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Efficacy of Colchicine in the Treatment of COVID-19 Patients: A Systematic Review and Meta-Analysis

Objective: We assessed the efficacy of colchicine in COVID-19 patients through a systematic review. Methods: Six databases were searched until March 2022 for studies assessing colchicine versus control in hospitalized patients with COVID-19. The primary outcome was mortality, and secondary outcome w...

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Autores principales: Toro-Huamanchumo, Carlos J., Benites-Meza, Jerry K., Mamani-García, Carlos S., Bustamante-Paytan, Diego, Gracia-Ramos, Abraham Edgar, Diaz-Vélez, Cristian, Barboza, Joshuan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105993/
https://www.ncbi.nlm.nih.gov/pubmed/35566737
http://dx.doi.org/10.3390/jcm11092615
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author Toro-Huamanchumo, Carlos J.
Benites-Meza, Jerry K.
Mamani-García, Carlos S.
Bustamante-Paytan, Diego
Gracia-Ramos, Abraham Edgar
Diaz-Vélez, Cristian
Barboza, Joshuan J.
author_facet Toro-Huamanchumo, Carlos J.
Benites-Meza, Jerry K.
Mamani-García, Carlos S.
Bustamante-Paytan, Diego
Gracia-Ramos, Abraham Edgar
Diaz-Vélez, Cristian
Barboza, Joshuan J.
author_sort Toro-Huamanchumo, Carlos J.
collection PubMed
description Objective: We assessed the efficacy of colchicine in COVID-19 patients through a systematic review. Methods: Six databases were searched until March 2022 for studies assessing colchicine versus control in hospitalized patients with COVID-19. The primary outcome was mortality, and secondary outcome was length of hospitalization. Inverse variance and random effect meta-analyses were performed. The strength of evidence was assessed using GRADE. Results: Nine studies (five randomized clinical trials (RCTs) and four non-randomized studies of intervention (NRSI); n = 13,478). Colchicine did not reduce mortality in comparison with the standard of care in RCTs (RR 0.99; 95%CI 0.90 to 1.10; p = 0.90); however, it did reduce mortality in NRSI studies (RR 0.45; 95%CI 0.26 to 0.77; p = 0.02). In the analysis of RCTs, colchicine did not reduce the length of hospitalization in comparison with the standard of care (MD: −2.25 days; 95%CI: −9.34 to 4.84; p = 0.15). Most studies were scored as having a high risk of bias. Quality of evidence was very low for primary and secondary outcomes. Conclusion: Colchicine did not reduce the mortality and length of hospitalization in comparison with the standard of care in hospitalized patients with COVID-19. The published evidence is insufficient and of very low quality to recommend treatment in patients with COVID-19.
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spelling pubmed-91059932022-05-14 Efficacy of Colchicine in the Treatment of COVID-19 Patients: A Systematic Review and Meta-Analysis Toro-Huamanchumo, Carlos J. Benites-Meza, Jerry K. Mamani-García, Carlos S. Bustamante-Paytan, Diego Gracia-Ramos, Abraham Edgar Diaz-Vélez, Cristian Barboza, Joshuan J. J Clin Med Systematic Review Objective: We assessed the efficacy of colchicine in COVID-19 patients through a systematic review. Methods: Six databases were searched until March 2022 for studies assessing colchicine versus control in hospitalized patients with COVID-19. The primary outcome was mortality, and secondary outcome was length of hospitalization. Inverse variance and random effect meta-analyses were performed. The strength of evidence was assessed using GRADE. Results: Nine studies (five randomized clinical trials (RCTs) and four non-randomized studies of intervention (NRSI); n = 13,478). Colchicine did not reduce mortality in comparison with the standard of care in RCTs (RR 0.99; 95%CI 0.90 to 1.10; p = 0.90); however, it did reduce mortality in NRSI studies (RR 0.45; 95%CI 0.26 to 0.77; p = 0.02). In the analysis of RCTs, colchicine did not reduce the length of hospitalization in comparison with the standard of care (MD: −2.25 days; 95%CI: −9.34 to 4.84; p = 0.15). Most studies were scored as having a high risk of bias. Quality of evidence was very low for primary and secondary outcomes. Conclusion: Colchicine did not reduce the mortality and length of hospitalization in comparison with the standard of care in hospitalized patients with COVID-19. The published evidence is insufficient and of very low quality to recommend treatment in patients with COVID-19. MDPI 2022-05-06 /pmc/articles/PMC9105993/ /pubmed/35566737 http://dx.doi.org/10.3390/jcm11092615 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Toro-Huamanchumo, Carlos J.
Benites-Meza, Jerry K.
Mamani-García, Carlos S.
Bustamante-Paytan, Diego
Gracia-Ramos, Abraham Edgar
Diaz-Vélez, Cristian
Barboza, Joshuan J.
Efficacy of Colchicine in the Treatment of COVID-19 Patients: A Systematic Review and Meta-Analysis
title Efficacy of Colchicine in the Treatment of COVID-19 Patients: A Systematic Review and Meta-Analysis
title_full Efficacy of Colchicine in the Treatment of COVID-19 Patients: A Systematic Review and Meta-Analysis
title_fullStr Efficacy of Colchicine in the Treatment of COVID-19 Patients: A Systematic Review and Meta-Analysis
title_full_unstemmed Efficacy of Colchicine in the Treatment of COVID-19 Patients: A Systematic Review and Meta-Analysis
title_short Efficacy of Colchicine in the Treatment of COVID-19 Patients: A Systematic Review and Meta-Analysis
title_sort efficacy of colchicine in the treatment of covid-19 patients: a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105993/
https://www.ncbi.nlm.nih.gov/pubmed/35566737
http://dx.doi.org/10.3390/jcm11092615
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