HDAC6 modulates myofibril stiffness and diastolic function of the heart

Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD), while augmented titin compliance appears to impair systolic performance...

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Detalles Bibliográficos
Autores principales: Lin, Ying-Hsi, Major, Jennifer L., Liebner, Tim, Hourani, Zaynab, Travers, Joshua G., Wennersten, Sara A., Haefner, Korey R., Cavasin, Maria A., Wilson, Cortney E., Jeong, Mark Y., Han, Yu, Gotthardt, Michael, Ferguson, Scott K., Ambardekar, Amrut V., Lam, Maggie P.Y., Choudhary, Chunaram, Granzier, Henk L., Woulfe, Kathleen C., McKinsey, Timothy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106344/
https://www.ncbi.nlm.nih.gov/pubmed/35575093
http://dx.doi.org/10.1172/JCI148333

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