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Is Infantile Hemangioma a Neuroendocrine Tumor?
Infantile hemangioma (IH) is the most common infantile tumor, affecting 5–10% of newborns. Propranolol, a nonselective β-adrenergic receptor (ADRB) antagonist, is currently the first-line treatment for severe IH; however, both its mechanism of action and its main cellular target remain poorly unders...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104933/ https://www.ncbi.nlm.nih.gov/pubmed/35563552 http://dx.doi.org/10.3390/ijms23095140 |
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author | Kaulanjan-Checkmodine, Priscilla Oucherif, Sandra Prey, Sorilla Gontier, Etienne Lacomme, Sabrina Loot, Maya Miljkovic-Licina, Marijana Cario, Muriel Léauté-Labrèze, Christine Taieb, Alain Moisan, François Rezvani, Hamid Reza |
author_facet | Kaulanjan-Checkmodine, Priscilla Oucherif, Sandra Prey, Sorilla Gontier, Etienne Lacomme, Sabrina Loot, Maya Miljkovic-Licina, Marijana Cario, Muriel Léauté-Labrèze, Christine Taieb, Alain Moisan, François Rezvani, Hamid Reza |
author_sort | Kaulanjan-Checkmodine, Priscilla |
collection | PubMed |
description | Infantile hemangioma (IH) is the most common infantile tumor, affecting 5–10% of newborns. Propranolol, a nonselective β-adrenergic receptor (ADRB) antagonist, is currently the first-line treatment for severe IH; however, both its mechanism of action and its main cellular target remain poorly understood. Since betablockers can antagonize the effect of natural ADRB agonists, we postulated that the catecholamine produced in situ in IH may have a role in the propranolol response. By quantifying catecholamines in the IH tissues, we found a higher amount of noradrenaline (NA) in untreated proliferative IHs than in involuted IHs or propranolol-treated IHs. We further found that the first three enzymes of the catecholamine biosynthesis pathway are expressed by IH cells and that their levels are reduced in propranolol-treated tumors. To study the role of NA in the pathophysiology of IH and its response to propranolol, we performed an in vitro angiogenesis assay in which IH-derived endothelial cells, pericytes and/or telocytes were incorporated. The results showed that the total tube formation is sensitive to propranolol only when exogenous NA is added in the three-cell model. We conclude that the IH’s sensitivity to propranolol depends on crosstalk between the endothelial cells, pericytes and telocytes in the context of a high local amount of local NA. |
format | Online Article Text |
id | pubmed-9104933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91049332022-05-14 Is Infantile Hemangioma a Neuroendocrine Tumor? Kaulanjan-Checkmodine, Priscilla Oucherif, Sandra Prey, Sorilla Gontier, Etienne Lacomme, Sabrina Loot, Maya Miljkovic-Licina, Marijana Cario, Muriel Léauté-Labrèze, Christine Taieb, Alain Moisan, François Rezvani, Hamid Reza Int J Mol Sci Article Infantile hemangioma (IH) is the most common infantile tumor, affecting 5–10% of newborns. Propranolol, a nonselective β-adrenergic receptor (ADRB) antagonist, is currently the first-line treatment for severe IH; however, both its mechanism of action and its main cellular target remain poorly understood. Since betablockers can antagonize the effect of natural ADRB agonists, we postulated that the catecholamine produced in situ in IH may have a role in the propranolol response. By quantifying catecholamines in the IH tissues, we found a higher amount of noradrenaline (NA) in untreated proliferative IHs than in involuted IHs or propranolol-treated IHs. We further found that the first three enzymes of the catecholamine biosynthesis pathway are expressed by IH cells and that their levels are reduced in propranolol-treated tumors. To study the role of NA in the pathophysiology of IH and its response to propranolol, we performed an in vitro angiogenesis assay in which IH-derived endothelial cells, pericytes and/or telocytes were incorporated. The results showed that the total tube formation is sensitive to propranolol only when exogenous NA is added in the three-cell model. We conclude that the IH’s sensitivity to propranolol depends on crosstalk between the endothelial cells, pericytes and telocytes in the context of a high local amount of local NA. MDPI 2022-05-05 /pmc/articles/PMC9104933/ /pubmed/35563552 http://dx.doi.org/10.3390/ijms23095140 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kaulanjan-Checkmodine, Priscilla Oucherif, Sandra Prey, Sorilla Gontier, Etienne Lacomme, Sabrina Loot, Maya Miljkovic-Licina, Marijana Cario, Muriel Léauté-Labrèze, Christine Taieb, Alain Moisan, François Rezvani, Hamid Reza Is Infantile Hemangioma a Neuroendocrine Tumor? |
title | Is Infantile Hemangioma a Neuroendocrine Tumor? |
title_full | Is Infantile Hemangioma a Neuroendocrine Tumor? |
title_fullStr | Is Infantile Hemangioma a Neuroendocrine Tumor? |
title_full_unstemmed | Is Infantile Hemangioma a Neuroendocrine Tumor? |
title_short | Is Infantile Hemangioma a Neuroendocrine Tumor? |
title_sort | is infantile hemangioma a neuroendocrine tumor? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104933/ https://www.ncbi.nlm.nih.gov/pubmed/35563552 http://dx.doi.org/10.3390/ijms23095140 |
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