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Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder
Rapid eye movement (REM) sleep behaviour disorder (RBD) is a REM parasomnia that often predicts the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105586/ https://www.ncbi.nlm.nih.gov/pubmed/35562385 http://dx.doi.org/10.1038/s41598-022-11516-x |
| _version_ | 1784708076614451200 |
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| author | Gelegen, Cigdem Cash, Diana Ilic, Katarina Sander, Millie Kim, Eugene Simmons, Camilla Bernanos, Michel Lama, Joana Randall, Karen Brown, Jonathan T. Kalanj-Bognar, Svjetlana Cooke, Samuel Ray Chaudhuri, K. Ballard, Clive Francis, Paul Rosenzweig, Ivana |
| author_facet | Gelegen, Cigdem Cash, Diana Ilic, Katarina Sander, Millie Kim, Eugene Simmons, Camilla Bernanos, Michel Lama, Joana Randall, Karen Brown, Jonathan T. Kalanj-Bognar, Svjetlana Cooke, Samuel Ray Chaudhuri, K. Ballard, Clive Francis, Paul Rosenzweig, Ivana |
| author_sort | Gelegen, Cigdem |
| collection | PubMed |
| description | Rapid eye movement (REM) sleep behaviour disorder (RBD) is a REM parasomnia that often predicts the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to mimic prodromal stages of α-synucleinopathy, we now demonstrate striking REM and NREM electroencephalographic sleep abnormalities accompanied by distinct structural changes in the more widespread sleep neurocircuitry. |
| format | Online Article Text |
| id | pubmed-9105586 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-91055862022-05-15 Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder Gelegen, Cigdem Cash, Diana Ilic, Katarina Sander, Millie Kim, Eugene Simmons, Camilla Bernanos, Michel Lama, Joana Randall, Karen Brown, Jonathan T. Kalanj-Bognar, Svjetlana Cooke, Samuel Ray Chaudhuri, K. Ballard, Clive Francis, Paul Rosenzweig, Ivana Sci Rep Article Rapid eye movement (REM) sleep behaviour disorder (RBD) is a REM parasomnia that often predicts the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to mimic prodromal stages of α-synucleinopathy, we now demonstrate striking REM and NREM electroencephalographic sleep abnormalities accompanied by distinct structural changes in the more widespread sleep neurocircuitry. Nature Publishing Group UK 2022-05-13 /pmc/articles/PMC9105586/ /pubmed/35562385 http://dx.doi.org/10.1038/s41598-022-11516-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Gelegen, Cigdem Cash, Diana Ilic, Katarina Sander, Millie Kim, Eugene Simmons, Camilla Bernanos, Michel Lama, Joana Randall, Karen Brown, Jonathan T. Kalanj-Bognar, Svjetlana Cooke, Samuel Ray Chaudhuri, K. Ballard, Clive Francis, Paul Rosenzweig, Ivana Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder |
| title | Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder |
| title_full | Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder |
| title_fullStr | Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder |
| title_full_unstemmed | Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder |
| title_short | Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder |
| title_sort | relevance of sleep and associated structural changes in gba1 mouse to human rapid eye movement behavior disorder |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105586/ https://www.ncbi.nlm.nih.gov/pubmed/35562385 http://dx.doi.org/10.1038/s41598-022-11516-x |
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