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The Endolysosomal System: The Acid Test for SARS-CoV-2
This review aims to describe and discuss the different functions of the endolysosomal system, from homeostasis to its vital role during viral infections. We will initially describe endolysosomal system’s main functions, presenting recent data on how its compartments are essential for host defense to...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105036/ https://www.ncbi.nlm.nih.gov/pubmed/35562967 http://dx.doi.org/10.3390/ijms23094576 |
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author | Cesar-Silva, Daniella Pereira-Dutra, Filipe S. Moraes Giannini, Ana Lucia Jacques G. de Almeida, Cecília |
author_facet | Cesar-Silva, Daniella Pereira-Dutra, Filipe S. Moraes Giannini, Ana Lucia Jacques G. de Almeida, Cecília |
author_sort | Cesar-Silva, Daniella |
collection | PubMed |
description | This review aims to describe and discuss the different functions of the endolysosomal system, from homeostasis to its vital role during viral infections. We will initially describe endolysosomal system’s main functions, presenting recent data on how its compartments are essential for host defense to explore later how SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) and other coronaviruses subvert these organelles for their benefit. It is clear that to succeed, pathogens’ evolution favored the establishment of ways to avoid, escape, or manipulate lysosomal function. The unavoidable coexistence with such an unfriendly milieu imposed on viruses the establishment of a vast array of strategies to make the most out of the invaded cell’s machinery to produce new viruses and maneuvers to escape the host’s defense system. |
format | Online Article Text |
id | pubmed-9105036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91050362022-05-14 The Endolysosomal System: The Acid Test for SARS-CoV-2 Cesar-Silva, Daniella Pereira-Dutra, Filipe S. Moraes Giannini, Ana Lucia Jacques G. de Almeida, Cecília Int J Mol Sci Review This review aims to describe and discuss the different functions of the endolysosomal system, from homeostasis to its vital role during viral infections. We will initially describe endolysosomal system’s main functions, presenting recent data on how its compartments are essential for host defense to explore later how SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) and other coronaviruses subvert these organelles for their benefit. It is clear that to succeed, pathogens’ evolution favored the establishment of ways to avoid, escape, or manipulate lysosomal function. The unavoidable coexistence with such an unfriendly milieu imposed on viruses the establishment of a vast array of strategies to make the most out of the invaded cell’s machinery to produce new viruses and maneuvers to escape the host’s defense system. MDPI 2022-04-20 /pmc/articles/PMC9105036/ /pubmed/35562967 http://dx.doi.org/10.3390/ijms23094576 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cesar-Silva, Daniella Pereira-Dutra, Filipe S. Moraes Giannini, Ana Lucia Jacques G. de Almeida, Cecília The Endolysosomal System: The Acid Test for SARS-CoV-2 |
title | The Endolysosomal System: The Acid Test for SARS-CoV-2 |
title_full | The Endolysosomal System: The Acid Test for SARS-CoV-2 |
title_fullStr | The Endolysosomal System: The Acid Test for SARS-CoV-2 |
title_full_unstemmed | The Endolysosomal System: The Acid Test for SARS-CoV-2 |
title_short | The Endolysosomal System: The Acid Test for SARS-CoV-2 |
title_sort | endolysosomal system: the acid test for sars-cov-2 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105036/ https://www.ncbi.nlm.nih.gov/pubmed/35562967 http://dx.doi.org/10.3390/ijms23094576 |
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