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Persistent cryoglobulinemia after antiviral treatment is associated with advanced fibrosis in chronic hepatitis C patients
BACKGROUND: High dosage and longer duration of antiviral treatment has been suggested to treat cryoglobulinemia patients. We aimed to investigate the efficacy of antiviral treatment in cryoglobulinemia patients and analyze the associated factors of persistent cryoglobulinemia. METHODS: Totally 148 p...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106159/ https://www.ncbi.nlm.nih.gov/pubmed/35560166 http://dx.doi.org/10.1371/journal.pone.0268180 |
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author | Batsaikhan, Batbold Huang, Ching-I. Yeh, Ming-Lun Huang, Chung-Feng Lin, Yi-Hung Liang, Po-Cheng Hsieh, Ming-Yen Lin, Yi-Ching Huang, Jee-Fu Chuang, Wan-Long Lee, Jin-Ching Yu, Ming-Lung Kuo, Hsing-Tao Dai, Chia-Yen |
author_facet | Batsaikhan, Batbold Huang, Ching-I. Yeh, Ming-Lun Huang, Chung-Feng Lin, Yi-Hung Liang, Po-Cheng Hsieh, Ming-Yen Lin, Yi-Ching Huang, Jee-Fu Chuang, Wan-Long Lee, Jin-Ching Yu, Ming-Lung Kuo, Hsing-Tao Dai, Chia-Yen |
author_sort | Batsaikhan, Batbold |
collection | PubMed |
description | BACKGROUND: High dosage and longer duration of antiviral treatment has been suggested to treat cryoglobulinemia patients. We aimed to investigate the efficacy of antiviral treatment in cryoglobulinemia patients and analyze the associated factors of persistent cryoglobulinemia. METHODS: Totally 148 patients after completion of anti-HCV treatment were enrolled in our study. Serum cryoglobulinemia precipitation was assessed and analyzed for the associated factors after antiviral therapy. RESULTS: Fifty-one (34.5%) out of 148 patients were positive for serum cryoglobulinemia after completion of antiviral therapy. In multivariate analysis, advanced fibrosis (Odds Ratio [OR]– 4.13, 95% Confidence Interval [95% CI]– 1.53–11.17, p = 0.005) and platelet counts (OR-0.98, 95% CI– 0.97–0.99, p = 0.010) were independently and significantly associated with persistent cryoglobulinemia. The factors associated with the persistent cryoglobulinemia in SVR patients were advanced fibrosis (OR-1.93, 95% CI– 1.02–3.65, p = 0.041) and platelet count (OR-0.98, 95% CI– 0.96–0.99, p = 0.041) by multivariate analysis. Multivariate logistic regression analysis showed persistent (OR-4.83, 95% CI– 1.75–13.36, p = 0.002) was significantly associated with advanced fibrosis in patients with cryoglobulinemia follow up after antiviral therapy. CONCLUSIONS: The prevalence of the persistent cryoglobulinemia is 34.5% after completing antiviral therapy and it is associated with advanced fibrosis, also HCV clearance. |
format | Online Article Text |
id | pubmed-9106159 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-91061592022-05-14 Persistent cryoglobulinemia after antiviral treatment is associated with advanced fibrosis in chronic hepatitis C patients Batsaikhan, Batbold Huang, Ching-I. Yeh, Ming-Lun Huang, Chung-Feng Lin, Yi-Hung Liang, Po-Cheng Hsieh, Ming-Yen Lin, Yi-Ching Huang, Jee-Fu Chuang, Wan-Long Lee, Jin-Ching Yu, Ming-Lung Kuo, Hsing-Tao Dai, Chia-Yen PLoS One Research Article BACKGROUND: High dosage and longer duration of antiviral treatment has been suggested to treat cryoglobulinemia patients. We aimed to investigate the efficacy of antiviral treatment in cryoglobulinemia patients and analyze the associated factors of persistent cryoglobulinemia. METHODS: Totally 148 patients after completion of anti-HCV treatment were enrolled in our study. Serum cryoglobulinemia precipitation was assessed and analyzed for the associated factors after antiviral therapy. RESULTS: Fifty-one (34.5%) out of 148 patients were positive for serum cryoglobulinemia after completion of antiviral therapy. In multivariate analysis, advanced fibrosis (Odds Ratio [OR]– 4.13, 95% Confidence Interval [95% CI]– 1.53–11.17, p = 0.005) and platelet counts (OR-0.98, 95% CI– 0.97–0.99, p = 0.010) were independently and significantly associated with persistent cryoglobulinemia. The factors associated with the persistent cryoglobulinemia in SVR patients were advanced fibrosis (OR-1.93, 95% CI– 1.02–3.65, p = 0.041) and platelet count (OR-0.98, 95% CI– 0.96–0.99, p = 0.041) by multivariate analysis. Multivariate logistic regression analysis showed persistent (OR-4.83, 95% CI– 1.75–13.36, p = 0.002) was significantly associated with advanced fibrosis in patients with cryoglobulinemia follow up after antiviral therapy. CONCLUSIONS: The prevalence of the persistent cryoglobulinemia is 34.5% after completing antiviral therapy and it is associated with advanced fibrosis, also HCV clearance. Public Library of Science 2022-05-13 /pmc/articles/PMC9106159/ /pubmed/35560166 http://dx.doi.org/10.1371/journal.pone.0268180 Text en © 2022 Batsaikhan et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Batsaikhan, Batbold Huang, Ching-I. Yeh, Ming-Lun Huang, Chung-Feng Lin, Yi-Hung Liang, Po-Cheng Hsieh, Ming-Yen Lin, Yi-Ching Huang, Jee-Fu Chuang, Wan-Long Lee, Jin-Ching Yu, Ming-Lung Kuo, Hsing-Tao Dai, Chia-Yen Persistent cryoglobulinemia after antiviral treatment is associated with advanced fibrosis in chronic hepatitis C patients |
title | Persistent cryoglobulinemia after antiviral treatment is associated with advanced fibrosis in chronic hepatitis C patients |
title_full | Persistent cryoglobulinemia after antiviral treatment is associated with advanced fibrosis in chronic hepatitis C patients |
title_fullStr | Persistent cryoglobulinemia after antiviral treatment is associated with advanced fibrosis in chronic hepatitis C patients |
title_full_unstemmed | Persistent cryoglobulinemia after antiviral treatment is associated with advanced fibrosis in chronic hepatitis C patients |
title_short | Persistent cryoglobulinemia after antiviral treatment is associated with advanced fibrosis in chronic hepatitis C patients |
title_sort | persistent cryoglobulinemia after antiviral treatment is associated with advanced fibrosis in chronic hepatitis c patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106159/ https://www.ncbi.nlm.nih.gov/pubmed/35560166 http://dx.doi.org/10.1371/journal.pone.0268180 |
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