Cargando…

Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage

Excessive fructose intake is associated with the increased risk of mental illness, such as depression, but the underlying mechanisms are poorly understood. Our previous study found that high fructose diet (FruD)-fed mice exhibited neuroinflammation, hippocampal neurogenesis decline and blood–brain b...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Chuan-Feng, Wang, Cong-Ying, Wang, Jun-Han, Wang, Qiao-Na, Li, Shen-Jie, Wang, Hai-Ou, Zhou, Feng, Li, Jian-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105414/
https://www.ncbi.nlm.nih.gov/pubmed/35565849
http://dx.doi.org/10.3390/nu14091882
_version_ 1784708034673508352
author Tang, Chuan-Feng
Wang, Cong-Ying
Wang, Jun-Han
Wang, Qiao-Na
Li, Shen-Jie
Wang, Hai-Ou
Zhou, Feng
Li, Jian-Mei
author_facet Tang, Chuan-Feng
Wang, Cong-Ying
Wang, Jun-Han
Wang, Qiao-Na
Li, Shen-Jie
Wang, Hai-Ou
Zhou, Feng
Li, Jian-Mei
author_sort Tang, Chuan-Feng
collection PubMed
description Excessive fructose intake is associated with the increased risk of mental illness, such as depression, but the underlying mechanisms are poorly understood. Our previous study found that high fructose diet (FruD)-fed mice exhibited neuroinflammation, hippocampal neurogenesis decline and blood–brain barrier (BBB) damage, accompanied by the reduction of gut microbiome-derived short-chain fatty acids (SCFAs). Here, we found that chronic stress aggravated these pathological changes and promoted the development of depressive-like behaviors in FruD mice. In detail, the decreased number of newborn neurons, mature neurons and neural stem cells (NSCs) in the hippocampus of FruD mice was worsened by chronic stress. Furthermore, chronic stress exacerbated the damage of BBB integrity with the decreased expression of zonula occludens-1 (ZO-1), claudin-5 and occludin in brain vasculature, overactivated microglia and increased neuroinflammation in FruD mice. These results suggest that high fructose intake combined with chronic stress leads to cumulative negative effects that promote the development of depressive-like behaviors in mice. Of note, SCFAs could rescue hippocampal neurogenesis decline, improve BBB damage and suppress microglia activation and neuroinflammation, thereby ameliorate depressive-like behaviors of FruD mice exposed to chronic stress. These results could be used to develop dietary interventions to prevent depression.
format Online
Article
Text
id pubmed-9105414
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91054142022-05-14 Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage Tang, Chuan-Feng Wang, Cong-Ying Wang, Jun-Han Wang, Qiao-Na Li, Shen-Jie Wang, Hai-Ou Zhou, Feng Li, Jian-Mei Nutrients Article Excessive fructose intake is associated with the increased risk of mental illness, such as depression, but the underlying mechanisms are poorly understood. Our previous study found that high fructose diet (FruD)-fed mice exhibited neuroinflammation, hippocampal neurogenesis decline and blood–brain barrier (BBB) damage, accompanied by the reduction of gut microbiome-derived short-chain fatty acids (SCFAs). Here, we found that chronic stress aggravated these pathological changes and promoted the development of depressive-like behaviors in FruD mice. In detail, the decreased number of newborn neurons, mature neurons and neural stem cells (NSCs) in the hippocampus of FruD mice was worsened by chronic stress. Furthermore, chronic stress exacerbated the damage of BBB integrity with the decreased expression of zonula occludens-1 (ZO-1), claudin-5 and occludin in brain vasculature, overactivated microglia and increased neuroinflammation in FruD mice. These results suggest that high fructose intake combined with chronic stress leads to cumulative negative effects that promote the development of depressive-like behaviors in mice. Of note, SCFAs could rescue hippocampal neurogenesis decline, improve BBB damage and suppress microglia activation and neuroinflammation, thereby ameliorate depressive-like behaviors of FruD mice exposed to chronic stress. These results could be used to develop dietary interventions to prevent depression. MDPI 2022-04-29 /pmc/articles/PMC9105414/ /pubmed/35565849 http://dx.doi.org/10.3390/nu14091882 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tang, Chuan-Feng
Wang, Cong-Ying
Wang, Jun-Han
Wang, Qiao-Na
Li, Shen-Jie
Wang, Hai-Ou
Zhou, Feng
Li, Jian-Mei
Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage
title Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage
title_full Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage
title_fullStr Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage
title_full_unstemmed Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage
title_short Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage
title_sort short-chain fatty acids ameliorate depressive-like behaviors of high fructose-fed mice by rescuing hippocampal neurogenesis decline and blood–brain barrier damage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105414/
https://www.ncbi.nlm.nih.gov/pubmed/35565849
http://dx.doi.org/10.3390/nu14091882
work_keys_str_mv AT tangchuanfeng shortchainfattyacidsamelioratedepressivelikebehaviorsofhighfructosefedmicebyrescuinghippocampalneurogenesisdeclineandbloodbrainbarrierdamage
AT wangcongying shortchainfattyacidsamelioratedepressivelikebehaviorsofhighfructosefedmicebyrescuinghippocampalneurogenesisdeclineandbloodbrainbarrierdamage
AT wangjunhan shortchainfattyacidsamelioratedepressivelikebehaviorsofhighfructosefedmicebyrescuinghippocampalneurogenesisdeclineandbloodbrainbarrierdamage
AT wangqiaona shortchainfattyacidsamelioratedepressivelikebehaviorsofhighfructosefedmicebyrescuinghippocampalneurogenesisdeclineandbloodbrainbarrierdamage
AT lishenjie shortchainfattyacidsamelioratedepressivelikebehaviorsofhighfructosefedmicebyrescuinghippocampalneurogenesisdeclineandbloodbrainbarrierdamage
AT wanghaiou shortchainfattyacidsamelioratedepressivelikebehaviorsofhighfructosefedmicebyrescuinghippocampalneurogenesisdeclineandbloodbrainbarrierdamage
AT zhoufeng shortchainfattyacidsamelioratedepressivelikebehaviorsofhighfructosefedmicebyrescuinghippocampalneurogenesisdeclineandbloodbrainbarrierdamage
AT lijianmei shortchainfattyacidsamelioratedepressivelikebehaviorsofhighfructosefedmicebyrescuinghippocampalneurogenesisdeclineandbloodbrainbarrierdamage