Iron deficiency linked to altered bile acid metabolism promotes Helicobacter pylori–induced inflammation–driven gastric carcinogenesis

Gastric carcinogenesis is mediated by complex interactions among Helicobacter pylori, host, and environmental factors. Here, we demonstrate that H. pylori augmented gastric injury in INS-GAS mice under iron-deficient conditions. Mechanistically, these phenotypes were not driven by alterations in the...

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Detalles Bibliográficos
Autores principales: Noto, Jennifer M., Piazuelo, M. Blanca, Shah, Shailja C., Romero-Gallo, Judith, Hart, Jessica L., Di, Chao, Carmichael, James D., Delgado, Alberto G., Halvorson, Alese E., Greevy, Robert A., Wroblewski, Lydia E., Sharma, Ayushi, Newton, Annabelle B., Allaman, Margaret M., Wilson, Keith T., Washington, M. Kay, Calcutt, M. Wade, Schey, Kevin L., Cummings, Bethany P., Flynn, Charles R., Zackular, Joseph P., Peek, Richard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106351/
https://www.ncbi.nlm.nih.gov/pubmed/35316215
http://dx.doi.org/10.1172/JCI147822

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