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Maternal Iodine Intake and Neurodevelopment of Offspring: The Japan Environment and Children’s Study
Inadequate maternal iodine intake affects thyroid function and may impair fetal brain development. This study investigated the association between maternal iodine intake during pregnancy and neurodevelopmental delay in offspring at 1 and 3 years of age using a nationwide birth cohort: the Japan Envi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105063/ https://www.ncbi.nlm.nih.gov/pubmed/35565793 http://dx.doi.org/10.3390/nu14091826 |
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author | Hisada, Aya Takatani, Rieko Yamamoto, Midori Nakaoka, Hiroko Sakurai, Kenichi Mori, Chisato |
author_facet | Hisada, Aya Takatani, Rieko Yamamoto, Midori Nakaoka, Hiroko Sakurai, Kenichi Mori, Chisato |
author_sort | Hisada, Aya |
collection | PubMed |
description | Inadequate maternal iodine intake affects thyroid function and may impair fetal brain development. This study investigated the association between maternal iodine intake during pregnancy and neurodevelopmental delay in offspring at 1 and 3 years of age using a nationwide birth cohort: the Japan Environment and Children’s Study. We assessed dietary iodine intake during pregnancy using a food frequency questionnaire and child neurodevelopment using the Japanese translation of the Ages and Stages Questionnaire, Third Edition. The risk of delay (score below the cut-off value) for fine motor domain at 1 year of age was increased in the lowest quintile iodine intake group compared with the fourth quintile iodine intake group. The risk of delay for problem-solving at 1 year of age was increased in the lowest and second quintile iodine intake group and decreased in the highest quintile iodine intake group. The risk of delay for communication, fine motor, problem-solving, and personal–social domains at 3 years of age was increased in the lowest and second quintile iodine intake group compared with the fourth quintile iodine intake group, while the risk of delay for fine motor and problem-solving domains was decreased in the highest quintile iodine intake group. Low iodine intake levels in pregnancy may affect child neurodevelopment. |
format | Online Article Text |
id | pubmed-9105063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91050632022-05-14 Maternal Iodine Intake and Neurodevelopment of Offspring: The Japan Environment and Children’s Study Hisada, Aya Takatani, Rieko Yamamoto, Midori Nakaoka, Hiroko Sakurai, Kenichi Mori, Chisato Nutrients Article Inadequate maternal iodine intake affects thyroid function and may impair fetal brain development. This study investigated the association between maternal iodine intake during pregnancy and neurodevelopmental delay in offspring at 1 and 3 years of age using a nationwide birth cohort: the Japan Environment and Children’s Study. We assessed dietary iodine intake during pregnancy using a food frequency questionnaire and child neurodevelopment using the Japanese translation of the Ages and Stages Questionnaire, Third Edition. The risk of delay (score below the cut-off value) for fine motor domain at 1 year of age was increased in the lowest quintile iodine intake group compared with the fourth quintile iodine intake group. The risk of delay for problem-solving at 1 year of age was increased in the lowest and second quintile iodine intake group and decreased in the highest quintile iodine intake group. The risk of delay for communication, fine motor, problem-solving, and personal–social domains at 3 years of age was increased in the lowest and second quintile iodine intake group compared with the fourth quintile iodine intake group, while the risk of delay for fine motor and problem-solving domains was decreased in the highest quintile iodine intake group. Low iodine intake levels in pregnancy may affect child neurodevelopment. MDPI 2022-04-27 /pmc/articles/PMC9105063/ /pubmed/35565793 http://dx.doi.org/10.3390/nu14091826 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hisada, Aya Takatani, Rieko Yamamoto, Midori Nakaoka, Hiroko Sakurai, Kenichi Mori, Chisato Maternal Iodine Intake and Neurodevelopment of Offspring: The Japan Environment and Children’s Study |
title | Maternal Iodine Intake and Neurodevelopment of Offspring: The Japan Environment and Children’s Study |
title_full | Maternal Iodine Intake and Neurodevelopment of Offspring: The Japan Environment and Children’s Study |
title_fullStr | Maternal Iodine Intake and Neurodevelopment of Offspring: The Japan Environment and Children’s Study |
title_full_unstemmed | Maternal Iodine Intake and Neurodevelopment of Offspring: The Japan Environment and Children’s Study |
title_short | Maternal Iodine Intake and Neurodevelopment of Offspring: The Japan Environment and Children’s Study |
title_sort | maternal iodine intake and neurodevelopment of offspring: the japan environment and children’s study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105063/ https://www.ncbi.nlm.nih.gov/pubmed/35565793 http://dx.doi.org/10.3390/nu14091826 |
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