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Combination of CENP-B Box Positive and Negative Synthetic Alpha Satellite Repeats Improves De Novo Human Artificial Chromosome Formation

Human artificial chromosomes (HACs) can be formed de novo by introducing large (>30 kb) centromeric sequences consisting of highly repeated 171-bp alpha satellite (alphoid) DNA into HT1080 cells. However, only a subset of transformed cells successfully establishes HACs. CENP-A chromatin and heter...

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Detalles Bibliográficos
Autores principales:	Okazaki, Koei, Nakano, Megumi, Ohzeki, Jun-ichirou, Otake, Koichiro, Kugou, Kazuto, Larionov, Vladimir, Earnshaw, William C., Masumoto, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105310/ https://www.ncbi.nlm.nih.gov/pubmed/35563684 http://dx.doi.org/10.3390/cells11091378

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