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Efficient differentiation of human primordial germ cells through geometric control reveals a key role for Nodal signaling

Human primordial germ cells (hPGCs) form around the time of implantation and are the precursors of eggs and sperm. Many aspects of hPGC specification remain poorly understood because of the inaccessibility of the early postimplantation human embryo for study. Here, we show that micropatterned human...

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Detalles Bibliográficos
Autores principales:	Jo, Kyoung, Teague, Seth, Chen, Bohan, Khan, Hina Aftab, Freeburne, Emily, Li, Hunter, Li, Bolin, Ran, Ran, Spence, Jason R, Heemskerk, Idse
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106331/ https://www.ncbi.nlm.nih.gov/pubmed/35394424 http://dx.doi.org/10.7554/eLife.72811

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