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Platelet Versus Megakaryocyte: Who Is the Real Bandleader of Thromboinflammation in Sepsis?

Platelets are mainly known for their key role in hemostasis and thrombosis. However, studies over the last two decades have shown their strong implication in mechanisms associated with inflammation, thrombosis, and the immune system in various neoplastic, inflammatory, autoimmune, and infectious dis...

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Autores principales: Garcia, Cédric, Compagnon, Baptiste, Poëtte, Michaël, Gratacap, Marie-Pierre, Lapébie, François-Xavier, Voisin, Sophie, Minville, Vincent, Payrastre, Bernard, Vardon-Bounes, Fanny, Ribes, Agnès
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104300/
https://www.ncbi.nlm.nih.gov/pubmed/35563812
http://dx.doi.org/10.3390/cells11091507
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author Garcia, Cédric
Compagnon, Baptiste
Poëtte, Michaël
Gratacap, Marie-Pierre
Lapébie, François-Xavier
Voisin, Sophie
Minville, Vincent
Payrastre, Bernard
Vardon-Bounes, Fanny
Ribes, Agnès
author_facet Garcia, Cédric
Compagnon, Baptiste
Poëtte, Michaël
Gratacap, Marie-Pierre
Lapébie, François-Xavier
Voisin, Sophie
Minville, Vincent
Payrastre, Bernard
Vardon-Bounes, Fanny
Ribes, Agnès
author_sort Garcia, Cédric
collection PubMed
description Platelets are mainly known for their key role in hemostasis and thrombosis. However, studies over the last two decades have shown their strong implication in mechanisms associated with inflammation, thrombosis, and the immune system in various neoplastic, inflammatory, autoimmune, and infectious diseases. During sepsis, platelets amplify the recruitment and activation of innate immune cells at the site of infection and contribute to the elimination of pathogens. In certain conditions, these mechanisms can lead to thromboinflammation resulting in severe organ dysfunction. Here, we discuss the interactions of platelets with leukocytes, neutrophil extracellular traps (NETs), and endothelial cells during sepsis. The intrinsic properties of platelets that generate an inflammatory signal through the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome are discussed. As an example of immunothrombosis, the implication of platelets in vaccine-induced immune thrombotic thrombocytopenia is documented. Finally, we discuss the role of megakaryocytes (MKs) in thromboinflammation and their adaptive responses.
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spelling pubmed-91043002022-05-14 Platelet Versus Megakaryocyte: Who Is the Real Bandleader of Thromboinflammation in Sepsis? Garcia, Cédric Compagnon, Baptiste Poëtte, Michaël Gratacap, Marie-Pierre Lapébie, François-Xavier Voisin, Sophie Minville, Vincent Payrastre, Bernard Vardon-Bounes, Fanny Ribes, Agnès Cells Review Platelets are mainly known for their key role in hemostasis and thrombosis. However, studies over the last two decades have shown their strong implication in mechanisms associated with inflammation, thrombosis, and the immune system in various neoplastic, inflammatory, autoimmune, and infectious diseases. During sepsis, platelets amplify the recruitment and activation of innate immune cells at the site of infection and contribute to the elimination of pathogens. In certain conditions, these mechanisms can lead to thromboinflammation resulting in severe organ dysfunction. Here, we discuss the interactions of platelets with leukocytes, neutrophil extracellular traps (NETs), and endothelial cells during sepsis. The intrinsic properties of platelets that generate an inflammatory signal through the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome are discussed. As an example of immunothrombosis, the implication of platelets in vaccine-induced immune thrombotic thrombocytopenia is documented. Finally, we discuss the role of megakaryocytes (MKs) in thromboinflammation and their adaptive responses. MDPI 2022-04-30 /pmc/articles/PMC9104300/ /pubmed/35563812 http://dx.doi.org/10.3390/cells11091507 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Garcia, Cédric
Compagnon, Baptiste
Poëtte, Michaël
Gratacap, Marie-Pierre
Lapébie, François-Xavier
Voisin, Sophie
Minville, Vincent
Payrastre, Bernard
Vardon-Bounes, Fanny
Ribes, Agnès
Platelet Versus Megakaryocyte: Who Is the Real Bandleader of Thromboinflammation in Sepsis?
title Platelet Versus Megakaryocyte: Who Is the Real Bandleader of Thromboinflammation in Sepsis?
title_full Platelet Versus Megakaryocyte: Who Is the Real Bandleader of Thromboinflammation in Sepsis?
title_fullStr Platelet Versus Megakaryocyte: Who Is the Real Bandleader of Thromboinflammation in Sepsis?
title_full_unstemmed Platelet Versus Megakaryocyte: Who Is the Real Bandleader of Thromboinflammation in Sepsis?
title_short Platelet Versus Megakaryocyte: Who Is the Real Bandleader of Thromboinflammation in Sepsis?
title_sort platelet versus megakaryocyte: who is the real bandleader of thromboinflammation in sepsis?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104300/
https://www.ncbi.nlm.nih.gov/pubmed/35563812
http://dx.doi.org/10.3390/cells11091507
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