Early embryonic mutations reveal dynamics of somatic and germ cell lineages in mice

De novo mutations accumulate with zygotic cell divisions. However, the occurrence of these mutations and the way they are inherited by somatic cells and germ cells remain unclear. Here, we present a novel method to reconstruct cell lineages. We identified mosaic mutations in mice using deep whole-ge...

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Detalles Bibliográficos
Autores principales: Uchimura, Arikuni, Matsumoto, Hirotaka, Satoh, Yasunari, Minakuchi, Yohei, Wakayama, Sayaka, Wakayama, Teruhiko, Higuchi, Mayumi, Hashimoto, Masakazu, Fukumura, Ryutaro, Toyoda, Atsushi, Gondo, Yoichi, Yagi, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104692/
https://www.ncbi.nlm.nih.gov/pubmed/35534232
http://dx.doi.org/10.1101/gr.276363.121

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