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P-glycoprotein Mediates Resistance to the Anaplastic Lymphoma Kinase Inhiitor Ensartinib in Cancer Cells

SIMPLE SUMMARY: P-glycoprotein (P-gp; ABCB1) is the most well-characterized ATP-binding cassette (ABC) multidrug efflux transporter known to actively transport a wide variety of cytotoxic and molecularly targeted drugs out of cancer cells, causing multidrug resistance (MDR) and poor prognosis in can...

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Detalles Bibliográficos
Autores principales:	Wu, Chung-Pu, Hung, Cheng-Yu, Murakami, Megumi, Wu, Yu-Shan, Lin, Chun-Ling, Huang, Yang-Hui, Hung, Tai-Ho, Yu, Jau-Song, Ambudkar, Suresh V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104801/ https://www.ncbi.nlm.nih.gov/pubmed/35565470 http://dx.doi.org/10.3390/cancers14092341

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