Cargando…
Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage
Excessive fructose intake is associated with the increased risk of mental illness, such as depression, but the underlying mechanisms are poorly understood. Our previous study found that high fructose diet (FruD)-fed mice exhibited neuroinflammation, hippocampal neurogenesis decline and blood–brain b...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105414/ https://www.ncbi.nlm.nih.gov/pubmed/35565849 http://dx.doi.org/10.3390/nu14091882 |
_version_ | 1784708034673508352 |
---|---|
author | Tang, Chuan-Feng Wang, Cong-Ying Wang, Jun-Han Wang, Qiao-Na Li, Shen-Jie Wang, Hai-Ou Zhou, Feng Li, Jian-Mei |
author_facet | Tang, Chuan-Feng Wang, Cong-Ying Wang, Jun-Han Wang, Qiao-Na Li, Shen-Jie Wang, Hai-Ou Zhou, Feng Li, Jian-Mei |
author_sort | Tang, Chuan-Feng |
collection | PubMed |
description | Excessive fructose intake is associated with the increased risk of mental illness, such as depression, but the underlying mechanisms are poorly understood. Our previous study found that high fructose diet (FruD)-fed mice exhibited neuroinflammation, hippocampal neurogenesis decline and blood–brain barrier (BBB) damage, accompanied by the reduction of gut microbiome-derived short-chain fatty acids (SCFAs). Here, we found that chronic stress aggravated these pathological changes and promoted the development of depressive-like behaviors in FruD mice. In detail, the decreased number of newborn neurons, mature neurons and neural stem cells (NSCs) in the hippocampus of FruD mice was worsened by chronic stress. Furthermore, chronic stress exacerbated the damage of BBB integrity with the decreased expression of zonula occludens-1 (ZO-1), claudin-5 and occludin in brain vasculature, overactivated microglia and increased neuroinflammation in FruD mice. These results suggest that high fructose intake combined with chronic stress leads to cumulative negative effects that promote the development of depressive-like behaviors in mice. Of note, SCFAs could rescue hippocampal neurogenesis decline, improve BBB damage and suppress microglia activation and neuroinflammation, thereby ameliorate depressive-like behaviors of FruD mice exposed to chronic stress. These results could be used to develop dietary interventions to prevent depression. |
format | Online Article Text |
id | pubmed-9105414 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91054142022-05-14 Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage Tang, Chuan-Feng Wang, Cong-Ying Wang, Jun-Han Wang, Qiao-Na Li, Shen-Jie Wang, Hai-Ou Zhou, Feng Li, Jian-Mei Nutrients Article Excessive fructose intake is associated with the increased risk of mental illness, such as depression, but the underlying mechanisms are poorly understood. Our previous study found that high fructose diet (FruD)-fed mice exhibited neuroinflammation, hippocampal neurogenesis decline and blood–brain barrier (BBB) damage, accompanied by the reduction of gut microbiome-derived short-chain fatty acids (SCFAs). Here, we found that chronic stress aggravated these pathological changes and promoted the development of depressive-like behaviors in FruD mice. In detail, the decreased number of newborn neurons, mature neurons and neural stem cells (NSCs) in the hippocampus of FruD mice was worsened by chronic stress. Furthermore, chronic stress exacerbated the damage of BBB integrity with the decreased expression of zonula occludens-1 (ZO-1), claudin-5 and occludin in brain vasculature, overactivated microglia and increased neuroinflammation in FruD mice. These results suggest that high fructose intake combined with chronic stress leads to cumulative negative effects that promote the development of depressive-like behaviors in mice. Of note, SCFAs could rescue hippocampal neurogenesis decline, improve BBB damage and suppress microglia activation and neuroinflammation, thereby ameliorate depressive-like behaviors of FruD mice exposed to chronic stress. These results could be used to develop dietary interventions to prevent depression. MDPI 2022-04-29 /pmc/articles/PMC9105414/ /pubmed/35565849 http://dx.doi.org/10.3390/nu14091882 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tang, Chuan-Feng Wang, Cong-Ying Wang, Jun-Han Wang, Qiao-Na Li, Shen-Jie Wang, Hai-Ou Zhou, Feng Li, Jian-Mei Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage |
title | Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage |
title_full | Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage |
title_fullStr | Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage |
title_full_unstemmed | Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage |
title_short | Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage |
title_sort | short-chain fatty acids ameliorate depressive-like behaviors of high fructose-fed mice by rescuing hippocampal neurogenesis decline and blood–brain barrier damage |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105414/ https://www.ncbi.nlm.nih.gov/pubmed/35565849 http://dx.doi.org/10.3390/nu14091882 |
work_keys_str_mv | AT tangchuanfeng shortchainfattyacidsamelioratedepressivelikebehaviorsofhighfructosefedmicebyrescuinghippocampalneurogenesisdeclineandbloodbrainbarrierdamage AT wangcongying shortchainfattyacidsamelioratedepressivelikebehaviorsofhighfructosefedmicebyrescuinghippocampalneurogenesisdeclineandbloodbrainbarrierdamage AT wangjunhan shortchainfattyacidsamelioratedepressivelikebehaviorsofhighfructosefedmicebyrescuinghippocampalneurogenesisdeclineandbloodbrainbarrierdamage AT wangqiaona shortchainfattyacidsamelioratedepressivelikebehaviorsofhighfructosefedmicebyrescuinghippocampalneurogenesisdeclineandbloodbrainbarrierdamage AT lishenjie shortchainfattyacidsamelioratedepressivelikebehaviorsofhighfructosefedmicebyrescuinghippocampalneurogenesisdeclineandbloodbrainbarrierdamage AT wanghaiou shortchainfattyacidsamelioratedepressivelikebehaviorsofhighfructosefedmicebyrescuinghippocampalneurogenesisdeclineandbloodbrainbarrierdamage AT zhoufeng shortchainfattyacidsamelioratedepressivelikebehaviorsofhighfructosefedmicebyrescuinghippocampalneurogenesisdeclineandbloodbrainbarrierdamage AT lijianmei shortchainfattyacidsamelioratedepressivelikebehaviorsofhighfructosefedmicebyrescuinghippocampalneurogenesisdeclineandbloodbrainbarrierdamage |