Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators †

Neuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-µs release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, ni...

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Detalles Bibliográficos
Autores principales: Papageorgiou, George, Corrie, John E. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104977/
https://www.ncbi.nlm.nih.gov/pubmed/35565996
http://dx.doi.org/10.3390/molecules27092645
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author Papageorgiou, George
Corrie, John E. T.
author_facet Papageorgiou, George
Corrie, John E. T.
author_sort Papageorgiou, George
collection PubMed
description Neuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-µs release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, nitroindolinyl-caged BAPTA is found to be completely photostable, whereas nitroindolinyl-caged EDTA photolyses only when saturated with calcium ions.
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spelling pubmed-91049772022-05-14 Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators † Papageorgiou, George Corrie, John E. T. Molecules Article Neuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-µs release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, nitroindolinyl-caged BAPTA is found to be completely photostable, whereas nitroindolinyl-caged EDTA photolyses only when saturated with calcium ions. MDPI 2022-04-20 /pmc/articles/PMC9104977/ /pubmed/35565996 http://dx.doi.org/10.3390/molecules27092645 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Papageorgiou, George
Corrie, John E. T.
Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators †
title Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators †
title_full Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators †
title_fullStr Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators †
title_full_unstemmed Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators †
title_short Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators †
title_sort synthesis and photolytic assessment of nitroindolinyl-caged calcium ion chelators †
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104977/
https://www.ncbi.nlm.nih.gov/pubmed/35565996
http://dx.doi.org/10.3390/molecules27092645
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