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A general framework for identifying oligogenic combinations of rare variants in complex disorders
Genetic studies of complex disorders such as autism and intellectual disability (ID) are often based on enrichment of individual rare variants or their aggregate burden in affected individuals compared to controls. However, these studies overlook the influence of combinations of rare variants that m...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104696/ https://www.ncbi.nlm.nih.gov/pubmed/35301265 http://dx.doi.org/10.1101/gr.276348.121 |