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Nigella sativa L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature

COVID-19 has had an impact on human quality of life and economics. Scientists have been identifying remedies for its prevention and treatment from all possible sources, including plants. Nigella sativa L. (NS) is an important medicinal plant of Islamic value. This review highlights the anti-COVID-19...

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Autores principales: Imran, Mohd, Khan, Shah Alam, Abida, Alshammari, Mohammed Kanan, Alkhaldi, Saif M., Alshammari, Fayez Nafea, Kamal, Mehnaz, Alam, Ozair, Asdaq, Syed Mohammed Basheeruddin, Alzahrani, A. Khuzaim, Jomah, Shahamah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105261/
https://www.ncbi.nlm.nih.gov/pubmed/35566101
http://dx.doi.org/10.3390/molecules27092750
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author Imran, Mohd
Khan, Shah Alam
Abida,
Alshammari, Mohammed Kanan
Alkhaldi, Saif M.
Alshammari, Fayez Nafea
Kamal, Mehnaz
Alam, Ozair
Asdaq, Syed Mohammed Basheeruddin
Alzahrani, A. Khuzaim
Jomah, Shahamah
author_facet Imran, Mohd
Khan, Shah Alam
Abida,
Alshammari, Mohammed Kanan
Alkhaldi, Saif M.
Alshammari, Fayez Nafea
Kamal, Mehnaz
Alam, Ozair
Asdaq, Syed Mohammed Basheeruddin
Alzahrani, A. Khuzaim
Jomah, Shahamah
author_sort Imran, Mohd
collection PubMed
description COVID-19 has had an impact on human quality of life and economics. Scientists have been identifying remedies for its prevention and treatment from all possible sources, including plants. Nigella sativa L. (NS) is an important medicinal plant of Islamic value. This review highlights the anti-COVID-19 potential, clinical trials, inventions, and patent literature related to NS and its major chemical constituents, like thymoquinone. The literature was collected from different databases, including Pubmed, Espacenet, and Patentscope. The literature supports the efficacy of NS, NS oil (NSO), and its chemical constituents against COVID-19. The clinical data imply that NS and NSO can prevent and treat COVID-19 patients with a faster recovery rate. Several inventions comprising NS and NSO have been claimed in patent applications to prevent/treat COVID-19. The patent literature cites NS as an immunomodulator, antioxidant, anti-inflammatory, a source of anti-SARS-CoV-2 compounds, and a plant having protective effects on the lungs. The available facts indicate that NS, NSO, and its various compositions have all the attributes to be used as a promising remedy to prevent, manage, and treat COVID-19 among high-risk people as well as for the therapy of COVID-19 patients of all age groups as a monotherapy or a combination therapy. Many compositions of NS in combination with countless medicinal herbs and medicines are still unexplored. Accordingly, the authors foresee a bright scope in developing NS-based anti-COVID-19 composition for clinical use in the future.
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spelling pubmed-91052612022-05-14 Nigella sativa L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature Imran, Mohd Khan, Shah Alam Abida, Alshammari, Mohammed Kanan Alkhaldi, Saif M. Alshammari, Fayez Nafea Kamal, Mehnaz Alam, Ozair Asdaq, Syed Mohammed Basheeruddin Alzahrani, A. Khuzaim Jomah, Shahamah Molecules Review COVID-19 has had an impact on human quality of life and economics. Scientists have been identifying remedies for its prevention and treatment from all possible sources, including plants. Nigella sativa L. (NS) is an important medicinal plant of Islamic value. This review highlights the anti-COVID-19 potential, clinical trials, inventions, and patent literature related to NS and its major chemical constituents, like thymoquinone. The literature was collected from different databases, including Pubmed, Espacenet, and Patentscope. The literature supports the efficacy of NS, NS oil (NSO), and its chemical constituents against COVID-19. The clinical data imply that NS and NSO can prevent and treat COVID-19 patients with a faster recovery rate. Several inventions comprising NS and NSO have been claimed in patent applications to prevent/treat COVID-19. The patent literature cites NS as an immunomodulator, antioxidant, anti-inflammatory, a source of anti-SARS-CoV-2 compounds, and a plant having protective effects on the lungs. The available facts indicate that NS, NSO, and its various compositions have all the attributes to be used as a promising remedy to prevent, manage, and treat COVID-19 among high-risk people as well as for the therapy of COVID-19 patients of all age groups as a monotherapy or a combination therapy. Many compositions of NS in combination with countless medicinal herbs and medicines are still unexplored. Accordingly, the authors foresee a bright scope in developing NS-based anti-COVID-19 composition for clinical use in the future. MDPI 2022-04-25 /pmc/articles/PMC9105261/ /pubmed/35566101 http://dx.doi.org/10.3390/molecules27092750 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Imran, Mohd
Khan, Shah Alam
Abida,
Alshammari, Mohammed Kanan
Alkhaldi, Saif M.
Alshammari, Fayez Nafea
Kamal, Mehnaz
Alam, Ozair
Asdaq, Syed Mohammed Basheeruddin
Alzahrani, A. Khuzaim
Jomah, Shahamah
Nigella sativa L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature
title Nigella sativa L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature
title_full Nigella sativa L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature
title_fullStr Nigella sativa L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature
title_full_unstemmed Nigella sativa L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature
title_short Nigella sativa L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature
title_sort nigella sativa l. and covid-19: a glance at the anti-covid-19 chemical constituents, clinical trials, inventions, and patent literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105261/
https://www.ncbi.nlm.nih.gov/pubmed/35566101
http://dx.doi.org/10.3390/molecules27092750
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