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Platelet Versus Megakaryocyte: Who Is the Real Bandleader of Thromboinflammation in Sepsis?
Platelets are mainly known for their key role in hemostasis and thrombosis. However, studies over the last two decades have shown their strong implication in mechanisms associated with inflammation, thrombosis, and the immune system in various neoplastic, inflammatory, autoimmune, and infectious dis...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104300/ https://www.ncbi.nlm.nih.gov/pubmed/35563812 http://dx.doi.org/10.3390/cells11091507 |
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author | Garcia, Cédric Compagnon, Baptiste Poëtte, Michaël Gratacap, Marie-Pierre Lapébie, François-Xavier Voisin, Sophie Minville, Vincent Payrastre, Bernard Vardon-Bounes, Fanny Ribes, Agnès |
author_facet | Garcia, Cédric Compagnon, Baptiste Poëtte, Michaël Gratacap, Marie-Pierre Lapébie, François-Xavier Voisin, Sophie Minville, Vincent Payrastre, Bernard Vardon-Bounes, Fanny Ribes, Agnès |
author_sort | Garcia, Cédric |
collection | PubMed |
description | Platelets are mainly known for their key role in hemostasis and thrombosis. However, studies over the last two decades have shown their strong implication in mechanisms associated with inflammation, thrombosis, and the immune system in various neoplastic, inflammatory, autoimmune, and infectious diseases. During sepsis, platelets amplify the recruitment and activation of innate immune cells at the site of infection and contribute to the elimination of pathogens. In certain conditions, these mechanisms can lead to thromboinflammation resulting in severe organ dysfunction. Here, we discuss the interactions of platelets with leukocytes, neutrophil extracellular traps (NETs), and endothelial cells during sepsis. The intrinsic properties of platelets that generate an inflammatory signal through the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome are discussed. As an example of immunothrombosis, the implication of platelets in vaccine-induced immune thrombotic thrombocytopenia is documented. Finally, we discuss the role of megakaryocytes (MKs) in thromboinflammation and their adaptive responses. |
format | Online Article Text |
id | pubmed-9104300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91043002022-05-14 Platelet Versus Megakaryocyte: Who Is the Real Bandleader of Thromboinflammation in Sepsis? Garcia, Cédric Compagnon, Baptiste Poëtte, Michaël Gratacap, Marie-Pierre Lapébie, François-Xavier Voisin, Sophie Minville, Vincent Payrastre, Bernard Vardon-Bounes, Fanny Ribes, Agnès Cells Review Platelets are mainly known for their key role in hemostasis and thrombosis. However, studies over the last two decades have shown their strong implication in mechanisms associated with inflammation, thrombosis, and the immune system in various neoplastic, inflammatory, autoimmune, and infectious diseases. During sepsis, platelets amplify the recruitment and activation of innate immune cells at the site of infection and contribute to the elimination of pathogens. In certain conditions, these mechanisms can lead to thromboinflammation resulting in severe organ dysfunction. Here, we discuss the interactions of platelets with leukocytes, neutrophil extracellular traps (NETs), and endothelial cells during sepsis. The intrinsic properties of platelets that generate an inflammatory signal through the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome are discussed. As an example of immunothrombosis, the implication of platelets in vaccine-induced immune thrombotic thrombocytopenia is documented. Finally, we discuss the role of megakaryocytes (MKs) in thromboinflammation and their adaptive responses. MDPI 2022-04-30 /pmc/articles/PMC9104300/ /pubmed/35563812 http://dx.doi.org/10.3390/cells11091507 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Garcia, Cédric Compagnon, Baptiste Poëtte, Michaël Gratacap, Marie-Pierre Lapébie, François-Xavier Voisin, Sophie Minville, Vincent Payrastre, Bernard Vardon-Bounes, Fanny Ribes, Agnès Platelet Versus Megakaryocyte: Who Is the Real Bandleader of Thromboinflammation in Sepsis? |
title | Platelet Versus Megakaryocyte: Who Is the Real Bandleader of Thromboinflammation in Sepsis? |
title_full | Platelet Versus Megakaryocyte: Who Is the Real Bandleader of Thromboinflammation in Sepsis? |
title_fullStr | Platelet Versus Megakaryocyte: Who Is the Real Bandleader of Thromboinflammation in Sepsis? |
title_full_unstemmed | Platelet Versus Megakaryocyte: Who Is the Real Bandleader of Thromboinflammation in Sepsis? |
title_short | Platelet Versus Megakaryocyte: Who Is the Real Bandleader of Thromboinflammation in Sepsis? |
title_sort | platelet versus megakaryocyte: who is the real bandleader of thromboinflammation in sepsis? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104300/ https://www.ncbi.nlm.nih.gov/pubmed/35563812 http://dx.doi.org/10.3390/cells11091507 |
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