Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer

In small cell lung cancer (SCLC), acquired resistance to DNA-damaging therapy is challenging to study because rebiopsy is rarely performed. We used patient-derived xenograft models, established before therapy and after progression, to dissect acquired resistance to olaparib plus temozolomide (OT), a...

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Detalles Bibliográficos
Autores principales: Stanzione, Marcello, Zhong, Jun, Wong, Edmond, LaSalle, Thomas J., Wise, Jillian F., Simoneau, Antoine, Myers, David T., Phat, Sarah, Sade-Feldman, Moshe, Lawrence, Michael S., Hadden, M. Kyle, Zou, Lee, Farago, Anna F., Dyson, Nicholas J., Drapkin, Benjamin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106301/
https://www.ncbi.nlm.nih.gov/pubmed/35559669
http://dx.doi.org/10.1126/sciadv.abn1229

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