Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder

Rapid eye movement (REM) sleep behaviour disorder (RBD) is a REM parasomnia that often predicts the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to...

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Detalles Bibliográficos
Autores principales: Gelegen, Cigdem, Cash, Diana, Ilic, Katarina, Sander, Millie, Kim, Eugene, Simmons, Camilla, Bernanos, Michel, Lama, Joana, Randall, Karen, Brown, Jonathan T., Kalanj-Bognar, Svjetlana, Cooke, Samuel, Ray Chaudhuri, K., Ballard, Clive, Francis, Paul, Rosenzweig, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105586/
https://www.ncbi.nlm.nih.gov/pubmed/35562385
http://dx.doi.org/10.1038/s41598-022-11516-x

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