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Perspective of nuclear fractal dimension in diagnosis and prognosis of oral squamous cell carcinoma
BACKGROUND: Owing to the restricted predictive value of conventional prognostic factors and the inconsistent treatment strategies, several oral squamous cell carcinoma (OSCC) patients are still over-treated or under-treated. In recent years, computer-assisted nuclear fractal dimension (nFD) has emer...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106250/ https://www.ncbi.nlm.nih.gov/pubmed/35571291 http://dx.doi.org/10.4103/jomfp.jomfp_470_20 |
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author | Rahman, Juber Panda, Swagatika Panigrahi, Santisudha Mohanty, Neeta Swarnkar, Tripti Mishra, Umashankar |
author_facet | Rahman, Juber Panda, Swagatika Panigrahi, Santisudha Mohanty, Neeta Swarnkar, Tripti Mishra, Umashankar |
author_sort | Rahman, Juber |
collection | PubMed |
description | BACKGROUND: Owing to the restricted predictive value of conventional prognostic factors and the inconsistent treatment strategies, several oral squamous cell carcinoma (OSCC) patients are still over-treated or under-treated. In recent years, computer-assisted nuclear fractal dimension (nFD) has emerged as an objective approach to predict the outcome of OSCC. OBJECTIVE: This study is an attempt to find out the differences in nFD values of epithelial cells of normal tissue, fibroepithelial hyperplasia, verrucous carcinoma, and OSCC. Further effort to evaluate the predictive potential of nFD of tumor cells for cervical lymph node metastasis (cLNM) was also assessed. METHODOLOGY: Formalin-fixed paraffin-embedded blocks of OSCC tissues of patients treated with neck dissection were collected. Photomicrographs of H-&E-stained sections were subjected to the image analysis by ImageJ and Python programming to calculate nFD. The association of categorical variables with nFD was studied using cross-tabulation procedure and the Fisher exact test. Receiver operating curve analysis was performed to find out cutoff value of nFD. A logistic regression model was developed to test the individual and combined predictive potential of grading and nFD for cLNM. RESULTS: A significant difference between the mean nFD of healthy cells and malignant epithelial cells was observed (P = 0.01). nFD was not found to be an independent predictor of cLNM, although nFD and grading together demonstrated significant predictive potential (P = 0.004). CONCLUSION: nFD combined with grading can predict lymph node metastasis in OSCC. To the best of our knowledge, this is the first study of its kind. |
format | Online Article Text |
id | pubmed-9106250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-91062502022-05-14 Perspective of nuclear fractal dimension in diagnosis and prognosis of oral squamous cell carcinoma Rahman, Juber Panda, Swagatika Panigrahi, Santisudha Mohanty, Neeta Swarnkar, Tripti Mishra, Umashankar J Oral Maxillofac Pathol Original Article BACKGROUND: Owing to the restricted predictive value of conventional prognostic factors and the inconsistent treatment strategies, several oral squamous cell carcinoma (OSCC) patients are still over-treated or under-treated. In recent years, computer-assisted nuclear fractal dimension (nFD) has emerged as an objective approach to predict the outcome of OSCC. OBJECTIVE: This study is an attempt to find out the differences in nFD values of epithelial cells of normal tissue, fibroepithelial hyperplasia, verrucous carcinoma, and OSCC. Further effort to evaluate the predictive potential of nFD of tumor cells for cervical lymph node metastasis (cLNM) was also assessed. METHODOLOGY: Formalin-fixed paraffin-embedded blocks of OSCC tissues of patients treated with neck dissection were collected. Photomicrographs of H-&E-stained sections were subjected to the image analysis by ImageJ and Python programming to calculate nFD. The association of categorical variables with nFD was studied using cross-tabulation procedure and the Fisher exact test. Receiver operating curve analysis was performed to find out cutoff value of nFD. A logistic regression model was developed to test the individual and combined predictive potential of grading and nFD for cLNM. RESULTS: A significant difference between the mean nFD of healthy cells and malignant epithelial cells was observed (P = 0.01). nFD was not found to be an independent predictor of cLNM, although nFD and grading together demonstrated significant predictive potential (P = 0.004). CONCLUSION: nFD combined with grading can predict lymph node metastasis in OSCC. To the best of our knowledge, this is the first study of its kind. Wolters Kluwer - Medknow 2022 2022-03-31 /pmc/articles/PMC9106250/ /pubmed/35571291 http://dx.doi.org/10.4103/jomfp.jomfp_470_20 Text en Copyright: © 2022 Journal of Oral and Maxillofacial Pathology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Rahman, Juber Panda, Swagatika Panigrahi, Santisudha Mohanty, Neeta Swarnkar, Tripti Mishra, Umashankar Perspective of nuclear fractal dimension in diagnosis and prognosis of oral squamous cell carcinoma |
title | Perspective of nuclear fractal dimension in diagnosis and prognosis of oral squamous cell carcinoma |
title_full | Perspective of nuclear fractal dimension in diagnosis and prognosis of oral squamous cell carcinoma |
title_fullStr | Perspective of nuclear fractal dimension in diagnosis and prognosis of oral squamous cell carcinoma |
title_full_unstemmed | Perspective of nuclear fractal dimension in diagnosis and prognosis of oral squamous cell carcinoma |
title_short | Perspective of nuclear fractal dimension in diagnosis and prognosis of oral squamous cell carcinoma |
title_sort | perspective of nuclear fractal dimension in diagnosis and prognosis of oral squamous cell carcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106250/ https://www.ncbi.nlm.nih.gov/pubmed/35571291 http://dx.doi.org/10.4103/jomfp.jomfp_470_20 |
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