The incidence of NHH in ICU COVID-19 patients was not low. NHH did not appear to significantly increase mortality, and all patients with non-hepatic hyperammonemia were successfully treated without further complications. However, the pathogenesis of NHH in ICU patients with COVID-19 remains a topic to be explored with further research. |
format | Online Article Text |
id | pubmed-9104133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91041332022-05-14 Epidemiology, Clinical Presentation and Treatment of Non-Hepatic Hyperammonemia in ICU COVID-19 Patients Tetaj, Nardi Stazi, Giulia Valeria Marini, Maria Cristina Garotto, Gabriele Busso, Donatella Scarcia, Silvana Caravella, Ilaria Macchione, Manuela De Angelis, Giada Di Lorenzo, Rachele Carucci, Alessandro Capone, Alessandro Antinori, Andrea Palmieri, Fabrizio D’Offizi, Gianpiero Taglietti, Fabrizio Ianniello, Stefania Campioni, Paolo Vaia, Francesco Nicastri, Emanuele Girardi, Enrico Marchioni, Luisa J Clin Med Article (1) Background: Although COVID-19 is largely a respiratory disease, it is actually a systemic disease that has a wide range of effects that are not yet fully known. The aim of this study was to determine the incidence, predictors and outcome of non-hepatic hyperammonemia (NHH) in COVID-19 in intensive care unit (ICU); (2) Methods: This is a 3-month prospective observational study in a third-level COVID-19 hospital. The authors collected demographic, clinical, severity score and outcome data. Logistic regression analyses were performed to identify predictors of NHH; (3) Results: 156 COVID-19 patients were admitted to the ICU. The incidence of NHH was 12.2% (19 patients). The univariate analysis showed that invasive mechanical ventilation had a 6.6-fold higher risk (OR 6.66, 95% CI 0.86–51.6, p = 0.039) for NHH, while in the multiple regression analysis, there was a 7-fold higher risk for NHH—but it was not statistically significant (OR 7.1, 95% CI 0.90–56.4, p = 0.062). Demographics, clinical characteristics and mortality in the ICU at 28 days did not show a significant association with NHH. (4) Conclusions: The incidence of NHH in ICU COVID-19 patients was not low. NHH did not appear to significantly increase mortality, and all patients with non-hepatic hyperammonemia were successfully treated without further complications. However, the pathogenesis of NHH in ICU patients with COVID-19 remains a topic to be explored with further research. MDPI 2022-05-05 /pmc/articles/PMC9104133/ /pubmed/35566715 http://dx.doi.org/10.3390/jcm11092592 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tetaj, Nardi Stazi, Giulia Valeria Marini, Maria Cristina Garotto, Gabriele Busso, Donatella Scarcia, Silvana Caravella, Ilaria Macchione, Manuela De Angelis, Giada Di Lorenzo, Rachele Carucci, Alessandro Capone, Alessandro Antinori, Andrea Palmieri, Fabrizio D’Offizi, Gianpiero Taglietti, Fabrizio Ianniello, Stefania Campioni, Paolo Vaia, Francesco Nicastri, Emanuele Girardi, Enrico Marchioni, Luisa Epidemiology, Clinical Presentation and Treatment of Non-Hepatic Hyperammonemia in ICU COVID-19 Patients |
title | Epidemiology, Clinical Presentation and Treatment of Non-Hepatic Hyperammonemia in ICU COVID-19 Patients |
title_full | Epidemiology, Clinical Presentation and Treatment of Non-Hepatic Hyperammonemia in ICU COVID-19 Patients |
title_fullStr | Epidemiology, Clinical Presentation and Treatment of Non-Hepatic Hyperammonemia in ICU COVID-19 Patients |
title_full_unstemmed | Epidemiology, Clinical Presentation and Treatment of Non-Hepatic Hyperammonemia in ICU COVID-19 Patients |
title_short | Epidemiology, Clinical Presentation and Treatment of Non-Hepatic Hyperammonemia in ICU COVID-19 Patients |
title_sort | epidemiology, clinical presentation and treatment of non-hepatic hyperammonemia in icu covid-19 patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104133/ https://www.ncbi.nlm.nih.gov/pubmed/35566715 http://dx.doi.org/10.3390/jcm11092592 |
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