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Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon
This study was carried out to investigate the frequency of genetic variants related to body mass index (BMI) and type 2 diabetes (T2D) and evaluating the potential impact of risk alleles on susceptibility to these disorders in six indigenous peoples from Brazilian Amazon region. The majority of Fst...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Genética
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104643/ https://www.ncbi.nlm.nih.gov/pubmed/35560161 http://dx.doi.org/10.1590/1678-4685-GMB-2021-0153 |
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author | Diniz, Isabela Guerreiro Noce, Rosilene Reis Della Pereira, Ana Paula da Silva, Aylla Núbia Lima Martins Sacuena, Eliene Rodrigues Putira Lemes, Renan Barbosa Cardoso-Costa, Greice de Lemos Araújo, Gilderlânio Santana Machado, Jéssica Lígia Picanço Figueiredo, Fernanda Andreza de Pinho Lott Hümemeier, Tábita Guerreiro, João Farias |
author_facet | Diniz, Isabela Guerreiro Noce, Rosilene Reis Della Pereira, Ana Paula da Silva, Aylla Núbia Lima Martins Sacuena, Eliene Rodrigues Putira Lemes, Renan Barbosa Cardoso-Costa, Greice de Lemos Araújo, Gilderlânio Santana Machado, Jéssica Lígia Picanço Figueiredo, Fernanda Andreza de Pinho Lott Hümemeier, Tábita Guerreiro, João Farias |
author_sort | Diniz, Isabela Guerreiro |
collection | PubMed |
description | This study was carried out to investigate the frequency of genetic variants related to body mass index (BMI) and type 2 diabetes (T2D) and evaluating the potential impact of risk alleles on susceptibility to these disorders in six indigenous peoples from Brazilian Amazon region. The majority of Fst values for pairwise population comparisons among the indigenous groups are low or moderate. The indigenous people show high values of differentiation with Africans, Europeans and Southeast Asians and moderate values with East Asian and American populations, as expected. The allelic frequencies among indigenous indicate that the majority of associations observed with T2D in continental populations can be replicated in native Amazonians. The genetic risk scores calculated for T2D in indigenous are high and similar to those calculated for Americans and East Asians, while the estimates obtained for obesity are low, probably due to the low frequencies of the risk allele of the FTO gene found in our samples. ADRB3-rs4994 and ABCC8-rs1799854 genes showed a significant association with BMI and waist circumference, and the KCNJ11-rs5219 gene with hyperglycemia. These results emphasize the importance of knowing the genetic variability underlying complex genetic diseases in indigenous peoples and the search for particular or rare variants. |
format | Online Article Text |
id | pubmed-9104643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Sociedade Brasileira de Genética |
record_format | MEDLINE/PubMed |
spelling | pubmed-91046432022-05-25 Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon Diniz, Isabela Guerreiro Noce, Rosilene Reis Della Pereira, Ana Paula da Silva, Aylla Núbia Lima Martins Sacuena, Eliene Rodrigues Putira Lemes, Renan Barbosa Cardoso-Costa, Greice de Lemos Araújo, Gilderlânio Santana Machado, Jéssica Lígia Picanço Figueiredo, Fernanda Andreza de Pinho Lott Hümemeier, Tábita Guerreiro, João Farias Genet Mol Biol Human and Medical Genetics This study was carried out to investigate the frequency of genetic variants related to body mass index (BMI) and type 2 diabetes (T2D) and evaluating the potential impact of risk alleles on susceptibility to these disorders in six indigenous peoples from Brazilian Amazon region. The majority of Fst values for pairwise population comparisons among the indigenous groups are low or moderate. The indigenous people show high values of differentiation with Africans, Europeans and Southeast Asians and moderate values with East Asian and American populations, as expected. The allelic frequencies among indigenous indicate that the majority of associations observed with T2D in continental populations can be replicated in native Amazonians. The genetic risk scores calculated for T2D in indigenous are high and similar to those calculated for Americans and East Asians, while the estimates obtained for obesity are low, probably due to the low frequencies of the risk allele of the FTO gene found in our samples. ADRB3-rs4994 and ABCC8-rs1799854 genes showed a significant association with BMI and waist circumference, and the KCNJ11-rs5219 gene with hyperglycemia. These results emphasize the importance of knowing the genetic variability underlying complex genetic diseases in indigenous peoples and the search for particular or rare variants. Sociedade Brasileira de Genética 2022-05-11 /pmc/articles/PMC9104643/ /pubmed/35560161 http://dx.doi.org/10.1590/1678-4685-GMB-2021-0153 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Human and Medical Genetics Diniz, Isabela Guerreiro Noce, Rosilene Reis Della Pereira, Ana Paula da Silva, Aylla Núbia Lima Martins Sacuena, Eliene Rodrigues Putira Lemes, Renan Barbosa Cardoso-Costa, Greice de Lemos Araújo, Gilderlânio Santana Machado, Jéssica Lígia Picanço Figueiredo, Fernanda Andreza de Pinho Lott Hümemeier, Tábita Guerreiro, João Farias Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon |
title | Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon |
title_full | Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon |
title_fullStr | Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon |
title_full_unstemmed | Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon |
title_short | Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon |
title_sort | common bmi and diabetes-related genetic variants: a pilot study among indigenous people in the brazilian amazon |
topic | Human and Medical Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104643/ https://www.ncbi.nlm.nih.gov/pubmed/35560161 http://dx.doi.org/10.1590/1678-4685-GMB-2021-0153 |
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