Cargando…
Neuroinflammatory Disease following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children
OBJECTIVE: To describe neurologic, radiologic and laboratory features in children with central nervous system (CNS) inflammatory disease complicating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. STUDY DESIGN: We focused on CNS inflammatory diseases in children referred fro...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106400/ https://www.ncbi.nlm.nih.gov/pubmed/35577119 http://dx.doi.org/10.1016/j.jpeds.2022.05.018 |
_version_ | 1784708275239911424 |
---|---|
author | Aubart, Melodie Roux, Charles-Joris Durrleman, Chloé Gins, Clarisse Hully, Marie Kossorotoff, Manoelle Gitiaux, Cyril Levy, Raphaël Moulin, Florence Debray, Agathe Belhadjer, Zahra Georget, Emilie Kom, Temi Blanc, Philippe Wehbi, Samer Mazeghrane, Mustapha Tencer, Jeremie Gajdos, Vincent Rouget, Sebastien De Pontual, Loic Basmaci, Romain Yacouben, Karima Angoulvant, Francois Leruez-Ville, Marianne Sterlin, Delphine Rozenberg, Flore Robert, Matthieu P. Zhang, Shen-Ying Boddaert, Nathalie Desguerre, Isabelle |
author_facet | Aubart, Melodie Roux, Charles-Joris Durrleman, Chloé Gins, Clarisse Hully, Marie Kossorotoff, Manoelle Gitiaux, Cyril Levy, Raphaël Moulin, Florence Debray, Agathe Belhadjer, Zahra Georget, Emilie Kom, Temi Blanc, Philippe Wehbi, Samer Mazeghrane, Mustapha Tencer, Jeremie Gajdos, Vincent Rouget, Sebastien De Pontual, Loic Basmaci, Romain Yacouben, Karima Angoulvant, Francois Leruez-Ville, Marianne Sterlin, Delphine Rozenberg, Flore Robert, Matthieu P. Zhang, Shen-Ying Boddaert, Nathalie Desguerre, Isabelle |
author_sort | Aubart, Melodie |
collection | PubMed |
description | OBJECTIVE: To describe neurologic, radiologic and laboratory features in children with central nervous system (CNS) inflammatory disease complicating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. STUDY DESIGN: We focused on CNS inflammatory diseases in children referred from 12 hospitals in the Paris area to Necker-Sick Children Reference Centre. RESULTS: We identified 19 children who had a history of SARS-CoV-2 infection and manifest a variety of CNS inflammatory diseases: encephalopathy, cerebellar ataxia, acute disseminated encephalomyelitis, neuromyelitis optica spectrum disorder, or optic neuritis. All patients had a history of SARS-CoV-2 exposure, and all tested positive for circulating antibodies against SARS-CoV-2. At the onset of the neurologic disease, SARS-CoV-2 PCR results (nasopharyngeal swabs) were positive in 8 children. Cerebrospinal fluid was abnormal in 58% (11/19) and magnetic resonance imaging was abnormal in 74% (14/19). We identified an autoantibody co-trigger in 4 children (myelin-oligodendrocyte and aquaporin 4 antibodies), representing 21% of the cases. No autoantibody was found in the 6 children whose CNS inflammation was accompanied by a multisystem inflammatory syndrome in children. Overall, 89% of patients (17/19) received anti-inflammatory treatment, primarily high-pulse methylprednisolone. All patients had a complete long-term recovery and, to date, no patient with autoantibodies presented with a relapse. CONCLUSIONS: SARS2-CoV-2 represents a new trigger of postinfectious CNS inflammatory diseases in children. |
format | Online Article Text |
id | pubmed-9106400 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91064002022-05-16 Neuroinflammatory Disease following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children Aubart, Melodie Roux, Charles-Joris Durrleman, Chloé Gins, Clarisse Hully, Marie Kossorotoff, Manoelle Gitiaux, Cyril Levy, Raphaël Moulin, Florence Debray, Agathe Belhadjer, Zahra Georget, Emilie Kom, Temi Blanc, Philippe Wehbi, Samer Mazeghrane, Mustapha Tencer, Jeremie Gajdos, Vincent Rouget, Sebastien De Pontual, Loic Basmaci, Romain Yacouben, Karima Angoulvant, Francois Leruez-Ville, Marianne Sterlin, Delphine Rozenberg, Flore Robert, Matthieu P. Zhang, Shen-Ying Boddaert, Nathalie Desguerre, Isabelle J Pediatr Original Article OBJECTIVE: To describe neurologic, radiologic and laboratory features in children with central nervous system (CNS) inflammatory disease complicating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. STUDY DESIGN: We focused on CNS inflammatory diseases in children referred from 12 hospitals in the Paris area to Necker-Sick Children Reference Centre. RESULTS: We identified 19 children who had a history of SARS-CoV-2 infection and manifest a variety of CNS inflammatory diseases: encephalopathy, cerebellar ataxia, acute disseminated encephalomyelitis, neuromyelitis optica spectrum disorder, or optic neuritis. All patients had a history of SARS-CoV-2 exposure, and all tested positive for