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Cognitive Functions Associated with Brain Imaging Markers in Patients with Psoriasis

Psoriasis is a severe inflammatory disease associated with a higher comorbidity of depression, cognitive dysfunction and brain atrophy. The association between psoriasis, magnetic resonance imaging (MRI) markers and cognitive impairment has rarely been investigated, and the existing results are conf...

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Autores principales: Marek-Jozefowicz, Luiza, Lemanowicz, Adam, Grochocka, Małgorzata, Wróblewska, Monika, Białczyk, Katarzyna, Piec, Katarzyna, Kozera, Grzegorz M., Serafin, Zbigniew, Czajkowski, Rafał, Borkowska, Alina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105445/
https://www.ncbi.nlm.nih.gov/pubmed/35565082
http://dx.doi.org/10.3390/ijerph19095687
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author Marek-Jozefowicz, Luiza
Lemanowicz, Adam
Grochocka, Małgorzata
Wróblewska, Monika
Białczyk, Katarzyna
Piec, Katarzyna
Kozera, Grzegorz M.
Serafin, Zbigniew
Czajkowski, Rafał
Borkowska, Alina
author_facet Marek-Jozefowicz, Luiza
Lemanowicz, Adam
Grochocka, Małgorzata
Wróblewska, Monika
Białczyk, Katarzyna
Piec, Katarzyna
Kozera, Grzegorz M.
Serafin, Zbigniew
Czajkowski, Rafał
Borkowska, Alina
author_sort Marek-Jozefowicz, Luiza
collection PubMed
description Psoriasis is a severe inflammatory disease associated with a higher comorbidity of depression, cognitive dysfunction and brain atrophy. The association between psoriasis, magnetic resonance imaging (MRI) markers and cognitive impairment has rarely been investigated, and the existing results are conflicting. Methods. This study included 89 subjects (53 patients with psoriasis and 36 healthy controls). The severity of psoriasis was evaluated using the Psoriasis Area and Severity Index (PASI) score; for depression, the Hospital Anxiety and Depression Scale (HADS) scale was used. Neuropsychological tests were also applied, including a Trail Making Test (TMT) as well as Digit Span, Stroop, Verbal Fluency and Rey Auditory Verbal Learning tests. MRI scans were performed using a 1.5 T scanner. Brain volumetry, white matter lesions, grey matter and white matter were evaluated. The extent of these changes was assessed on the Fazekas scale. The differences between groups were evaluated using a Student’s t-test and a Mann-Whitney U test, and a Pearson correlation analysis was also performed. Results. Patients with psoriasis presented worse achievements on all the neuropsychological tests and showed more intense changes on MRI compared to healthy controls. The severity of psoriasis as determined by PASI scores was associated with depression, and a greater psychomotor slowness severity of changes in the brain was associated with poorer results on the neurological tests. Conclusions. Our results indicate the possibility of progressive brain atrophy related to cognitive decline in psoriasis.
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spelling pubmed-91054452022-05-14 Cognitive Functions Associated with Brain Imaging Markers in Patients with Psoriasis Marek-Jozefowicz, Luiza Lemanowicz, Adam Grochocka, Małgorzata Wróblewska, Monika Białczyk, Katarzyna Piec, Katarzyna Kozera, Grzegorz M. Serafin, Zbigniew Czajkowski, Rafał Borkowska, Alina Int J Environ Res Public Health Article Psoriasis is a severe inflammatory disease associated with a higher comorbidity of depression, cognitive dysfunction and brain atrophy. The association between psoriasis, magnetic resonance imaging (MRI) markers and cognitive impairment has rarely been investigated, and the existing results are conflicting. Methods. This study included 89 subjects (53 patients with psoriasis and 36 healthy controls). The severity of psoriasis was evaluated using the Psoriasis Area and Severity Index (PASI) score; for depression, the Hospital Anxiety and Depression Scale (HADS) scale was used. Neuropsychological tests were also applied, including a Trail Making Test (TMT) as well as Digit Span, Stroop, Verbal Fluency and Rey Auditory Verbal Learning tests. MRI scans were performed using a 1.5 T scanner. Brain volumetry, white matter lesions, grey matter and white matter were evaluated. The extent of these changes was assessed on the Fazekas scale. The differences between groups were evaluated using a Student’s t-test and a Mann-Whitney U test, and a Pearson correlation analysis was also performed. Results. Patients with psoriasis presented worse achievements on all the neuropsychological tests and showed more intense changes on MRI compared to healthy controls. The severity of psoriasis as determined by PASI scores was associated with depression, and a greater psychomotor slowness severity of changes in the brain was associated with poorer results on the neurological tests. Conclusions. Our results indicate the possibility of progressive brain atrophy related to cognitive decline in psoriasis. MDPI 2022-05-07 /pmc/articles/PMC9105445/ /pubmed/35565082 http://dx.doi.org/10.3390/ijerph19095687 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marek-Jozefowicz, Luiza
Lemanowicz, Adam
Grochocka, Małgorzata
Wróblewska, Monika
Białczyk, Katarzyna
Piec, Katarzyna
Kozera, Grzegorz M.
Serafin, Zbigniew
Czajkowski, Rafał
Borkowska, Alina
Cognitive Functions Associated with Brain Imaging Markers in Patients with Psoriasis
title Cognitive Functions Associated with Brain Imaging Markers in Patients with Psoriasis
title_full Cognitive Functions Associated with Brain Imaging Markers in Patients with Psoriasis
title_fullStr Cognitive Functions Associated with Brain Imaging Markers in Patients with Psoriasis
title_full_unstemmed Cognitive Functions Associated with Brain Imaging Markers in Patients with Psoriasis
title_short Cognitive Functions Associated with Brain Imaging Markers in Patients with Psoriasis
title_sort cognitive functions associated with brain imaging markers in patients with psoriasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105445/
https://www.ncbi.nlm.nih.gov/pubmed/35565082
http://dx.doi.org/10.3390/ijerph19095687
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