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Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon

This study was carried out to investigate the frequency of genetic variants related to body mass index (BMI) and type 2 diabetes (T2D) and evaluating the potential impact of risk alleles on susceptibility to these disorders in six indigenous peoples from Brazilian Amazon region. The majority of Fst...

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Detalles Bibliográficos
Autores principales: Diniz, Isabela Guerreiro, Noce, Rosilene Reis Della, Pereira, Ana Paula, da Silva, Aylla Núbia Lima Martins, Sacuena, Eliene Rodrigues Putira, Lemes, Renan Barbosa, Cardoso-Costa, Greice de Lemos, Araújo, Gilderlânio Santana, Machado, Jéssica Lígia Picanço, Figueiredo, Fernanda Andreza de Pinho Lott, Hümemeier, Tábita, Guerreiro, João Farias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104643/
https://www.ncbi.nlm.nih.gov/pubmed/35560161
http://dx.doi.org/10.1590/1678-4685-GMB-2021-0153
Descripción
Sumario:This study was carried out to investigate the frequency of genetic variants related to body mass index (BMI) and type 2 diabetes (T2D) and evaluating the potential impact of risk alleles on susceptibility to these disorders in six indigenous peoples from Brazilian Amazon region. The majority of Fst values for pairwise population comparisons among the indigenous groups are low or moderate. The indigenous people show high values of differentiation with Africans, Europeans and Southeast Asians and moderate values with East Asian and American populations, as expected. The allelic frequencies among indigenous indicate that the majority of associations observed with T2D in continental populations can be replicated in native Amazonians. The genetic risk scores calculated for T2D in indigenous are high and similar to those calculated for Americans and East Asians, while the estimates obtained for obesity are low, probably due to the low frequencies of the risk allele of the FTO gene found in our samples. ADRB3-rs4994 and ABCC8-rs1799854 genes showed a significant association with BMI and waist circumference, and the KCNJ11-rs5219 gene with hyperglycemia. These results emphasize the importance of knowing the genetic variability underlying complex genetic diseases in indigenous peoples and the search for particular or rare variants.