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The Role of Mitochondrial Dynamin in Stroke
Stroke is one of the leading causes of death and disability in the world. However, the pathophysiological process of stroke is still not fully clarified. Mitochondria play an important role in promoting nerve survival and are an important drug target for the treatment of stroke. Mitochondrial dysfun...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106451/ https://www.ncbi.nlm.nih.gov/pubmed/35571256 http://dx.doi.org/10.1155/2022/2504798 |
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author | Li, Chenchen Chen, Chunli Qin, Haiyun Ao, Chuncao Chen, Jinlun Tan, Jieqiong Zeng, Liuwang |
author_facet | Li, Chenchen Chen, Chunli Qin, Haiyun Ao, Chuncao Chen, Jinlun Tan, Jieqiong Zeng, Liuwang |
author_sort | Li, Chenchen |
collection | PubMed |
description | Stroke is one of the leading causes of death and disability in the world. However, the pathophysiological process of stroke is still not fully clarified. Mitochondria play an important role in promoting nerve survival and are an important drug target for the treatment of stroke. Mitochondrial dysfunction is one of the hallmarks of stroke. Mitochondria are in a state of continuous fission and fusion, which are termed as mitochondrial dynamics. Mitochondrial dynamics are very important for maintaining various functions of mitochondria. In this review, we will introduce the structure and functions of mitochondrial fission and fusion related proteins and discuss their role in the pathophysiologic process of stroke. A better understanding of mitochondrial dynamin in stroke will pave way for the development of new therapeutic options. |
format | Online Article Text |
id | pubmed-9106451 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-91064512022-05-14 The Role of Mitochondrial Dynamin in Stroke Li, Chenchen Chen, Chunli Qin, Haiyun Ao, Chuncao Chen, Jinlun Tan, Jieqiong Zeng, Liuwang Oxid Med Cell Longev Review Article Stroke is one of the leading causes of death and disability in the world. However, the pathophysiological process of stroke is still not fully clarified. Mitochondria play an important role in promoting nerve survival and are an important drug target for the treatment of stroke. Mitochondrial dysfunction is one of the hallmarks of stroke. Mitochondria are in a state of continuous fission and fusion, which are termed as mitochondrial dynamics. Mitochondrial dynamics are very important for maintaining various functions of mitochondria. In this review, we will introduce the structure and functions of mitochondrial fission and fusion related proteins and discuss their role in the pathophysiologic process of stroke. A better understanding of mitochondrial dynamin in stroke will pave way for the development of new therapeutic options. Hindawi 2022-05-06 /pmc/articles/PMC9106451/ /pubmed/35571256 http://dx.doi.org/10.1155/2022/2504798 Text en Copyright © 2022 Chenchen Li et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Li, Chenchen Chen, Chunli Qin, Haiyun Ao, Chuncao Chen, Jinlun Tan, Jieqiong Zeng, Liuwang The Role of Mitochondrial Dynamin in Stroke |
title | The Role of Mitochondrial Dynamin in Stroke |
title_full | The Role of Mitochondrial Dynamin in Stroke |
title_fullStr | The Role of Mitochondrial Dynamin in Stroke |
title_full_unstemmed | The Role of Mitochondrial Dynamin in Stroke |
title_short | The Role of Mitochondrial Dynamin in Stroke |
title_sort | role of mitochondrial dynamin in stroke |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106451/ https://www.ncbi.nlm.nih.gov/pubmed/35571256 http://dx.doi.org/10.1155/2022/2504798 |
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