A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells

To identify roles of RNA binding proteins (RBPs) in the differentiation or survival of antibody secreting plasma cells we performed a CRISPR/Cas9 knockout screen of 1213 mouse RBPs for their ability to affect proliferation and/or survival, and the abundance of differentiated CD138 + cells in vitro....

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Detalles Bibliográficos
Autores principales: Turner, David J, Saveliev, Alexander, Salerno, Fiamma, Matheson, Louise S, Screen, Michael, Lawson, Hannah, Wotherspoon, David, Kranc, Kamil R, Turner, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106329/
https://www.ncbi.nlm.nih.gov/pubmed/35451955
http://dx.doi.org/10.7554/eLife.72313

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