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The Endolysosomal System: The Acid Test for SARS-CoV-2

This review aims to describe and discuss the different functions of the endolysosomal system, from homeostasis to its vital role during viral infections. We will initially describe endolysosomal system’s main functions, presenting recent data on how its compartments are essential for host defense to...

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Detalles Bibliográficos
Autores principales: Cesar-Silva, Daniella, Pereira-Dutra, Filipe S., Moraes Giannini, Ana Lucia, Jacques G. de Almeida, Cecília
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105036/
https://www.ncbi.nlm.nih.gov/pubmed/35562967
http://dx.doi.org/10.3390/ijms23094576
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author Cesar-Silva, Daniella
Pereira-Dutra, Filipe S.
Moraes Giannini, Ana Lucia
Jacques G. de Almeida, Cecília
author_facet Cesar-Silva, Daniella
Pereira-Dutra, Filipe S.
Moraes Giannini, Ana Lucia
Jacques G. de Almeida, Cecília
author_sort Cesar-Silva, Daniella
collection PubMed
description This review aims to describe and discuss the different functions of the endolysosomal system, from homeostasis to its vital role during viral infections. We will initially describe endolysosomal system’s main functions, presenting recent data on how its compartments are essential for host defense to explore later how SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) and other coronaviruses subvert these organelles for their benefit. It is clear that to succeed, pathogens’ evolution favored the establishment of ways to avoid, escape, or manipulate lysosomal function. The unavoidable coexistence with such an unfriendly milieu imposed on viruses the establishment of a vast array of strategies to make the most out of the invaded cell’s machinery to produce new viruses and maneuvers to escape the host’s defense system.
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spelling pubmed-91050362022-05-14 The Endolysosomal System: The Acid Test for SARS-CoV-2 Cesar-Silva, Daniella Pereira-Dutra, Filipe S. Moraes Giannini, Ana Lucia Jacques G. de Almeida, Cecília Int J Mol Sci Review This review aims to describe and discuss the different functions of the endolysosomal system, from homeostasis to its vital role during viral infections. We will initially describe endolysosomal system’s main functions, presenting recent data on how its compartments are essential for host defense to explore later how SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) and other coronaviruses subvert these organelles for their benefit. It is clear that to succeed, pathogens’ evolution favored the establishment of ways to avoid, escape, or manipulate lysosomal function. The unavoidable coexistence with such an unfriendly milieu imposed on viruses the establishment of a vast array of strategies to make the most out of the invaded cell’s machinery to produce new viruses and maneuvers to escape the host’s defense system. MDPI 2022-04-20 /pmc/articles/PMC9105036/ /pubmed/35562967 http://dx.doi.org/10.3390/ijms23094576 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cesar-Silva, Daniella
Pereira-Dutra, Filipe S.
Moraes Giannini, Ana Lucia
Jacques G. de Almeida, Cecília
The Endolysosomal System: The Acid Test for SARS-CoV-2
title The Endolysosomal System: The Acid Test for SARS-CoV-2
title_full The Endolysosomal System: The Acid Test for SARS-CoV-2
title_fullStr The Endolysosomal System: The Acid Test for SARS-CoV-2
title_full_unstemmed The Endolysosomal System: The Acid Test for SARS-CoV-2
title_short The Endolysosomal System: The Acid Test for SARS-CoV-2
title_sort endolysosomal system: the acid test for sars-cov-2
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105036/
https://www.ncbi.nlm.nih.gov/pubmed/35562967
http://dx.doi.org/10.3390/ijms23094576
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