Cargando…
Importance of Vaccination against SARS-CoV-2 in Patients with Interstitial Lung Disease Associated with Systemic Autoimmune Disease
Objectives: To describe the frequency of COVID-19 and the effect of vaccination in patients with interstitial lung disease and systemic autoimmune disease (ILD-SAD) and to identify factors associated with infection and severity of COVID-19. Methods: We performed a cross-sectional multicenter study o...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106041/ https://www.ncbi.nlm.nih.gov/pubmed/35566564 http://dx.doi.org/10.3390/jcm11092437 |
_version_ | 1784708186413989888 |
---|---|
author | Mena-Vázquez, Natalia García-Studer, Aimara Rojas-Gimenez, Marta Romero-Barco, Carmen María Manrique-Arija, Sara Mucientes, Arkaitz Velloso-Feijoo, María Luisa Godoy-Navarrete, Francisco Javier Morales-Garrido, Pilar Redondo-Rodríguez, Rocío Ordoñez-Cañizares, MC Ortega-Castro, Rafaela Lisbona-Montañez, Jose Manuel Hidalgo Conde, Ana Arnedo Díez de los Ríos, Rocío Cabrera César, Eva Espildora, Francisco Aguilar-Hurtado, María Carmen Añón-Oñate, Isabel Ureña-Garnica, Inmaculada Fernández-Nebro, Antonio |
author_facet | Mena-Vázquez, Natalia García-Studer, Aimara Rojas-Gimenez, Marta Romero-Barco, Carmen María Manrique-Arija, Sara Mucientes, Arkaitz Velloso-Feijoo, María Luisa Godoy-Navarrete, Francisco Javier Morales-Garrido, Pilar Redondo-Rodríguez, Rocío Ordoñez-Cañizares, MC Ortega-Castro, Rafaela Lisbona-Montañez, Jose Manuel Hidalgo Conde, Ana Arnedo Díez de los Ríos, Rocío Cabrera César, Eva Espildora, Francisco Aguilar-Hurtado, María Carmen Añón-Oñate, Isabel Ureña-Garnica, Inmaculada Fernández-Nebro, Antonio |
author_sort | Mena-Vázquez, Natalia |
collection | PubMed |
description | Objectives: To describe the frequency of COVID-19 and the effect of vaccination in patients with interstitial lung disease and systemic autoimmune disease (ILD-SAD) and to identify factors associated with infection and severity of COVID-19. Methods: We performed a cross-sectional multicenter study of patients with ILD-SAD followed between June and October 2021. The main variable was COVID-19 infection confirmed by a positive polymerase chain reaction (PCR) result for SARS-CoV-2. The secondary variables included severity of COVID-19, if the patient had to be admitted to hospital or died of the disease, and vaccination status. Other variables included clinical and treatment characteristics, pulmonary function and high-resolution computed tomography. Two logistic regression was performed to explore factors associated with “COVID-19” and “severe COVID-19”. Results: We included 176 patients with ILD-SAD: 105 (59.7%) had rheumatoid arthritis, 49 (27.8%) systemic sclerosis, and 22 (12.54%) inflammatory myopathies. We recorded 22/179 (12.5%) SARS-CoV-2 infections, 7/22 (31.8%) of them were severe and 3/22 (13.22%) died. As to the vaccination, 163/176 (92.6%) patients received the complete doses. The factors associated with SARS-CoV-2 infection were FVC (OR (95% CI), 0.971 (0.946–0.989); p = 0.040), vaccination (OR (95% CI), 0.169 (0.030–0.570); p = 0.004), and rituximab (OR (95% CI), 3.490 (1.129–6.100); p = 0.029). The factors associated with severe COVID-19 were the protective effect of the vaccine (OR (95% CI), 0.024 (0.004–0.170); p < 0.001) and diabetes mellitus (OR (95% CI), 4.923 (1.508–19.097); p = 0.018). Conclusions: Around 13% of patients with ILD-SAD had SARS-CoV-2 infection, which was severe in approximately one-third. Most patients with severe infection were not fully vaccinated. |
format | Online Article Text |
id | pubmed-9106041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91060412022-05-14 Importance of Vaccination against SARS-CoV-2 in Patients with Interstitial Lung Disease Associated with Systemic Autoimmune Disease Mena-Vázquez, Natalia García-Studer, Aimara Rojas-Gimenez, Marta Romero-Barco, Carmen María Manrique-Arija, Sara Mucientes, Arkaitz Velloso-Feijoo, María Luisa Godoy-Navarrete, Francisco Javier Morales-Garrido, Pilar Redondo-Rodríguez, Rocío Ordoñez-Cañizares, MC Ortega-Castro, Rafaela Lisbona-Montañez, Jose Manuel Hidalgo Conde, Ana Arnedo Díez de los Ríos, Rocío Cabrera César, Eva Espildora, Francisco Aguilar-Hurtado, María Carmen Añón-Oñate, Isabel Ureña-Garnica, Inmaculada Fernández-Nebro, Antonio J Clin Med Article Objectives: To describe the frequency of COVID-19 and the effect of vaccination in patients with interstitial lung disease and systemic autoimmune disease (ILD-SAD) and to identify factors associated with infection and severity of COVID-19. Methods: We performed a cross-sectional multicenter study of patients with ILD-SAD followed between June and October 2021. The main variable was COVID-19 infection confirmed by a positive polymerase chain reaction (PCR) result for SARS-CoV-2. The secondary variables included severity of COVID-19, if the