Cargando…

The Cellular Tumor Immune Microenvironment of Childhood Solid Cancers: Informing More Effective Immunotherapies

SIMPLE SUMMARY: Cellular immunotherapy has emerged as a novel treatment modality of cancer but is largely inefficient in solid cancers of childhood and adolescence. Besides tumor cells, solid cancers contain various bystander cell populations that can suppress immune responses and prevent the action...

Descripción completa

Detalles Bibliográficos
Autores principales:	Holterhus, Malcolm, Altvater, Bianca, Kailayangiri, Sareetha, Rossig, Claudia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105669/ https://www.ncbi.nlm.nih.gov/pubmed/35565307 http://dx.doi.org/10.3390/cancers14092177

Ejemplares similares

Carbohydrate Targets for CAR T Cells in Solid Childhood Cancers
por: Rossig, Claudia, et al.
Publicado: (2018)

Overcoming Heterogeneity of Antigen Expression for Effective CAR T Cell Targeting of Cancers
por: Kailayangiri, Sareetha, et al.
Publicado: (2020)

Surface expression of the immunotherapeutic target G(D2) in osteosarcoma depends on cell confluency
por: Wiebel, Malena, et al.
Publicado: (2021)

HLA-G and HLA-E Immune Checkpoints Are Widely Expressed in Ewing Sarcoma but Have Limited Functional Impact on the Effector Functions of Antigen-Specific CAR T Cells
por: Altvater, Bianca, et al.
Publicado: (2021)

T cell infiltration into Ewing sarcomas is associated with local expression of immune-inhibitory HLA-G
por: Spurny, Christian, et al.
Publicado: (2017)

CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process
por: Altvater, Bianca, et al.
Publicado: (2023)

Relevance of Abnormal KCNN1 Expression and Osmotic Hypersensitivity in Ewing Sarcoma
por: Fuest, Sebastian, et al.
Publicado: (2022)

The ganglioside antigen G(D2) is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting
por: Kailayangiri, S, et al.
Publicado: (2012)

Ewing sarcoma dissemination and response to T-cell therapy in mice assessed by whole-body magnetic resonance imaging
por: Liebsch, L, et al.
Publicado: (2013)

Extending the chimeric receptor-based T-cell targeting strategy to solid tumors
por: Rossig, Claudia
Publicado: (2013)

Mast Cells and Dendritic Cells as Cellular Immune Checkpoints in Immunotherapy of Solid Tumors
por: Kalkusova, Katerina, et al.
Publicado: (2022)

Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors
por: Xu, Liangliang, et al.
Publicado: (2022)

Vascular Microenvironment, Tumor Immunity and Immunotherapy
por: Lamplugh, Zachary, et al.
Publicado: (2021)

Immunotherapy: Reshape the Tumor Immune Microenvironment
por: LV, Bingzhe, et al.
Publicado: (2022)

Targeting Cellular Components of the Tumor Microenvironment in Solid Malignancies
por: Belli, Carmen, et al.
Publicado: (2022)

Role of the tumor immune microenvironment in tumor immunotherapy
por: Zhou, Changsheng, et al.
Publicado: (2022)

Co-mutations in tumor immune microenvironment and immunotherapy
por: Ma, Ling, et al.
Publicado: (2021)

Modelling the tumor immune microenvironment for precision immunotherapy
por: Mackenzie, Nathan J, et al.
Publicado: (2022)

Implications for Immunotherapy of Breast Cancer by Understanding the Microenvironment of a Solid Tumor
por: Franzén, Alexander S., et al.
Publicado: (2022)

Recent Progress on Immunotherapy for Breast Cancer: Tumor Microenvironment, Nanotechnology and More
por: Li, Yang, et al.
Publicado: (2021)

Microenvironments and Cellular Characteristics in the Micro Tumor Cords of Malignant Solid Tumors
por: Yeom, Chan Joo, et al.
Publicado: (2012)

SS18-SSX drives CREB activation in synovial sarcoma
por: Cyra, Magdalene, et al.
Publicado: (2022)

Hijacked Immune Cells in the Tumor Microenvironment: Molecular Mechanisms of Immunosuppression and Cues to Improve T Cell-Based Immunotherapy of Solid Tumors
por: Balta, Emre, et al.
Publicado: (2021)

Variable Expression of the Disialoganglioside GD2 in Breast Cancer Molecular Subtypes
por: Erber, Ramona, et al.
Publicado: (2021)

The Roles of CD38 and CD157 in the Solid Tumor Microenvironment and Cancer Immunotherapy
por: Wo, Yu Jun, et al.
Publicado: (2019)

Design and Implementation of NK Cell-Based Immunotherapy to Overcome the Solid Tumor Microenvironment
por: Navin, Ishwar, et al.
Publicado: (2020)

Editorial: Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy
por: Chouaib, Salem, et al.
Publicado: (2020)

Immune modulation of the tumor microenvironment for enhancing cancer immunotherapy
por: Devaud, Christel, et al.
Publicado: (2013)

Tumor immune microenvironment and the current immunotherapy of cholangiocarcinoma (Review)
por: Yang, Siqi, et al.
Publicado: (2023)

Exosomes, Their Biogenesis and Role in Inter-Cellular Communication, Tumor Microenvironment and Cancer Immunotherapy
por: Jella, Kishore Kumar, et al.
Publicado: (2018)

Detection of response to tumor microenvironment–targeted cellular immunotherapy using nano-radiomics
por: Devkota, Laxman, et al.
Publicado: (2020)

Counteracting Immunosuppression in the Tumor Microenvironment by Oncolytic Newcastle Disease Virus and Cellular Immunotherapy
por: Schirrmacher, Volker, et al.
Publicado: (2022)

The Influence of the microbiome on the innate immune microenvironment of solid tumors
por: Charles, Angel, et al.
Publicado: (2023)

The State of Cellular Adoptive Immunotherapy for Neuroblastoma and Other Pediatric Solid Tumors
por: Le, Thanh-Phuong, et al.
Publicado: (2017)

Adoptive cellular immunotherapy for solid neoplasms beyond CAR-T
por: Liu, Qiaofei, et al.
Publicado: (2023)

S79. CAR strategies in solid tumours
por: Rossig, C
Publicado: (2014)

Immune Landscape in Tumor Microenvironment: Implications for Biomarker Development and Immunotherapy
por: Pérez-Romero, Karim, et al.
Publicado: (2020)

Tumor Immune Microenvironments (TIMEs): Responsive Nanoplatforms for Antitumor Immunotherapy
por: Sui, Xueqing, et al.
Publicado: (2020)

Immune Microenvironment Landscape in CNS Tumors and Role in Responses to Immunotherapy
por: Najem, Hinda, et al.
Publicado: (2021)

The role of tumor immune microenvironment in chordoma: promising immunotherapy strategies
por: Xu, Jiuhui, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_amq5nrvejqcl1np7sr82jg3h3i