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Multiomics Approach Reveals an Important Role of BNIP3 in Myocardial Remodeling and the Pathogenesis of Heart Failure with Reduced Ejection Fraction

Previous work showed a role of BNIP3 in myocardial remodeling and progression to HFrEF. We utilized a multiomics approach to unravel BNIP3-related molecular mechanisms in the pathogenesis of HFrEF. BNIP3 knockdown in HFrEF improved glycolysis, pyruvate metabolism, branched-chain amino acid catabolis...

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Detalles Bibliográficos
Autores principales:	Chaanine, Antoine H., Higgins, LeeAnn, Lauterboeck, Lothar, Markowski, Todd, Yang, Qinglin, Delafontaine, Patrice
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105187/ https://www.ncbi.nlm.nih.gov/pubmed/35563877 http://dx.doi.org/10.3390/cells11091572

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