patient had to be admitted to hospital or died of the disease, and vaccination status. Other variables included clinical and treatment characteristics, pulmonary function and high-resolution computed tomography. Two logistic regression was performed to explore factors associated with “COVID-19” and “severe COVID-19”. Results: We included 176 patients with ILD-SAD: 105 (59.7%) had rheumatoid arthritis, 49 (27.8%) systemic sclerosis, and 22 (12.54%) inflammatory myopathies. We recorded 22/179 (12.5%) SARS-CoV-2 infections, 7/22 (31.8%) of them were severe and 3/22 (13.22%) died. As to the vaccination, 163/176 (92.6%) patients received the complete doses. The factors associated with SARS-CoV-2 infection were FVC (OR (95% CI), 0.971 (0.946–0.989); p = 0.040), vaccination (OR (95% CI), 0.169 (0.030–0.570); p = 0.004), and rituximab (OR (95% CI), 3.490 (1.129–6.100); p = 0.029). The factors associated with severe COVID-19 were the protective effect of the vaccine (OR (95% CI), 0.024 (0.004–0.170); p < 0.001) and diabetes mellitus (OR (95% CI), 4.923 (1.508–19.097); p = 0.018). Conclusions: Around 13% of patients with ILD-SAD had SARS-CoV-2 infection, which was severe in approximately one-third. Most patients with severe infection were not fully vaccinated. MDPI 2022-04-26 /pmc/articles/PMC9106041/ /pubmed/35566564 http://dx.doi.org/10.3390/jcm11092437 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mena-Vázquez, Natalia García-Studer, Aimara Rojas-Gimenez, Marta Romero-Barco, Carmen María Manrique-Arija, Sara Mucientes, Arkaitz Velloso-Feijoo, María Luisa Godoy-Navarrete, Francisco Javier Morales-Garrido, Pilar Redondo-Rodríguez, Rocío Ordoñez-Cañizares, MC Ortega-Castro, Rafaela Lisbona-Montañez, Jose Manuel Hidalgo Conde, Ana Arnedo Díez de los Ríos, Rocío Cabrera César, Eva Espildora, Francisco Aguilar-Hurtado, María Carmen Añón-Oñate, Isabel Ureña-Garnica, Inmaculada Fernández-Nebro, Antonio Importance of Vaccination against SARS-CoV-2 in Patients with Interstitial Lung Disease Associated with Systemic Autoimmune Disease |
title | Importance of Vaccination against SARS-CoV-2 in Patients with Interstitial Lung Disease Associated with Systemic Autoimmune Disease |
title_full | Importance of Vaccination against SARS-CoV-2 in Patients with Interstitial Lung Disease Associated with Systemic Autoimmune Disease |
title_fullStr | Importance of Vaccination against SARS-CoV-2 in Patients with Interstitial Lung Disease Associated with Systemic Autoimmune Disease |
title_full_unstemmed | Importance of Vaccination against SARS-CoV-2 in Patients with Interstitial Lung Disease Associated with Systemic Autoimmune Disease |
title_short | Importance of Vaccination against SARS-CoV-2 in Patients with Interstitial Lung Disease Associated with Systemic Autoimmune Disease |
title_sort | importance of vaccination against sars-cov-2 in patients with interstitial lung disease associated with systemic autoimmune disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106041/ https://www.ncbi.nlm.nih.gov/pubmed/35566564 http://dx.doi.org/10.3390/jcm11092437 |
work_keys_str_mv | AT menavazqueznatalia importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT garciastuderaimara importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT rojasgimenezmarta importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT romerobarcocarmenmaria importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT manriquearijasara importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT mucientesarkaitz importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT vellosofeijoomarialuisa importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT godoynavarretefranciscojavier importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT moralesgarridopilar importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT redondorodriguezrocio importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT ordonezcanizaresmc importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT ortegacastrorafaela importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT lisbonamontanezjosemanuel importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT hidalgocondeana importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT arnedodiezdelosriosrocio importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT cabreracesareva importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT espildorafrancisco importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT aguilarhurtadomariacarmen importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT anononateisabel importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT urenagarnicainmaculada importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease AT fernandeznebroantonio importanceofvaccinationagainstsarscov2inpatientswithinterstitiallungdiseaseassociatedwithsystemicautoimmunedisease |