Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation

Inflammasomes sense intrinsic and extrinsic danger signals to trigger inflammatory responses and pyroptotic cell death. Homotypic pyrin domain (PYD) interactions of inflammasome forming nucleotide-binding oligomerization domain (NOD)–like receptors with the adaptor protein ASC (apoptosis-associated...

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Detalles Bibliográficos
Autores principales: Hochheiser, Inga V., Behrmann, Heide, Hagelueken, Gregor, Rodríguez-Alcázar, Juan F., Kopp, Anja, Latz, Eicke, Behrmann, Elmar, Geyer, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106292/
https://www.ncbi.nlm.nih.gov/pubmed/35559676
http://dx.doi.org/10.1126/sciadv.abn7583

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