Differential Sensitivity of the Protein Translation Initiation Machinery and mTOR Signaling to MECP2 Gain- and Loss-of-Function Involves MeCP2 Isoform-Specific Homeostasis in the Brain

Eukaryotic gene expression is controlled at multiple levels, including gene transcription and protein translation initiation. One molecule with key roles in both regulatory mechanisms is methyl CpG binding protein 2 (MeCP2). MECP2 gain- and loss-of-function mutations lead to Rett Syndrome and MECP2...

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Detalles Bibliográficos
Autores principales: Buist, Marjorie, El Tobgy, Nada, Shevkoplyas, Danilo, Genung, Matthew, Sher, Annan Ali, Pejhan, Shervin, Rastegar, Mojgan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105805/
https://www.ncbi.nlm.nih.gov/pubmed/35563748
http://dx.doi.org/10.3390/cells11091442

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