Cargando…
Formulation of Chlorine-Dioxide-Releasing Nanofibers for Disinfection in Humid and CO(2)-Rich Environment
Background: Preventing infectious diseases has become particularly relevant in the past few years. Therefore, antiseptics that are harmless and insusceptible to microbial resistance mechanisms are desired in medicine and public health. In our recent work, a poly(ethylene oxide)-based nanofibrous mat...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104377/ https://www.ncbi.nlm.nih.gov/pubmed/35564190 http://dx.doi.org/10.3390/nano12091481 |
_version_ | 1784707779769925632 |
---|---|
author | Palcsó, Barnabás Kazsoki, Adrienn Herczegh, Anna Ghidán, Ágoston Pinke, Balázs Mészáros, László Zelkó, Romána |
author_facet | Palcsó, Barnabás Kazsoki, Adrienn Herczegh, Anna Ghidán, Ágoston Pinke, Balázs Mészáros, László Zelkó, Romána |
author_sort | Palcsó, Barnabás |
collection | PubMed |
description | Background: Preventing infectious diseases has become particularly relevant in the past few years. Therefore, antiseptics that are harmless and insusceptible to microbial resistance mechanisms are desired in medicine and public health. In our recent work, a poly(ethylene oxide)-based nanofibrous mat loaded with sodium chlorite was formulated. Methods: We tested the chlorine dioxide production and bacterial inactivation of the fibers in a medium, modeling the parameters of human exhaled air (ca. 5% (v/v) CO(2), T = 37 °C, RH > 95%). The morphology and microstructure of the fibers were investigated via scanning electron microscopy and infrared spectroscopy. Results: Smooth-surfaced, nanoscale fibers were produced. The ClO(2)-producing ability of the fibers decreased from 65.8 ppm/mg to 4.8 ppm/mg with the increase of the sample weight from 1 to 30 mg. The effect of CO(2) concentration and exposure time was also evaluated. The antibacterial activity of the fibers was tested in a 24 h experiment. The sodium-chlorite-loaded fibers showed substantial antibacterial activity. Conclusions: Chlorine dioxide was liberated into the gas phase in the presence of CO(2) and water vapor, eliminating the bacteria. Sodium-chlorite-loaded nanofibers can be sources of prolonged chlorine dioxide production and subsequent pathogen inactivation in a CO(2)-rich and humid environment. Based on the results, further evaluation of the possible application of the formulation in face-mask filters as medical devices is encouraged. |
format | Online Article Text |
id | pubmed-9104377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91043772022-05-14 Formulation of Chlorine-Dioxide-Releasing Nanofibers for Disinfection in Humid and CO(2)-Rich Environment Palcsó, Barnabás Kazsoki, Adrienn Herczegh, Anna Ghidán, Ágoston Pinke, Balázs Mészáros, László Zelkó, Romána Nanomaterials (Basel) Article Background: Preventing infectious diseases has become particularly relevant in the past few years. Therefore, antiseptics that are harmless and insusceptible to microbial resistance mechanisms are desired in medicine and public health. In our recent work, a poly(ethylene oxide)-based nanofibrous mat loaded with sodium chlorite was formulated. Methods: We tested the chlorine dioxide production and bacterial inactivation of the fibers in a medium, modeling the parameters of human exhaled air (ca. 5% (v/v) CO(2), T = 37 °C, RH > 95%). The morphology and microstructure of the fibers were investigated via scanning electron microscopy and infrared spectroscopy. Results: Smooth-surfaced, nanoscale fibers were produced. The ClO(2)-producing ability of the fibers decreased from 65.8 ppm/mg to 4.8 ppm/mg with the increase of the sample weight from 1 to 30 mg. The effect of CO(2) concentration and exposure time was also evaluated. The antibacterial activity of the fibers was tested in a 24 h experiment. The sodium-chlorite-loaded fibers showed substantial antibacterial activity. Conclusions: Chlorine dioxide was liberated into the gas phase in the presence of CO(2) and water vapor, eliminating the bacteria. Sodium-chlorite-loaded nanofibers can be sources of prolonged chlorine dioxide production and subsequent pathogen inactivation in a CO(2)-rich and humid environment. Based on the results, further evaluation of the possible application of the formulation in face-mask filters as medical devices is encouraged. MDPI 2022-04-27 /pmc/articles/PMC9104377/ /pubmed/35564190 http://dx.doi.org/10.3390/nano12091481 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Palcsó, Barnabás Kazsoki, Adrienn Herczegh, Anna Ghidán, Ágoston Pinke, Balázs Mészáros, László Zelkó, Romána Formulation of Chlorine-Dioxide-Releasing Nanofibers for Disinfection in Humid and CO(2)-Rich Environment |
title | Formulation of Chlorine-Dioxide-Releasing Nanofibers for Disinfection in Humid and CO(2)-Rich Environment |
title_full | Formulation of Chlorine-Dioxide-Releasing Nanofibers for Disinfection in Humid and CO(2)-Rich Environment |
title_fullStr | Formulation of Chlorine-Dioxide-Releasing Nanofibers for Disinfection in Humid and CO(2)-Rich Environment |
title_full_unstemmed | Formulation of Chlorine-Dioxide-Releasing Nanofibers for Disinfection in Humid and CO(2)-Rich Environment |
title_short | Formulation of Chlorine-Dioxide-Releasing Nanofibers for Disinfection in Humid and CO(2)-Rich Environment |
title_sort | formulation of chlorine-dioxide-releasing nanofibers for disinfection in humid and co(2)-rich environment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104377/ https://www.ncbi.nlm.nih.gov/pubmed/35564190 http://dx.doi.org/10.3390/nano12091481 |
work_keys_str_mv | AT palcsobarnabas formulationofchlorinedioxidereleasingnanofibersfordisinfectioninhumidandco2richenvironment AT kazsokiadrienn formulationofchlorinedioxidereleasingnanofibersfordisinfectioninhumidandco2richenvironment AT herczeghanna formulationofchlorinedioxidereleasingnanofibersfordisinfectioninhumidandco2richenvironment AT ghidanagoston formulationofchlorinedioxidereleasingnanofibersfordisinfectioninhumidandco2richenvironment AT pinkebalazs formulationofchlorinedioxidereleasingnanofibersfordisinfectioninhumidandco2richenvironment AT meszaroslaszlo formulationofchlorinedioxidereleasingnanofibersfordisinfectioninhumidandco2richenvironment AT zelkoromana formulationofchlorinedioxidereleasingnanofibersfordisinfectioninhumidandco2richenvironment |