Cargando…

Biomarkers of Response and Resistance to Immunotherapy in Microsatellite Stable Colorectal Cancer: Toward a New Personalized Medicine

SIMPLE SUMMARY: Immune Checkpoint Inhibitors (ICIs) have demonstrated clinical efficacy in Microsatellite Instability High Colorectal Cancer (MSI-H CRC). However, in Microsatellite Stable (MSS) CRC, ICIs monotherapy provides limited clinical benefit. Therefore, efforts must be made to understand the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huyghe, Nicolas, Benidovskaya, Elena, Stevens, Philippe, Van den Eynde, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105843/ https://www.ncbi.nlm.nih.gov/pubmed/35565369 http://dx.doi.org/10.3390/cancers14092241

Ejemplares similares

Immunotherapy with immune checkpoint inhibitors in colorectal cancer: what is the future beyond deficient mismatch-repair tumours?
por: Huyghe, Nicolas, et al.
Publicado: (2019)

Beyond Microsatellite Instability: Evolving Strategies Integrating Immunotherapy for Microsatellite Stable Colorectal Cancer
por: Pecci, Federica, et al.
Publicado: (2021)

Is There a Place for Immunotherapy for Metastatic Microsatellite Stable Colorectal Cancer?
por: Ghiringhelli, François, et al.
Publicado: (2019)

Immunotherapy for Colorectal Cancer with High Microsatellite Instability: The Ongoing Search for Biomarkers
por: Ros, Javier, et al.
Publicado: (2023)

Combination Immunotherapies to Overcome Intrinsic Resistance to Checkpoint Blockade in Microsatellite Stable Colorectal Cancer
por: Kim, Chang Woo, et al.
Publicado: (2021)

The role of immunotherapy in microsatellites stable metastatic colorectal cancer: state of the art and future perspectives
por: Gandini, Annalice, et al.
Publicado: (2023)

Opportunities for immunotherapy in microsatellite instable colorectal cancer
por: Westdorp, Harm, et al.
Publicado: (2016)

The expressed mutational landscape of microsatellite stable colorectal cancers
por: Sveen, Anita, et al.
Publicado: (2021)

Radiation Therapy Enhances Immunotherapy Response in Microsatellite-stable Colorectal and Pancreatic Adenocarcinoma in a Phase II Trial
por: Parikh, Aparna R., et al.
Publicado: (2021)

High microsatellite instability (MSI-H) colorectal carcinoma: a brief review of predictive biomarkers in the era of personalized medicine
por: Gatalica, Zoran, et al.
Publicado: (2016)

SnoN expression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers
por: Chia, June A, et al.
Publicado: (2006)

Blocking IL-17A enhances tumor response to anti-PD-1 immunotherapy in microsatellite stable colorectal cancer
por: Liu, Chao, et al.
Publicado: (2021)

Chromosomal Instability in BRAF Mutant, Microsatellite Stable Colorectal Cancers
por: Bond, Catherine E., et al.
Publicado: (2012)

The Emerging Role of Checkpoint Inhibition in Microsatellite Stable Colorectal Cancer
por: Hermel, David J., et al.
Publicado: (2019)

Advances in immune checkpoint inhibitor combination strategies for microsatellite stable colorectal cancer
por: Ros, Javier, et al.
Publicado: (2023)

Lymphocytic infiltration in stage II microsatellite stable colorectal tumors: A retrospective prognosis biomarker analysis
por: Sanz-Pamplona, Rebeca, et al.
Publicado: (2020)

Extent and location of tumor infiltrating lymphocytes in microsatellite stable colon cancer predict outcome to adjuvant active specific immunotherapy
por: Turksma, Annelies, et al.
Publicado: (2015)

A Comprehensive Biomarker Analysis of Microsatellite Unstable/Mismatch Repair Deficient Colorectal Cancer Cohort Treated with Immunotherapy
por: Élez, Elena, et al.
Publicado: (2022)

Correction: Blocking IL-17A enhances tumor response to anti-PD-1 immunotherapy in microsatellite stable colorectal cancer
Publicado: (2021)

The Gut Microbiome, Microsatellite Status and the Response to Immunotherapy in Colorectal Cancer
por: Sillo, Toritseju O., et al.
Publicado: (2023)

Epigenetic-related gene mutations serve as potential biomarkers for immune checkpoint inhibitors in microsatellite-stable colorectal cancer
por: Liu, Chao, et al.
Publicado: (2022)

Transcriptome and Network Dissection of Microsatellite Stable and Highly Instable Colorectal Cancer
por: Akbari, Vahid, et al.
Publicado: (2019)

Tertiary lymphoid structures in pulmonary metastases of microsatellite stable colorectal cancer
por: Karjula, Topias, et al.
Publicado: (2023)

Chemoimmunotherapy triggers immune responses targeting microsatellite stable colorectal cancer
por: Thibaudin, Marion, et al.
Publicado: (2023)

Editorial: New therapeutic approaches in microsatellite stable colorectal cancer patients
por: Bartolini, Michela, et al.
Publicado: (2023)

Immunotherapy combined with local therapy in the late-line treatment of repair-proficient (pMMR)/microsatellite stable (MSS) metastatic colorectal cancer
por: Ding, Yuwei, et al.
Publicado: (2023)

Colorectal Cancer Biomarkers in the Era of Personalized Medicine
por: Patel, Jai N., et al.
Publicado: (2019)

T cell‐inflamed gene expression profile is associated with favorable disease‐specific survival in non‐hypermutated microsatellite‐stable colorectal cancer patients
por: Yin, Hang, et al.
Publicado: (2022)

The Different Roles of hRAD50 in Microsatellite Stable and Unstable Colorectal Cancers
por: Gao, Jingfang, et al.
Publicado: (2008)

Potentiating effect of reovirus on immune checkpoint inhibition in microsatellite stable colorectal cancer
por: Augustine, Titto, et al.
Publicado: (2022)

Cancer Immunotherapy and Personalized Medicine: Emerging Technologies and Biomarker-Based Approaches
por: Maciejko, Laura, et al.
Publicado: (2017)

Immunotherapy in microsatellite instability metastatic colorectal cancer: Current status and future perspectives
por: Motta, Rodrigo, et al.
Publicado: (2021)

Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups
por: Mansilla, F, et al.
Publicado: (2007)

Alternative splicing expands the prognostic impact of KRAS in microsatellite stable primary colorectal cancer
por: Eilertsen, Ina A., et al.
Publicado: (2018)

Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors
por: Lee, Minyi, et al.
Publicado: (2020)

Molecular drivers of tumor progression in microsatellite stable APC mutation-negative colorectal cancers
por: Grant, Adam, et al.
Publicado: (2021)

ROS1 genomic rearrangements are rare actionable drivers in microsatellite stable colorectal cancer
por: Akhoundova, Dilara, et al.
Publicado: (2022)

Clinical Outcomes of Patients with Recurrent Microsatellite-Stable Endometrial Cancer in Early-Phase Immunotherapy Clinical Trials
por: How, Jeffrey A., et al.
Publicado: (2022)

The role of biomarkers in personalized immunotherapy
por: Sankar, Kamya, et al.
Publicado: (2022)

Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer
por: Hawkins, N J, et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_u58j6cftb31vokasj0cgclhig8