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Malignant Superficial Mesenchymal Tumors in Children

SIMPLE SUMMARY: Malignant tumors of the skin and subcutaneous tissue are rare in children. Most of these cancers are mesenchymal tumors and among these tumors, most have an intermediate malignant potential or are considered low grade sarcomas. In addition, some sarcomas of deep soft tissues may also...

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Autores principales: Drabent, Philippe, Fraitag, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104419/
https://www.ncbi.nlm.nih.gov/pubmed/35565289
http://dx.doi.org/10.3390/cancers14092160
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author Drabent, Philippe
Fraitag, Sylvie
author_facet Drabent, Philippe
Fraitag, Sylvie
author_sort Drabent, Philippe
collection PubMed
description SIMPLE SUMMARY: Malignant tumors of the skin and subcutaneous tissue are rare in children. Most of these cancers are mesenchymal tumors and among these tumors, most have an intermediate malignant potential or are considered low grade sarcomas. In addition, some sarcomas of deep soft tissues may also involve the skin by contiguity. This review aims to sort out the diversity of these malignant mesenchymal tumors in children, with a particular focus on clinical features that may be useful for clinicians (especially age at presentation) and on the newest entities and genetic data. ABSTRACT: Malignant superficial mesenchymal tumors are a very diverse group of neoplasms with few clinical and radiological discriminatory factors. Hence, some of these cancers are rarely suspected based on clinical and radiological grounds, others may be easily misdiagnosed, and the histological analysis of a biopsy or resection is central in the diagnostic process. In children, the age at presentation is a major element of the differential diagnosis. Some tumors have a very distinct epidemiology, while others may be seen at any age. More recently, the advances in molecular biology have greatly improved the diagnosis of mesenchymal tumors and new entities are still being described. In the present review, we provide an overview of the diversity of malignant superficial mesenchymal tumors in children, including new and/or rare entities. We discuss the important diagnostic features, be they clinical, histological, or molecular. Special attention was given to the genetic features of these tumors, particularly when they were helpful for the diagnosis or treatment.
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spelling pubmed-91044192022-05-14 Malignant Superficial Mesenchymal Tumors in Children Drabent, Philippe Fraitag, Sylvie Cancers (Basel) Review SIMPLE SUMMARY: Malignant tumors of the skin and subcutaneous tissue are rare in children. Most of these cancers are mesenchymal tumors and among these tumors, most have an intermediate malignant potential or are considered low grade sarcomas. In addition, some sarcomas of deep soft tissues may also involve the skin by contiguity. This review aims to sort out the diversity of these malignant mesenchymal tumors in children, with a particular focus on clinical features that may be useful for clinicians (especially age at presentation) and on the newest entities and genetic data. ABSTRACT: Malignant superficial mesenchymal tumors are a very diverse group of neoplasms with few clinical and radiological discriminatory factors. Hence, some of these cancers are rarely suspected based on clinical and radiological grounds, others may be easily misdiagnosed, and the histological analysis of a biopsy or resection is central in the diagnostic process. In children, the age at presentation is a major element of the differential diagnosis. Some tumors have a very distinct epidemiology, while others may be seen at any age. More recently, the advances in molecular biology have greatly improved the diagnosis of mesenchymal tumors and new entities are still being described. In the present review, we provide an overview of the diversity of malignant superficial mesenchymal tumors in children, including new and/or rare entities. We discuss the important diagnostic features, be they clinical, histological, or molecular. Special attention was given to the genetic features of these tumors, particularly when they were helpful for the diagnosis or treatment. MDPI 2022-04-26 /pmc/articles/PMC9104419/ /pubmed/35565289 http://dx.doi.org/10.3390/cancers14092160 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Drabent, Philippe
Fraitag, Sylvie
Malignant Superficial Mesenchymal Tumors in Children
title Malignant Superficial Mesenchymal Tumors in Children
title_full Malignant Superficial Mesenchymal Tumors in Children
title_fullStr Malignant Superficial Mesenchymal Tumors in Children
title_full_unstemmed Malignant Superficial Mesenchymal Tumors in Children
title_short Malignant Superficial Mesenchymal Tumors in Children
title_sort malignant superficial mesenchymal tumors in children
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104419/
https://www.ncbi.nlm.nih.gov/pubmed/35565289
http://dx.doi.org/10.3390/cancers14092160
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