circulating antibodies against SARS-CoV-2. At the onset of the neurologic disease, SARS-CoV-2 PCR results (nasopharyngeal swabs) were positive in 8 children. Cerebrospinal fluid was abnormal in 58% (11/19) and magnetic resonance imaging was abnormal in 74% (14/19). We identified an autoantibody co-trigger in 4 children (myelin-oligodendrocyte and aquaporin 4 antibodies), representing 21% of the cases. No autoantibody was found in the 6 children whose CNS inflammation was accompanied by a multisystem inflammatory syndrome in children. Overall, 89% of patients (17/19) received anti-inflammatory treatment, primarily high-pulse methylprednisolone. All patients had a complete long-term recovery and, to date, no patient with autoantibodies presented with a relapse. CONCLUSIONS: SARS2-CoV-2 represents a new trigger of postinfectious CNS inflammatory diseases in children. Elsevier Inc. 2022-08 2022-05-14 /pmc/articles/PMC9106400/ /pubmed/35577119 http://dx.doi.org/10.1016/j.jpeds.2022.05.018 Text en © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Article Aubart, Melodie Roux, Charles-Joris Durrleman, Chloé Gins, Clarisse Hully, Marie Kossorotoff, Manoelle Gitiaux, Cyril Levy, Raphaël Moulin, Florence Debray, Agathe Belhadjer, Zahra Georget, Emilie Kom, Temi Blanc, Philippe Wehbi, Samer Mazeghrane, Mustapha Tencer, Jeremie Gajdos, Vincent Rouget, Sebastien De Pontual, Loic Basmaci, Romain Yacouben, Karima Angoulvant, Francois Leruez-Ville, Marianne Sterlin, Delphine Rozenberg, Flore Robert, Matthieu P. Zhang, Shen-Ying Boddaert, Nathalie Desguerre, Isabelle Neuroinflammatory Disease following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children |
title | Neuroinflammatory Disease following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children |
title_full | Neuroinflammatory Disease following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children |
title_fullStr | Neuroinflammatory Disease following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children |
title_full_unstemmed | Neuroinflammatory Disease following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children |
title_short | Neuroinflammatory Disease following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children |
title_sort | neuroinflammatory disease following severe acute respiratory syndrome coronavirus 2 infection in children |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106400/ https://www.ncbi.nlm.nih.gov/pubmed/35577119 http://dx.doi.org/10.1016/j.jpeds.2022.05.018 |
work_keys_str_mv | AT aubartmelodie neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT rouxcharlesjoris neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT durrlemanchloe neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT ginsclarisse neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT hullymarie neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT kossorotoffmanoelle neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT gitiauxcyril neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT levyraphael neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT moulinflorence neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT debrayagathe neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT belhadjerzahra neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT georgetemilie neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT komtemi neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT blancphilippe neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT wehbisamer neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT mazeghranemustapha neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT tencerjeremie neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT gajdosvincent neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT rougetsebastien neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT depontualloic neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT basmaciromain neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT yacoubenkarima neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT angoulvantfrancois neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT leruezvillemarianne neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT sterlindelphine neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT rozenbergflore neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT robertmatthieup neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT zhangshenying neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT boddaertnathalie neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren AT desguerreisabelle neuroinflammatorydiseasefollowingsevereacuterespiratorysyndromecoronavirus2infectioninchildren |